Prof. Dr. Matthias Schlesner
| Telefon: | (+49) 0821 - 598 - 5915 |
| E-Mail: | matthias.schlesner@uni-auni-a.de () |
| Raum: | 9011 (BCM) |
| Sprechzeiten: | nach Vereinbarung |
| Adresse: | Alter Postweg 101 (Büro Center Messe), 86159 Augsburg |
AKADEMISCHER WERDEGANG
- Seit 2020: Ordinarius, Lehrstuhlinhaber: Biomedizinische Informatik, Data Mining und Data Analytics, Fakult?t für Angewandte Informatik, Universit?t Augsburg
- 2017-2020: Leiter der Nachwuchsgruppe Bioinformatik und Omics Datenanalyse, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg
- 2013-2017: Gruppenleiter Computational Oncology in der Abteilung Theoretische Bioinformatik, DKFZ
- 2011-2013:?Postdoc: Abteilung Theoretische Bioinformatik, DKFZ
- 2009-2011: Postdoc: Forschungsgruppe für Membranbiochemie, Max-Planck-Institut für Biochemie, Martinsried
- 2008: Promotion (Dr. rer. nat.): Biochemie,?Ludwig-Maximilians-Universit?t München, Titel: “The Halobacterium salinarum Taxis Signal Transduction Network: a Protein-Protein Interaction Study“
- 2004-2008: Doktorand: Biochemie, Ludwig-Maximilians-Universit?t München
- 1998-2003: Diplom: Humanbiologie,?Philipps-Universit?t Marburg
Research Impact
MITGLIEDSCHAFTEN
- Seit 2017:?GMDS (Deutsche Gesellschaft für 伟德国际_伟德国际1946$娱乐app游戏izinische Informatik, Biometrie und Epidemiologie)
- 2019-2020: Mitglied des Lenkungsausschusses der Helmholtz Information & Data Science School for Health
- 2018-2020: Principal Investgator der Helmholtz Information & Data Science School for Health
- 2017-2020: Fakult?tsmitglied des Bachelorstudiengangs ?Major Cancer Biology” am Deutschen Krebsforschungszentrum (DKFZ)
- 2017-2020:?Principal Investigator am Deutschen Zentrum für Lungenforschung (DZL)
LEHRVERANSTALTUNGEN
SOMMERSEMESTER 2024
- Bioinformatik 2 (Vorlesung)
- Bioinformatische Analysen (Vorlesung)
- Current Topics in 伟德国际_伟德国际1946$娱乐app游戏ical Information Sciences (Kolloquium)
- Biomedizinische Informatik (MA-Seminar)
- Biomedizinische Informatik (Oberseminar)
WINTERSEMESTER 2023/24
- Bioinformatik 1 (Vorlesung)
- Bioinformatische Analysen (Vorlesung)
- Current Topics in 伟德国际_伟德国际1946$娱乐app游戏ical Information Sciences (Kolloquium)
- 伟德国际_伟德国际1946$娱乐app游戏izinisches und Naturwissenschaftliches Grundlagenseminar (Vorlesung)
- Biomedizinische Informatik (MA-Seminar)
- Biomedizinische Informatik (Oberseminar)
SOMMERSEMESTER 2023
- Bioinformatik 2 (Vorlesung)
- Current Topics in 伟德国际_伟德国际1946$娱乐app游戏ical Information Sciences (Kolloquium)
- Biomedizinische Informatik (MA-Praktikum)
- Biomedizinische Informatik (MA-Seminar)
- Biomedizinische Informatik (Oberseminar)
WINTERSEMESTER 2022/23
- Bioinformatik 1 (Vorlesung)
- Bioinformatische Analysen (Vorlesung)
- 伟德国际_伟德国际1946$娱乐app游戏izinisches und Naturwissenschaftliches Grundlagenseminar (Vorlesung)
- Biomedizinische Informatik (MA-Praktikum)
- Biomedizinische Informatik (BA-Seminar)
- Biomedizinische Informatik (MA-Seminar)
- Biomedizinische Informatik (Oberseminar)
SOMMERSEMESTER 2022
- Bioinformatik 2 (Vorlesung)
- Grundlagen der biomedizinischen Informatik (Vorlesung)
- Biomedizinische Informatik (MA-Praktikum)
- Biomedizinische Informatik (BA-Seminar)
- Biomedizinische Informatik (MA-Seminar)
- Biomedizinische Informatik (Oberseminar)
WINTERSEMESTER 2021/22
- Bioinformatik 1 (Vorlesung)
- Bioinformatische Analysen (Vorlesung)
- 伟德国际_伟德国际1946$娱乐app游戏izinisches und Naturwissenschaftliches Grundlagenseminar (Vorlesung)
- Biomedizinische Informatik (BA-Seminar)
- Biomedizinische Informatik (MA-Seminar)
- Biomedizinische Informatik (Oberseminar)
SOMMERSEMESTER 2021
- Grundlagen der biomedizinischen Informatik (Vorlesung)
- Biomedizinische Informatik (BA-Seminar)
- Biomedizinische Informatik (Oberseminar)
WINTERSEMESTER 2020/21
- Grundlagen der biomedizinischen Informatik (Vorlesung)
- 伟德国际_伟德国际1946$娱乐app游戏izinisches und naturwissenschaftliches Grundlagenseminar (Seminar)
- Biomedizinische Informatik (BA-Seminar)
- Biomedizinische Informatik (Oberseminar)
REVIEWER
Reviewer für bioinformatische und biomedizinische Fachzeitschriften wie Bioinformatics, BMC Bioinformatics, BMC Genomics, International Journal of Cancer, Journal of Molecular 伟德国际_伟德国际1946$娱乐app游戏icine, Leukemia, Molecular Oncology, Nature Communications, Nature 伟德国际_伟德国际1946$娱乐app游戏icine, PLoS Computational Biology, PLoS Genetics, Scientific Data, Scientific Reports
?
Reviewer für nationale und internationale wissenschaftliche F?rderorganisationen wie die Alexander von Humboldt-Stiftung, Agence National de la Recherche, Association for International Cancer Research, Croatian Science Foundation, Czech Science Foundation, Deutsche Forschungsgemeinschaft, Deutsche Krebshilfe, Deutsche Kinderkrebsstiftung, Dutch Research Council, Finnish Cancer Institute, Institute National du Cancer, The Research Foundation - Flanders, Wissenschaftsrat
PUBLIKATIONEN
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2025 |
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Etienne Sollier, Anna Riedel, Umut H. Toprak, Justyna A. Wierzbinska, Dieter Weichenhan, Jan Philipp Schmid, Mariam Hakobyan, Aurore Touzart, Ekaterina Jahn, Binje Vick, Fiona Brown-Burke, Katherine Kelly, Simge Kelekci, Anastasija Pejkovska, Ashish Goyal, Marion B?hr, Kersten Breuer, Mei-Ju May Chen, Maria Llamazares-Prada, Mark Hartmann, Maximilian Sch?nung, Nadia Correia, Andreas Trumpp, Yomn Abdullah, Ursula Klingmüller, Sadaf S. Mughal, Benedikt Brors, Frank Westermann, Elias Ulrich, Robert J. Autry, Matthias Schlesner, Sebastian Vosberg, Tobias Herold, Philipp A. Greif, Dietmar Pfeifer, Michael Lübbert, Thomas Fischer, Florian H. Heidel, Claudia Gebhard, Wencke Walter, Torsten Haferlach, Ann-Kathrin Eisfeld, Krzysztof Mrózek, Deedra Nicolet, Lars Bullinger, Leonie Smeenk, Claudia Erpelinck-Verschueren, Roger Mulet-Lazaro, Ruud Delwel, Aurélie Ernst, Michael Scherer, Pavlo Lutsik, Irmela Jeremias, Konstanze D?hner, Hartmut D?hner, Daniel B. Lipka and Christoph Plass. in press. Enhancer hijacking discovery in acute myeloid leukemia by pyjacker identifies MNX1 activation via deletion 7q. DOI: 10.1158/2643-3230.bcd-24-0278 |
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Areeba Patel, Kirsten G?bel, Sebastian Ille, Felix Hinz, Natalie Schoebe, Henri Bogumil, Jochen Meyer, Michelle Brehm, Helin Kardo, Daniel Schrimpf, Artem Lomakin, Michael Ritter, Pauline G?ller, Paul Kerbs, Lisa Pfeifer, Stefan Hamelmann, Christina Blume, Franziska M. Ippen, Natalie Berghaus, Philipp Euskirchen, Leonille Schweizer, Claus Hultschig, Nadine Van Roy, Jo Van Dorpe, Joni Van der Meulen, Siebe Loontiens, Franceska Dedeurwaerdere, Henning Leske, Skarphé?inn Halldórsson, Graeme Fox, Simon Deacon, Inswasti Cahyani, Nadine Holmes, Satrio Wibowo, Rory Munro, Dan Martin, Abid Sharif, Mark Housley, Robert Goldspring, Sebastian Brandner, Somak Roy, Jürgen Hench, Stephan Frank, Andreas Unterberg, Violaine Goidts, Natalie J?ger, Simon Paine, Stuart Smith, Christel Herold-Mende, Wolfgang Wick, Stefan M. Pfister, Einar O. Vik-Mo, Andreas von Deimling, Sandro Krieg, David T. W. Jones, Matthew Loose, Matthias Schlesner, Martin Sill and Felix Sahm. in press. Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors. DOI: 10.1038/s41591-025-03562-5 |
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Teng-Feng Li, Paul Rothhaar, Arthur Lang, Oliver Grünvogel, Ombretta Colasanti, Santa Mariela Olivera Ugarte, Jannik Traut, Antonio Piras, Nelson Acosta-Rivero, Vladimir Gon?alves Magalh?es, Emely Springer, Andreas Betz, Hao-En Huang, Jeongbin Park, Ruiyue Qiu, Gnimah Eva Gnouamozi, Ann-Kathrin Mehnert, Viet Loan Dao Thi, Stephan Urban, Martina Muckenthaler, Matthias Schlesner, Dirk Wohlleber, Marco Binder, Ralf Bartenschlager, Andreas Pichlmair and Volker Lohmann. 2025. RBM39 shapes innate immunity by controlling the expression of key factors of the interferon response. DOI: 10.3389/fimmu.2025.1568056 |
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Andreas Betz, Hao-En Huang, Zuguang Gu, Ombretta Colasanti, Teng-Feng Li, Jasper Hesebeck-Brinckmann, Nadine Gillich, Gnimah Eva Gnouamozi, Matthias Schlesner, Florian W. R. Vondran, Stephan Urban, Ralf Bartenschlager, Marco Binder and Volker Lohmann. in press. Reconstitution of interferon regulatory factor 7 expression restores interferon beta induction in Huh7 cells. DOI: 10.1128/jvi.00703-25 |
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Selina Glaser, Anja Fischer, Juan Emilio Martínez-Manjón, Cristina López, Helene Kretzmer, Birgit Burkhardt, Daniel Hübschmann, Michael Hummel, Wolfram Klapper, Julia Kolarova, Markus Kreuz, German Ott, Bernhard Radlwimmer, Maciej Rosolowski, Matthias Schlesner, Andreas Rosenwald, Stephan Stilgenbauer, Rabea Wagener, Igor Zwir, Lorenz Trümper, Ralf Küppers, Peter Lichter, Ole Ammerpohl, Coral del Val and Reiner Siebert. in press. Subgrouping germinal center-derived B-cell lymphomas based on machine learning-deduced DNA methylation modules [Letter]. DOI: 10.1038/s41375-025-02533-6 |
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Selina Glaser, Rabea Wagener, Helene Kretzmer, Cristina López, Maria Joao Baptista, Susanne Bens, Stephan Bernhart, Kishor Bhatia, Arndt Borkhardt, Shaymaa Elgaafary, Steve Hoffmann, Daniel Hübschmann, Michael Hummel, Wolfram Klapper, Julia Kolarova, Markus Kreuz, Stefano Lazzi, Markus L?ffler, Jose Tomas Navarro, Janet Neequaye, Noel Onyango, Timothy Onyuma, German Ott, Bernhard Radlwimmer, Marius Rohde, Andreas Rosenwald, Maciej Rosolowski, Matthias Schlesner, Monika Szczepanowski, Gustavo Tapia, Wilhelm W??mann, Ralf Küppers, Lorenz Trümper, Lorenzo Leoncini, Peter Lichter, Coral del Val, Ole Ammerpohl, Birgit Burkhardt, Sam M. Mbulaiteye and Reiner Siebert. 2025. Subtyping Burkitt lymphoma by DNA methylation. DOI: 10.1002/gcc.70042 |
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Anagh A. Sahasrabuddhe, Xiaofei Chen, Kaiyu Ma, Rui Wu, Huan-Chang Liang, Richa Kapoor, Rishi R. Chhipa, Ozlem Onder, Courtney McFetridge, John S. Van Arnam, Xiao Zhang, Jennifer J. D. Morrissette, Vinodh Pillai, Marilyn M. Li, Philippe Szankasi, Venkatesha Basrur, Kevin P. Conlon, Tobias D. Raabe, Nathanael G. Bailey, Cory M. Hogaboam, Robert Rottapel, Junhyong Kim, Cristina López, Matthias Schlesner, Reiner Siebert, Kostiantyn Dreval, Ryan D. Morin, Loredana Moro, Michele Pagano, Louis M. Staudt, Megan S. Lim and Kojo S. J. Elenitoba-Johnson. 2025. The FBXO45-GEF-H1 axis controls germinal center formation and B-cell lymphomagenesis. DOI: 10.1158/2159-8290.cd-24-0442 |
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Stephanie Gehrs, Moritz Jakab, Ewgenija Gutjahr, Zuguang Gu, Dieter Weichenhan, Jan-Philipp Mallm, Carolin Mogler, Matthias Schlesner, Christoph Plass, Katharina Schlereth and Hellmut G. Augustin. in press. The spatial zonation of the murine placental vasculature is specified by epigenetic mechanisms. DOI: 10.1016/j.devcel.2024.12.037 |
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2024 |
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Ling Hai, Dirk C. Hoffmann, Robin J. Wagener, Daniel D. Azorin, David Hausmann, Ruifan Xie, Magnus-Carsten Huppertz, Julien Hiblot, Philipp Sievers, Sophie Heuer, Jakob Ito, Gina Cebulla, Alexandros Kourtesakis, Leon D. Kaulen, Miriam Ratliff, Henriette Mandelbaum, Erik Jung, Ammar Jabali, Sandra Horschitz, Kati J. Ernst, Denise Reibold, Uwe Warnken, Varun Venkataramani, Rainer Will, Mario L. Suvà, Christel Herold-Mende, Felix Sahm, Frank Winkler, Matthias Schlesner, Wolfgang Wick and Tobias Kessler. 2024. A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1. DOI: 10.1038/s41467-024-45067-8 |
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Victoria Fincke, Maurice Lossner, Irmengard Sax, Marlena Mucha, Felix Dorn, Stefan Wudy, Christian Vokuhl, Rainer Claus, Marina Kunstreich, Christoph Slavetinsky, Jorg Fuchs, Matthias Schlesner, Michael Frühwald, Antje Redlich, Michaela Kuhlen and Pascal Johann. 2024. Analysis of DNA methylation profiles and single nuclei RNA-seq of pediatric adrenocortical tumors reveal subgroups of clinical relevance and distinct tumor biology [Abstract]. DOI: 10.1530/endoabs.99.ep27 |
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Victoria E. Fincke, Mona Steinbügl, Hye-Jung E. Chun, Karolina Nemes, Marlena Mucha, Maurice Lo?ner, Felix Dorn, Katharina Gastberger, Sebastian Bühner, Martin Sill, Thomas Kr?ncke, Reiner Siebert, Patrick Melchior, Rhoikos Furtw?ngler, Matthias Schlesner, Christian Vokuhl, Christoph R?cken, Pascal D. Johann and Michael C. Frühwald. 2024. Clinical and molecular risk factors in extracranial malignant rhabdoid tumors: toward an integrated model of high-risk tumors. DOI: 10.1158/1078-0432.ccr-23-3489 |
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Sebastian Sommer, Maximilian Schmutz, Kathrin Hildebrand, Annett Schiwitza, Selinah Benedikt, Maria Eberle, Tatiana M?gele, Aziz Sultan, Lena Reichl, Maria Campillo, Luise Uhrmacher, Ana Antic Nikolic, Ralph Bundschuh, Constantin Lapa, Michaela Kuhlen, Sebastian Dintner, Angela Langer, Bruno M?rkl, Thomas Wendler, Kartikay Tehlan, Thomas Kr?ncke, Maria Wahle, Matthias Mann, Nicolas Casadei, Michaela Pogoda, Simone Hummler, Irmengard Sax, Matthias Schlesner, Boris Kubuschok, Martin Trepel and Rainer Claus. 2024. Concept and feasibility of the Augsburg Longitudinal Plasma Study (ALPS) - a prospective trial for comprehensive liquid biopsy-based longitudinal monitoring of solid cancer patients. DOI: 10.1515/labmed-2023-0156 |
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Philipp A. Toussaint, Florian Leiser, Scott Thiebes, Matthias Schlesner, Benedikt Brors and Ali Sunyaev. 2024. Explainable artificial intelligence for omics data: a systematic mapping study. DOI: 10.1093/bib/bbad453 |
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Selina Glaser, Helene Kretzmer, Iris?Tatjana Kolassa, Matthias Schlesner, Anja Fischer, Isabell Fenske, Reiner Siebert and Ole Ammerpohl. 2024. Navigating Illumina DNA methylation data: biology versus technical artefacts. DOI: 10.1093/nargab/lqae181 |
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Areeba J. Patel, Kirsten G?bel, Felix Hinz, Helin Dogan, Daniel Schrimpf, Pauline G?ller, Henning Leske, Skarphé?inn Halldórsson, Graeme Fox, Simon Deacon, Simon Paine, Stuart Smith, Natalie J?ger, Christel Herold-Mende, Wolfgang Wick, Stefan M. Pfister, Einar Vik-Mo, Andreas von Deimling, Matthias Schlesner, David T. W. Jones, Matthew Loose, Martin Sill and Felix Sahm. 2024. PATH-10. Accelerating comprehensive CNS tumor molecular diagnostics with Rapid-CNS2 and MNP-flex: a prospective multi-center validation [Abstract]. DOI: 10.1093/neuonc/noae064.713 |
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Sophie Heuer, Ina Burghaus, Maria Gose, Tobias Kessler, Felix Sahm, Philipp Vollmuth, Varun Venkataramani, Dirk Hoffmann, Matthias Schlesner, Miriam Ratliff, Carsten Hopf, Ulrich Herrlinger, Franz Ricklefs, Martin Bendszus, Sandro M. Krieg, Antje Wick, Wolfgang Wick and Frank Winkler. 2024. PerSurge (NOA-30) phase II trial of perampanel treatment around surgery in patients with progressive glioblastoma. DOI: 10.1186/s12885-024-11846-1 |
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Yu-Yu Lin, Kersten Breuer, Dieter Weichenhan, Pascal Lafrenz, Agata Wilk, Marina Chepeleva, Oliver Mücke, Maximilian Sch?nung, Franziska Petermann, Philipp Kensche, Lena Weiser, Frank Thommen, Gideon Giacomelli, Karl Nordstroem, Edahi Gonzalez-Avalos, Angelika Merkel, Helene Kretzmer, Jonas Fischer, Stephen Kr?mer, Murat Iskar, Stephan Wolf, Ivo Buchhalter, Manel Esteller, Chris Lawerenz, Sven Twardziok, Marc Zapatka, Volker Hovestadt, Matthias Schlesner, Marcel Schulz, Steve Hoffmann, Clarissa Gerhauser, J?rn Walter, Mark Hartmann, Daniel B. Lipka, Yassen Assenov, Christoph Bock, Christoph Plass, Reka Toth and Pavlo Lutsik. in press. Pipeline Olympics: continuable benchmarking of computational workflows for DNA methylation sequencing data against an experimental gold standard. DOI: 10.1101/2024.09.16.609142 |
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Etienne Sollier, Anna Riedel, Umut H. Toprak, Justyna A. Wierzbinska, Dieter Weichenhan, Jan Philipp Schmid, Mariam Hakobyan, Aurore Touzart, Ekaterina Jahn, Binje Vick, Fiona Brown-Burke, Katherine Kelly, Simge Kelekci, Anastasija Pejkovska, Ashish Goyal, Marion B?hr, Kersten Breuer, Mei-Ju May Chen, Maria Llamazares-Prada, Mark Hartmann, Maximilian Sch?nung, Nádia Correia, Andreas Trumpp, Yomn Abdullah, Ursula Klingmüller, Sadaf S. Mughal, Benedikt Brors, Frank Westermann, Matthias Schlesner, Sebastian Vosberg, Tobias Herold, Philipp A. Greif, Dietmar Pfeifer, Michael Lübbert, Thomas Fischer, Florian H. Heidel, Claudia Gebhard, Wencke Walter, Torsten Haferlach, Ann-Kathrin Eisfeld, Krzysztof Mrózek, Deedra Nicolet, Lars Bullinger, Leonie Smeenk, Claudia Erpelinck, Roger Mulet-Lazaro, Ruud Delwel, Aurélie Ernst, Michael Scherer, Pavlo Lutsik, Irmela Jeremias, Konstanze D?hner, Hartmut D?hner, Daniel B. Lipka and Christoph Plass. in press. Pyjacker identifies enhancer hijacking events in acute myeloid leukemia including MNX1 activation via deletion 7q. DOI: 10.1101/2024.09.11.611224 |
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Areeba Patel, Kirsten G?bel, Felix Hinz, Helin Dogan, Daniel Schrimpf, Pauline G?ller, Henning Leske, Skarpheoinn Halldórsson, Graeme Fox, Simon Deacon, Simon Paine, Stuart Smith, Natalie J?ger, Christel Herold-Mende, Wolfgang Wick, Stefan Pfister, Einar Vik-Mo, Andreas von Deimling, Matthias Schlesner, David T. Jones, Matthew Loose, Martin Sill and Felix Sahm. 2024. Rapid-CNS2 combined with MNP-Flex enables next-day comprehensive molecular diagnostic profiling of CNS tumors in a global cohort [Abstract]. DOI: 10.1016/S1525-1578(24)00122-3 |
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Bianca Grosser, Christian M. Heyer, Johannes Austgen, Eva Sipos, Nic G. Reitsam, Andreas Hauser, Alison VanSchoiack, David Kroeppler, Dmytro Vlasenko, Andreas Probst, Alexander Novotny, Wilko Weichert, Gisela Keller, Matthias Schlesner and Bruno M?rkl. 2024. Stroma AReactive Invasion Front Areas (SARIFA) proves prognostic relevance in gastric carcinoma and is based on a tumor–adipocyte interaction indicating an altered immune response. DOI: 10.1007/s10120-023-01436-8 |
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Till Seiboldt, Constantia Zeiser, Duy Nguyen, Simay Celikyürekli, Sonja Herter, Sara Najafi, Alexandra Stroh-Dege, Chris Meulenbroeks, Norman Mack, Rabia Salem-Altintas, Frank Westermann, Matthias Schlesner, Till Milde, Marcel Kool, Tim Holland-Letz, Meike Vogler, Heike Peterziel, Olaf Witt and Ina Oehme. 2024. Synergy of retinoic acid and BH3 mimetics in MYC(N)-driven embryonal nervous system tumours. DOI: 10.1038/s41416-024-02740-5 |
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Sandrine Jayne, Cristina López, Natalie Put, Inga Nagel, Els Lierman, Eva Maria Murga Penas, Lucienne Michaux, Matthew J. Ahearne, Harriet S. Walter, Susanne Bens, Cosima Drewes, Monika Szczepanowski, Matthias Schlesner, Philip Rosenstiel, Iwona Wlodarska, Reiner Siebert and Martin J. S. Dyer. 2024. The chromosomal translocation t(1;6)(p35.3;p25.2), recurrent in chronic lymphocytic leukaemia, leads to RCC1::IRF4 fusion. DOI: 10.1111/bjh.19790 |
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Marit M. Grimsrud, Michael Forster, Benjamin Goeppert, Georg Hemmrich-Stanisak, Irmi Sax, Krzysztof Grzyb, Peder R. Braadland, Alphonse Charbel, Carmen Metzger, Thomas Albrecht, Tim Alexander Steiert, Matthias Schlesner, Michael P. Manns, Arndt Vogel, Sheraz Yaqub, Tom H. Karlsen, Peter Schirmacher, Kirsten M. Boberg, Andre Franke, Stephanie Roessler and Trine Folseraas. 2024. Whole-exome sequencing reveals novel cancer genes and actionable targets in biliary tract cancers in primary sclerosing cholangitis. DOI: 10.1097/hc9.0000000000000461 |
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2023 |
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M. Renner, M. Ole?, N. Paramasivam, A. Schneider, C. E. Heilig, C. Modugno, C. Herremans, A. Mock, D. Lipka, S. Bauer, T. Kindler, C. H. Brandts, U. Keilholz, M. Boerries, B. Kuster, D. Hübschmann, Matthias Schlesner, H. Glimm, R. F. Schlenk and S. Fr?hling. 2023. 1936P Targeted therapy of desmoplastic small round cell tumor guided by multilayered molecular profiling [Abstract]. DOI: 10.1016/j.annonc.2023.09.1165 |
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Dirk Hoffmann, Ling Hai, Robin Wagener, David Hausmann, Daniel Domínguez Azorín, Ruifan Xie, Magnus-Carsten Huppertz, Julien Hiblot, Philipp Sievers, Jakob Ito, Sophie Weil, Gina Cebulla, Henriette Mandelbaum, Erik Jung, Alexandros Kourtesakis, Kati Ernst, Denise Reibold, Uwe Warnken, Varun Venkataramani, Rainer Will, Mario Suva, Christel Herold-Mende, Felix Sahm, Frank Winkler, Matthias Schlesner, Wolfgang Wick and Tobias Kessler. 2023. CNSC-09 CHI3L1 is amolecular marker for gliobastoma network connectivity and functionally orchestrates tumor microtube formation [Abstract]. DOI: 10.1093/neuonc/noad179.0093 |
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Maximilian Sch?nung, Mark Hartmann, Stephen Kr?mer, Sina St?ble, Mariam Hakobyan, Emely Kleinert, Theo Aurich, Defne Cobanoglu, Florian H. Heidel, Stefan Fr?hling, Michael D. Milsom, Matthias Schlesner, Pavlo Lutsik and Daniel B. Lipka. 2023. Dynamic DNA methylation reveals novel cis-regulatory elements in mouse hematopoiesis. DOI: 10.1016/j.exphem.2022.11.001 |
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Yasmeen Niazi, Nagarajan Paramasivam, Joanna Blocka, Abhishek Kumar, Stefanie Huhn, Matthias Schlesner, Niels Weinhold, Rolf Sijmons, Mirjam De Jong, Brian Durie, Hartmut Goldschmidt, Kari Hemminki and Asta F?rsti. 2023. Investigation of rare non-coding variants in familial multiple myeloma. DOI: 10.3390/cells12010096 |
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Weiyin Zhou, Anja Fischer, Martin D. Ogwang, Wen Luo, Patrick Kerchan, Steven J. Reynolds, Constance N. Tenge, Pamela A. Were, Robert T. Kuremu, Walter N. Wekesa, Nestory Masalu, Esther Kawira, Tobias Kinyera, Isaac Otim, Ismail D. Legason, Hadijah Nabalende, Leona W. Ayers, Kishor Bhatia, James J. Goedert, Mateus H. Gouveia, Nathan Cole, Belynda Hicks, Kristine Jones, Michael Hummel, Matthias Schlesner, George Chagaluka, Nora Mutalima, Eric Borgstein, George N. Liomba, Steve Kamiza, Nyengo Mkandawire, Collins Mitambo, Elizabeth M. Molyneux, Robert Newton, Selina Glaser, Helene Kretzmer, Michelle Manning, Amy Hutchinson, Ann W. Hsing, Yao Tettey, Andrew A. Adjei, Stephen J. Chanock, Reiner Siebert, Meredith Yeager, Ludmila Prokunina-Olsson, Mitchell J. Machiela and Sam M. Mbulaiteye. 2023. Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa. DOI: 10.1038/s41467-023-43881-0 |
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Mark Hartmann, Maximilian Sch?nung, Jovana Rajak, Joschka Hey, Valentin Maurer, Ling Hai, Sina Staeble, Jens Langstein, Katharina Bauer, Mariam Hakobyan, Laura Jardine, Sheila Bohler, Dominik Vonficht, Abdul-Habib Maag, Dirk Lebrecht, Katrin M. Bernt, Roland Roelz, Tobias Boch, Eleonora Khabirova, Pavlo Lutsik, Simon Haas, Muzlifah Haniffa, Sam Behjati, Jan-Philipp Mallm, Christian Buske, Michael D. Milsom, Stefan Fr?hling, Marc-Jan Bonder, Charlotte Niemeyer, Christian Flotho, Christoph Plass, Miriam Erlacher, Matthias Schlesner and Daniel B. Lipka. 2023. OC 34 - Onco-fetal programming drives high-risk juvenile myelomonocytic leukemia, which can be targeted by anti-CD52 treatment [Abstract]. DOI: 10.1016/j.ejcped.2023.100065 |
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Heike Peterziel, Nora Jamaladdin, Dina ElHarouni, Xenia F. Gerloff, Sonja Herter, Petra Fiesel, Yannick Berker, Mirjam Blattner-Johnson, Kathrin Schramm, Barbara C. Jones, David Reuss, Laura Turunen, Aileen Friedenauer, Tim Holland-Letz, Martin Sill, Lena Weiser, Christopher Previti, Gnanaprakash Balasubramanian, Nicolas U. Gerber, Johannes Gojo, Caroline Hutter, Ingrid ?ra, Olli Lohi, Antonis Kattamis, Bram de Wilde, Frank Westermann, Stephan Tippelt, Norbert Graf, Michaela Nathrath, Monika Sparber-Sauer, Astrid Sehested, Christof M. Kramm, Uta Dirksen, Olli Kallioniemi, Stefan M. Pfister, Cornelis M. van Tilburg, David T. W. Jones, Jani Saarela, Vilja Pieti?inen, Natalie J?ger, Matthias Schlesner, Annette Kopp-Schneider, Sina Oppermann, Till Milde, Olaf Witt and Ina Oehme. 2023. OTHR-04. Development of a functional plattform for real-time personalized drug sensitivity profiling of patient-derived 3D fresh tumor tissue cultures in the pediatric precision oncology program INFORM [Abstract]. DOI: 10.1093/neuonc/noad073.286 |
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Mark Hartmann, Maximilian Sch?nung, Jovana Rajak, Valentin Maurer, Ling Hai, Katharina Bauer, Mariam Hakobyan, Sina Staeble, Jens Langstein, Laura Jardine, Roland R?lz, Sheila Bohler, Eleonora Khabirova, Abdul-Habib Maag, Dominik Vonficht, Dirk Lebrecht, Katrin M. Bernt, Kai Tan, Changya Chen, Fatemeh Alikarami, Tobias Boch, Viktoria Flore, Pavlo Lutsik, Michael D. Milsom, Simon Raffel, Christian Buske, Simon Haas, Muzlifah Haniffa, Jan-Philipp Mallm, Sam Behjati, Marc-Jan Bonder, Stefan Fr?hling, Charlotte M. Niemeyer, Joschka Hey, Christian Flotho, Christoph Plass, Miriam Erlacher, Matthias Schlesner and Daniel B. Lipka. in press. Oncogenic RAS-pathway activation drives oncofetal reprogramming and creates therapeutic vulnerabilities in juvenile myelomonocytic leukemia. DOI: 10.1101/2023.10.27.563754 |
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Sebastian Sommer, Maximilian Schmutz, S. Benedikt, I. Sax, Sebastian Dintner, M. Eberle, A. Langer, Bruno M?rkl, S. Hummler, Matthias Schlesner, Boris Kubuschok, Martin Trepel and Rainer Claus. 2023. P703 Assessment of genetic tumor profiles and clonal evolution by liquid biopsy: the Augsburg Longitudinal Plasma Study (ALPS) [Abstract]. DOI: 10.1159/000533576 |
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Teng-Feng Li, Paul Rothhaar, Arthur Lang, Oliver Grünvogel, Ombretta Colasanti, Santa Mariela Olivera Ugarte, Jannik Traut, Antonio Piras, Nelson Acosta-Rivero, Vladimir Gon?alves Magalh?es, Emely Springer, Andreas Betz, Hao-En Huang, Jeongbin Park, Ruiyue Qiu, Gnimah Eva Gnouamozi, Ann-Kathrin Mehnert, Viet Loan Dao Thi, Stephan Urban, Martina Muckenthaler, Matthias Schlesner, Dirk Wohlleber, Marco Binder, Ralf Bartenschlager, Andreas Pichlmair and Volker Lohmann. in press. RBM39 shapes innate immunity through transcriptional and splicing control of key factors of the interferon response. DOI: 10.1101/2023.10.13.562221 |
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Verena Turco, Kira Pfleiderer, Jessica Hunger, Natalie K. Horvat, Kianush Karimian-Jazi, Katharina Schregel, Manuel Fischer, Gianluca Brugnara, Kristine J?hne, Volker Sturm, Yannik Streibel, Duy Nguyen, Sandro Altamura, Dennis A. Agardy, Shreya S. Soni, Abdulrahman Alsasa, Theresa Bunse, Matthias Schlesner, Martina U. Muckenthaler, Ralph Weissleder, Wolfgang Wick, Sabine Heiland, Philipp Vollmuth, Martin Bendszus, Christopher B. Rodell, Michael O. Breckwoldt and Michael Platten. 2023. T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles. DOI: 10.1038/s41467-023-36321-6 |
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Lars Buschhorn, Dorett I. Odoni, Johanna Geuder, Timo O. Odinius, Celina V. Wagner, Stefanie Jilg, Ulrike H?ckendorf, Adam Wahida, Matthias Schlesner, Andreas Reiter, Mohamad Jawhar and Philipp J. Jost. 2023. Transcriptomic profiling does not refine mastocytosis diagnosis. DOI: 10.3324/haematol.2022.282617 |
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Dieter Weichenhan, Anna Riedel, Charlotte Meinen, Alisa Basic, Reka Toth, Marion B?hr, Pavlo Lutsik, Joschka Hey, Etienne Sollier, Umut H. Toprak, Simge Kelek?i, Yu-Yu Lin, Mariam Hakobyan, Aurore Touzart, Ashish Goyal, Justyna A. Wierzbinska, Matthias Schlesner, Frank Westermann, Daniel B. Lipka and Christoph Plass. 2023. Translocation t(6;7) in AML-M4 cell line GDM-1 results in MNX1 activation through enhancer-hijacking. DOI: 10.1038/s41375-023-01865-5 |
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Enrique Blanco-Carmona, Ashwin Narayanan, Inmaculada Hernandez, Juan C. Nieto, Marc Elosua-Bayes, Xueyuan Sun, Claudia Schmidt, Necmettin Pamir, Koray ?zduman, Christel Herold-Mende, Francesca Pagani, Manuela Cominelli, Julian Taranda, Wolfgang Wick, Andreas von Deimling, Pietro Luigi Poliani, Michael Rehli, Matthias Schlesner, Holger Heyn and ?evin Turcan. 2023. Tumor heterogeneity and tumor-microglia interactions in primary and recurrent IDH1-mutant gliomas. DOI: 10.1016/j.xcrm.2023.101249 |
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M. Hartmann, M. Schonung, J. Rajak, J. Hey, V. Maurer, L. Hai, S. Staeble, J. Langstein, K. Bauer, M. Hakobyan, L. Jardine, S. Bohler, D. Vonficht, A. H. Maag, D. Lebrecht, K. M. Bernt, R. Roelz, T. Boch, E. Khabirova, P. Lutsik, S. Haas, A. M. Hani, S. Behjati, J.-P. Mallm, C. Buske, M. D. Milsom, S. Frohling, M.-J. Bonder, C. Niemeyer, C. Flotho, C. Plass, M. Erlacher, Matthias Schlesner and D. B. Lipka. 2023. V849 Onco-fetal reprogramming in juvenile myelomonocytic leukemia upregulates surface markers which can be exploited as therapeutic targets [Abstract]. DOI: 10.1159/000533576 |
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2022 |
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Mikael Beyene, Philipp A. Toussaint, Scott Thiebes, Matthias Schlesner, Benedikt Brors and Ali Sunyaev. 2022. A scoping review of distributed ledger technology in genomics: thematic analysis and directions for future research. DOI: 10.1093/jamia/ocac077 |
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David Hausmann, Dirk C. Hoffmann, Varun Venkataramani, Erik Jung, Sandra Horschitz, Svenja K. Tetzlaff, Ammar Jabali, Ling Hai, Tobias Kessler, Daniel D. Azo?in, Sophie Weil, Alexandros Kourtesakis, Philipp Sievers, Antje Habel, Michael O. Breckwoldt, Matthia A. Karreman, Miriam Ratliff, Julia M. Messmer, Yvonne Yang, Ekin Reyhan, Susann Wendler, Cathrin L?b, Chanté Mayer, Katherine Figarella, Matthias Osswald, Gergely Solecki, Felix Sahm, Olga Garaschuk, Thomas Kuner, Philipp Koch, Matthias Schlesner, Wolfgang Wick and Frank Winkler. 2022. Autonomous rhythmic activity in glioma networks drives brain tumour growth. DOI: 10.1038/s41586-022-05520-4 |
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Nicola Giesen, Nagarajan Paramasivam, Umut H. Toprak, Daniel Huebschmann, Jing Xu, Sebastian Uhrig, Mehmet Samur, Stella B?hr, Martina Fr?hlich, Sadaf S. Mughal, Elias K. Mai, Anna Jauch, Carsten Müller-Tidow, Benedikt Brors, Nikhil Munshi, Hartmut Goldschmidt, Niels Weinhold, Matthias Schlesner and Marc S. Raab. 2022. Comprehensive genomic analysis of refractory multiple myeloma reveals a complex mutational landscape associated with drug resistance and novel therapeutic vulnerabilities. DOI: 10.3324/haematol.2021.279360 |
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Melinda Czeh, Sina St?ble, Stephen Kr?mer, Lena Tepe, Sweta Talyan, Joana Carrelha, Yiran Meng, Barbara Heitplatz, Marius Schwabenland, Michael D. Milsom, Christoph Plass, Marco Prinz, Matthias Schlesner, Miguel A. Andrade-Navarro, Claus Nerlov, Sten Eirik W. Jacobsen, Daniel B. Lipka and Frank Rosenbauer. 2022. DNMT1 deficiency impacts on plasmacytoid dendritic cells in homeostasis and autoimmune disease. DOI: 10.4049/jimmunol.2100624 |
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Marina Laplana, Matthias Bieg, Christian Faltus, Svitlana Melnik, Olga Bogatyrova, Zuguang Gu, Thomas Muley, Michael Meister, Hendrik Dienemann, Esther Herpel, Christopher I. Amos, Matthias Schlesner, Roland Eils, Christoph Plass and Angela Risch. 2022. Differentially methylated regions within lung cancer risk loci are enriched in deregulated enhancers. DOI: 10.1080/15592294.2021.1878723 |
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Heike Peterziel, Nora Jamaladdin, Dina ElHarouni, Xenia F. Gerloff, Sonja Herter, Petra Fiesel, Yannick Berker, Mirjam Blattner-Johnson, Kathrin Schramm, Barbara C. Jones, David Reuss, Laura Turunen, Aileen Friedenauer, Tim Holland-Letz, Martin Sill, Lena Weiser, Christopher Previti, Gnanaprakash Balasubramanian, Nicolas U. Gerber, Johannes Gojo, Caroline Hutter, Ingrid ?ra, Olli Lohi, Antonis Kattamis, Bram de Wilde, Frank Westermann, Stephan Tippelt, Norbert Graf, Michaela Nathrath, Monika Sparber-Sauer, Astrid Sehested, Christof M. Kramm, Uta Dirksen, Olli Kallioniemi, Stefan M. Pfister, Cornelis M. van Tilburg, David T. W. Jones, Jani Saarela, Vilja Pieti?inen, Natalie J?ger, Matthias Schlesner, Annette Kopp-Schneider, Sina Oppermann, Till Milde, Olaf Witt and Ina Oehme. 2022. Drug sensitivity profiling of 3D tumor tissue cultures in the pediatric precision oncology program INFORM. DOI: 10.1038/s41698-022-00335-y |
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Paurnima Patil, Umut H. Toprak, Julian Seufert, Till Braun, Stephan H. Bernhart, Laura Wiehle, Annika Müller, Matthias Schlesner, Marco Herling, Peter Lichter, Stephan Stilgenbauer, Reiner Siebert and Marc Zapatka. 2022. Exploration of whole genome and transcriptome sequencing data lacks evidence for oncogenic viral elements to drive the pathogenesis of T-cell prolymphocytic leukemia. DOI: 10.1080/10428194.2022.2116933 |
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Cristina Lopez, Nikolai Schleussner, Stephan H. Bernhart, Kortine Kleinheinz, Stephanie Sungalee, Henrike L. Sczakiel, Helene Kretzmer, Umut H. Toprak, Selina Glaser, Rabea Wagener, Ole Ammerpohl, Susanne Bens, Maciej Giefing, Juan C. Gonzalez Sanchez, Gordana Apic, Daniel Hubschmann, Martin Janz, Markus Kreuz, Anja Mottok, Judith M. Muller, Julian Seufert, Steve Hoffmann, Jan O. Korbel, Robert B. Russell, Roland Schule, Lorenz Trumper, Wolfram Klapper, Bernhard Radlwimmer, Peter Lichter, Ralf Kuppers, Matthias Schlesner, Stephan Mathas and Reiner Siebert. 2022. Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B cell lymphomas. DOI: 10.3324/haematol.2021.280005 |
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Lizhen Zhu, Beiping Miao, Dagmara Dymerska, Magdalena Kuswik, Elena Bueno-Martínez, Lara Sanoguera-Miralles, Eladio A. Velasco, Nagarajan Paramasivam, Matthias Schlesner, Abhishek Kumar, Ying Yuan, Jan Lubinski, Obul Reddy Bandapalli, Kari Hemminki and Asta F?rsti. 2022. Germline variants of CYBA and TRPM4 predispose to familial colorectal cancer. DOI: 10.3390/cancers14030670 |
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Weiyin Zhou, Anja Pfaus, Martin Ogwang, Wen Luo, Patrick Kerchan, Steven Reynolds, Constance N. Tenge, Pamela A. Were, Robert T. Kuremu, Walter N. Wekesa, Nestory Masalu, Esther Kawira, Tobias Kinyera, Isaac Otim, Ismail D. Legason, Hadijah Nabalende, Leona W. Ayers, Kishor Bhatia, James J. G?dert, Nathan Cole, Belynda Hicks, Kristine Jones, Michael Hummel, Matthias Schlesner, George Chagaluka, Nora Mutalima, Eric Borgstein, George N. Liomba, Steve Kamiza, Nyengo Mkandawire, Collins Mitambo, Elizabeth Molyneux, Robert Newton, Selina Glaser, Michelle Manning, Amy Hutchinson, Ann W. Hsing, Yao Tettey, Andrew Anthony Adjei, Stephen J. Chanock, Reiner Siebert, Meredith Yeager, Mitchell Machiela and Sam M. Mbulaiteye. 2022. Increased frequency of mosaic chromosomal alterations in peripheral blood samples of Sub-Saharan African children with endemic Burkitt lymphoma [Abstract]. DOI: 10.1182/blood-2022-169500 |
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Ruzhica Bogeska, Ana-Matea Mikecin, Paul Kaschutnig, Malak Fawaz, Marleen Büchler-Sch?ff, Duy Le, Miguel Ganuza, Angelika Vollmer, Stella V. Paffenholz, Noboru Asada, Esther Rodriguez-Correa, Felix Frauhammer, Florian Buettner, Melanie Ball, Julia Knoch, Sina St?ble, Dagmar Walter, Amelie Petri, Martha J. Carre?o-Gonzalez, Vinona Wagner, Benedikt Brors, Simon Haas, Daniel B. Lipka, Marieke A.G. Essers, Vivienn Weru, Tim Holland-Letz, Jan-Philipp Mallm, Karsten Rippe, Stephan Kr?mer, Matthias Schlesner, Shannon McKinney Freeman, Maria Carolina Florian, Katherine Y. King, Paul S. Frenette, Michael A. Rieger and Michael D. Milsom. 2022. Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging. DOI: 10.1016/j.stem.2022.06.012 |
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Hamed Alborzinia, Andrés F. Flórez, Sina Kreth, Lena M. Brückner, Umut Yildiz, Moritz Gartlgruber, Dorett I. Odoni, Gernot Poschet, Karolina Garbowicz, Chunxuan Shao, Corinna Klein, Jasmin Meier, Petra Zeisberger, Michal Nadler-Holly, Matthias Ziehm, Franziska Paul, Jürgen Burhenne, Emma Bell, Marjan Shaikhkarami, Roberto Würth, Sabine A. Stainczyk, Elisa M. Wecht, Jochen Kreth, Michael Büttner, Naveed Ishaque, Matthias Schlesner, Barbara Nicke, Carlo Stresemann, María Llamazares-Prada, Jan H. Reiling, Matthias Fischer, Ido Amit, Matthias Selbach, Carl Herrmann, Stefan W?lfl, Kai-Oliver Henrich, Thomas H?fer, Andreas Trumpp and Frank Westermann. 2022. MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis. DOI: 10.1038/s43018-022-00355-4 |
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Mark Hartmann, Ling Hai, Joschka Hey, Maximilian Sch?nung, Valentin Maurer, Jovana Rajak, Sina St?ble, Jens Langstein, Katharina Bauer, Mariam Hakobyan, Laura Jardine, Sheila Bohler, Dominik Vonficht, Abdul-Habib Maag, Dirk Lebrecht, Kathrin M. Bernt, Roland R?lz, Tobias Boch, Eleonora Khabirova, Pavlo Lutsik, Oliver Stegle, Simon Haas, Muzlifah Haniffa, Sam Behjati, Jan-Philipp Mallm, Christian Buske, Stefan Fr?hling, Christoph Plass, Charlotte M. Niemeyer, Christian Flotho, Marc Jan Bonder, Miriam Erlacher, Matthias Schlesner and Daniel B. Lipka. 2022. Multi-omics profiling of JMML HSPCs reveals onco-fetal reprogramming and identifies novel prognostic biomarkers and therapeutic targets in high-risk JMML [Abstract]. DOI: 10.1182/blood-2022-162224 |
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Dina ElHarouni, Heike Peterziel, Kathrin Schramm, Till Milde, Sina Oppermann, Ina ?hme, Olaf Witt, Matthias Schlesner and Natalie Jager. 2022. Multiomics analysis of pediatric solid tumors within the INFORM precision oncology study: from functional drug profiling to biomarker identification [Abstract]. |
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Yannick Berker, Dina ElHarouni, Heike Peterziel, Petra Fiesel, Olaf Witt, Ina Oehme, Matthias Schlesner and Sina Oppermann. 2022. Patient-by-patient deep transfer learning for drug-response profiling using confocal fluorescence microscopy of pediatric patient-derived tumor-cell spheroids. DOI: 10.1109/tmi.2022.3205554 |
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Corinne Hübers, Ashik Ahmed Abdul Pari, Denise Grieshober, Martin Petkov, Alexander Schmidt, Tatjana Messmer, Christian Moritz Heyer, Sebastian Sch?lch, Stephanie S. Kapel, Nicolas Gengenbacher, Mahak Singhal, Benjamin Schieb, Claudine Fricke, Rainer Will, Kim Remans, Jochen Sven Utikal, Christoph Reissfelder, Matthias Schlesner, Kairbaan M. Hodivala-Dilke, Sander Kersten, Sergij Goerdt, Hellmut G. Augustin and Moritz Felcht. 2022. Primary tumor–derived systemic nANGPTL4 inhibits metastasis. DOI: 10.1084/jem.20202595 |
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Areeba Patel, Helin Dogan, Alexander Payne, Elena Krause, Philipp Sievers, Natalie Schoebe, Daniel Schrimpf, Christina Blume, Damian Stichel, Nadine Holmes, Philipp Euskirchen, Jürgen Hench, Stephan Frank, Violaine Rosenstiel-Goidts, Miriam Ratliff, Nima Etminan, Andreas Unterberg, Christoph Dieterich, Christel Herold-Mende, Stefan M. Pfister, Wolfgang Wick, Matthew Loose, Andreas von Deimling, Martin Sill, David T. W. Jones, Matthias Schlesner and Felix Sahm. 2022. Rapid-CNS2: rapid comprehensive adaptive nanopore-sequencing of CNS tumors, a proof-of-concept study. DOI: 10.1007/s00401-022-02415-6 |
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Josefine Radke, Naveed Ishaque, Randi Koll, Zuguang Gu, Elisa Schumann, Lina Sieverling, Sebastian Uhrig, Daniel Hübschmann, Umut H. Toprak, Cristina López, Xavier Pastor Hostench, Simone Borgoni, Dilafruz Juraeva, Fabienne Pritsch, Nagarajan Paramasivam, Gnana Prakash Balasubramanian, Matthias Schlesner, Shashwat Sahay, Marc Weniger, Debora Pehl, Helena Radbruch, Anja Osterloh, Agnieszka Korfel, Martin Misch, Julia Onken, Katharina Faust, Peter Vajkoczy, Dag Moskopp, Yawen Wang, Andreas J?dicke, Lorenz Trümper, Ioannis Anagnostopoulos, Dido Lenze, Ralf Küppers, Michael Hummel, Clemens A. Schmitt, Otmar D. Wiestler, Stephan Wolf, Andreas Unterberg, Roland Eils, Christel Herold-Mende, Benedikt Brors, Reiner Siebert, Stefan Wiemann and Frank L. Heppner. 2022. The genomic and transcriptional landscape of primary central nervous system lymphoma. DOI: 10.1038/s41467-022-30050-y |
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Paurnima Patil, Sina Hillebrecht, Emil Chteinberg, Cristina López, Umut H. Toprak, Julian Seufert, Stephan H. Bernhart, Helene Kretzmer, Anke K. Bergmann, Susanne Bens, Josef H?gel, Annika Müller, Billy Michael Jebaraj, Alexandra Schrader, Patricia Johansson, Dolors Costa, Matthias Schlesner, Jan Dürig, Marco Herling, Elias Campo, Stephan Stilgenbauer, Laura Wiehle and Reiner Siebert. 2022. T‐cell prolymphocytic leukemia is associated with deregulation of oncogenic microRNAs on transcriptional and epigenetic level. DOI: 10.1002/gcc.23034 |
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Diamanto Skopelitou, Aayushi Srivastava, Beiping Miao, Abhishek Kumar, Dagmara Dymerska, Nagarajan Paramasivam, Matthias Schlesner, Jan Lubinski, Kari Hemminki, Asta F?rsti and Obul Reddy Bandapalli. 2022. Whole exome sequencing identifies novel germline variants of SLC15A4 gene as potentially cancer predisposing in familial colorectal cancer. DOI: 10.1007/s00438-022-01896-0 |
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Beiping Miao, Diamanto Skopelitou, Aayushi Srivastava, Sara Giangiobbe, Dagmara Dymerska, Nagarajan Paramasivam, Abhishek Kumar, Magdalena Ku?wik, Wojciech Klu?niak, Katarzyna Paszkowska-Szczur, Matthias Schlesner, Jan Lubinski, Kari Hemminki, Asta F?rsti and Obul Reddy Bandapalli. 2022. Whole-exome sequencing identifies a novel germline variant in PTK7 gene in familial colorectal cancer. DOI: 10.3390/ijms23031295 |
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Dina ElHarouni, Yannick Berker, Heike Peterziel, Apurva Gopisetty, Laura Turunen, Sina Kreth, Sabine A. Stainczyk, Ina Oehme, Vilja Pieti?inen, Natalie J?ger, Olaf Witt, Matthias Schlesner and Sina Oppermann. 2022. iTReX: Interactive exploration of mono- and combination therapy dose response profiling data. DOI: 10.1016/j.phrs.2021.105996 |
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2021 |
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Diamanto Skopelitou, Beiping Miao, Aayushi Srivastava, Abhishek Kumar, Magdalena Ku?wik, Dagmara Dymerska, Nagarajan Paramasivam, Matthias Schlesner, Jan Lubiński, Kari Hemminki, Asta F?rsti and Obul Reddy Bandapalli. 2021. A novel low-risk germline variant in the SH2 domain of the SRC gene affects multiple pathways in familial colorectal cancer. DOI: 10.3390/jpm11040262 |
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Abhishek Kumar, Nagarajan Paramasivam, Obul Reddy Bandapalli, Matthias Schlesner, Tianhui Chen, Rolf Sijmons, Dagmara Dymerska, Katarzyna Golebiewska, Magdalena Kuswik, Jan Lubinski, Kari Hemminki and Asta F?rsti. 2021. A rare large duplication of MLH1 identified in Lynch syndrome. DOI: 10.1186/s13053-021-00167-0 |
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Elisa Espinet, Zuguang Gu, Charles D. Imbusch, Nathalia A. Giese, Magdalena Büscher, Mariam Safavi, Silke Weisenburger, Corinna Klein, Vanessa Vogel, Mattia Falcone, Jacob Insua-Rodríguez, Manuel Reitberger, Vera Thiel, Steffi O. Kossi, Alexander Muckenhuber, Karnjit Sarai, Alex Y. L. Lee, Elyne Backx, Soheila Zarei, Matthias M. Gaida, Manuel Rodríguez-Paredes, Elisa Donato, Hsi-Yu Yen, Roland Eils, Matthias Schlesner, Nicole Pfarr, Thilo Hackert, Christoph Plass, Benedikt Brors, Katja Steiger, Dieter Weichenhan, H. Efsun Arda, Ilse Rooman, Janel L. Kopp, Oliver Strobel, Wilko Weichert, Martin R. Sprick and Andreas Trumpp. 2021. Aggressive PDACs show hypomethylation of repetitive elements and the execution of an intrinsic IFN program linked to a ductal cell of origin. DOI: 10.1158/2159-8290.cd-20-1202 |
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Jeongbin Park, Wonyl Choi, Sebastian Tiesmeyer, Brian Long, Lars E. Borm, Emma Garren, Thuc Nghi Nguyen, Bosiljka Tasic, Simone Codeluppi, Tobias Graf, Matthias Schlesner, Oliver Stegle, Roland Eils and Naveed Ishaque. 2021. Cell segmentation-free inference of cell types from in situ transcriptomics data. DOI: 10.1038/s41467-021-23807-4 |
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Calogerina Catalano, Nagarajan Paramasivam, Joanna Blocka, Sara Giangiobbe, Stefanie Huhn, Matthias Schlesner, Niels Weinhold, Rolf Sijmons, Mirjam de Jong, Christian Langer, Klaus-Dieter Preuss, Bj?rn Nilsson, Brian Durie, Hartmut Goldschmidt, Obul Reddy Bandapalli, Kari Hemminki and Asta F?rsti. 2021. Characterization of rare germline variants in familial multiple myeloma. DOI: 10.1038/s41408-021-00422-6 |
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Stefan C. Dentro, Ignaty Leshchiner, Kerstin Haase, Maxime Tarabichi, Jeff Wintersinger, Amit G. Deshwar, Kaixian Yu, Yulia Rubanova, Geoff Macintyre, Jonas Demeulemeester, Ignacio Vázquez-García, Kortine Kleinheinz, Dimitri G. Livitz, Salem Malikic, Nilgun Donmez, Subhajit Sengupta, Pavana Anur, Clemency Jolly, Marek Cmero, Daniel Rosebrock, Steven E. Schumacher, Yu Fan, Matthew Fittall, Ruben M. Drews, Xiaotong Yao, Thomas B. K. Watkins, Juhee Lee, Matthias Schlesner, Hongtu Zhu, David J. Adams, Nicholas McGranahan, Charles Swanton, Gad Getz, Paul C. Boutros, Marcin Imielinski, Rameen Beroukhim, S. Cenk Sahinalp, Yuan Ji, Martin Peifer, Inigo Martincorena, Florian Markowetz, Ville Mustonen, Ke Yuan, Moritz Gerstung, Paul T. Spellman, Wenyi Wang, Quaid D. Morris, David C. Wedge and Peter Van Loo. 2021. Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes. DOI: 10.1016/j.cell.2021.03.009 |
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Emily P. Slater, Lisa M. Wilke, Lutz Benedikt B?hm, Konstantin Strauch, Manuel Lutz, Norman Gercke, Elvira Matth?i, Kari Hemminki, Asta F?rsti, Matthias Schlesner, Nagarajan Paramasivam and Detlef K. Bartsch. 2021. Combinations of low-frequency genetic variants might predispose to familial pancreatic cancer. DOI: 10.3390/jpm11070631 |
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Arlou Kristina Angeles, Petros Christopoulos, Zhao Yuan, Simone Bauer, Florian Janke, Simon John Ogrodnik, Martin Reck, Matthias Schlesner, Michael Meister, Marc A. Schneider, Steffen Dietz, Albrecht Stenzinger, Michael Thomas and Holger Sültmann. 2021. Early identification of disease progression in ALK-rearranged lung cancer using circulating tumor DNA analysis. DOI: 10.1038/s41698-021-00239-3 |
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Marina Scheller, Anne Kathrin Ludwig, Stefanie G?llner, Christian Rohde, Stephen Kr?mer, Sina St?ble, Maike Janssen, James-Arne Müller, Lixiazi He, Nicole B?umer, Christian Arnold, Joachim Ger?, Maximilian Sch?nung, Christian Thiede, Christian Niederwieser, Dietger Niederwieser, Hubert Serve, Wolfgang E. Berdel, Ulrich Thiem, Inga Hemmerling, Florian Leuschner, Christoph Plass, Matthias Schlesner, Judith Zaugg, Michael D. Milsom, Andreas Trumpp, Caroline Pabst, Daniel B. Lipka and Carsten Müller-Tidow. 2021. Hotspot DNMT3A mutations in clonal hematopoiesis and acute myeloid leukemia sensitize cells to azacytidine via viral mimicry response. DOI: 10.1038/s43018-021-00213-9 |
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Ana Maia, Zuguang Gu, André Koch, Mireia Berdiel‐Acer, Rainer Will, Matthias Schlesner and Stefan Wiemann. 2021. IFNβ1 secreted by breast cancer cells undergoing chemotherapy reprograms stromal fibroblasts to support tumour growth after treatment. DOI: 10.1002/1878-0261.12905 |
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Elmar Kirches, Felix Sahm, Andrey Korshunov, Christina Bluecher, Natalie Waldt, Siegfried Kropf, Daniel Schrimpf, Philipp Sievers, Damian Stichel, Ulrich Schüller, Jens Schittenhelm, Markus J. Riemenschneider, Matthias A. Karajannis, Arie Perry, Torsten Pietsch, Svenja Boekhoff, David Capper, Katja Beck, Nagarajan Paramasivam, Matthias Schlesner, Priscilla K. Brastianos, Hermann L. Müller, Stefan M. Pfister and Christian Mawrin. 2021. Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas. DOI: 10.1007/s00401-021-02351-x |
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Daniel Hübschmann, Kortine Kleinheinz, Rabea Wagener, Stephan H. Bernhart, Cristina López, Umut H. Toprak, Stephanie Sungalee, Naveed Ishaque, Helene Kretzmer, Markus Kreuz, Sebastian M. Waszak, Nagarajan Paramasivam, Ole Ammerpohl, Sietse M. Aukema, Renée Beekman, Anke K. Bergmann, Matthias Bieg, Hans Binder, Arndt Borkhardt, Christoph Borst, Benedikt Brors, Philipp Bruns, Enrique Carrillo de Santa Pau, Alexander Claviez, Gero Doose, Andrea Haake, Dennis Karsch, Siegfried Haas, Martin-Leo Hansmann, Jessica I. Hoell, Volker Hovestadt, Bingding Huang, Michael Hummel, Christina J?ger-Schmidt, Jules N. A. Kerssemakers, Jan O. Korbel, Dieter Kube, Chris Lawerenz, Dido Lenze, Joost H. A. Martens, German Ott, Bernhard Radlwimmer, Eva Reisinger, Julia Richter, Daniel Rico, Philip Rosenstiel, Andreas Rosenwald, Markus Schillhabel, Stephan Stilgenbauer, Peter F. Stadler, José I. Martín-Subero, Monika Szczepanowski, Gregor Warsow, Marc A. Weniger, Marc Zapatka, Alfonso Valencia, Hendrik G. Stunnenberg, Peter Lichter, Peter M?ller, Markus Loeffler, Roland Eils, Wolfram Klapper, Steve Hoffmann, Lorenz Trümper, Ralf Küppers, Matthias Schlesner and Reiner Siebert. 2021. Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas. DOI: 10.1038/s41375-021-01251-z |
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C. Blume, Helin Dogan, Lisa Schweizer, Wyatt Wick, Michael G. Weller, Martina Mann, Michel Kalamarides, A. von Deimling, Matthias Schlesner and Franziska Sahm. 2021. OS12.7. A characterization of intra-tumoral heterogeneity and differential immune activation during malignant progression of meningiomas on single cell level. DOI: 10.1093/neuonc/noab180.050 |
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Muhammad Aslam, Nirosiya Kandasamy, Anwar Ullah, Nagarajan Paramasivam, Mehmet Ali ?ztürk, Saima Naureen, Abida Arshad, Mazhar Badshah, Kafaitullah Khan, Muhammad Wajid, Rashda Abbasi, Muhammad Ilyas, Roland Eils, Matthias Schlesner, Rebecca C. Wade, Nafees Ahmad and Jakob von Engelhardt. 2021. Putative second hit rare genetic variants in families with seemingly GBA-associated Parkinson's disease. DOI: 10.1038/s41525-020-00163-8 |
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Mahak Singhal, Nicolas Gengenbacher, Ashik Ahmed Abdul Pari, Miki Kamiyama, Ling Hai, Bianca J. Kuhn, David M. Kallenberg, Shubhada R. Kulkarni, Carlotta Camilli, Stephanie F. Preu?, Barbara Leuchs, Carolin Mogler, Elisa Espinet, Eva Besemfelder, Danijela Heide, Mathias Heikenwalder, Martin R. Sprick, Andreas Trumpp, Jeroen Krijgsveld, Matthias Schlesner, Junhao Hu, Stephen E. Moss, John Greenwood and Hellmut G. Augustin. 2021. Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis. DOI: 10.1126/scitranslmed.abe6805 |
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Nicolas Gengenbacher, Mahak Singhal, Carolin Mogler, Ling Hai, Laura Milde, Ashik Ahmed Abdul Pari, Eva Besemfelder, Claudine Fricke, Daniel Baumann, Stephanie Gehrs, Jochen Utikal, Moritz Felcht, Junhao Hu, Matthias Schlesner, Rienk Offringa, Sudhakar R. Chintharlapalli and Hellmut G. Augustin. 2021. Timed Ang2-targeted therapy identifies the Angiopoietin–tie pathway as key regulator of fatal lymphogenous metastasis. DOI: 10.1158/2159-8290.cd-20-0122 |
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Ruifan Xie, Tobias Kessler, Julia Grosch, Ling Hai, Varun Venkataramani, Lulu Huang, Dirk C. Hoffmann, Gergely Solecki, Miriam Ratliff, Matthias Schlesner, Wolfgang Wick and Frank Winkler. 2021. Tumor cell network integration in glioma represents a stemness feature. DOI: 10.1093/neuonc/noaa275 |
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Diamanto Skopelitou, Beiping Miao, Aayushi Srivastava, Abhishek Kumar, Magdalena Ku?wik, Dagmara Dymerska, Nagarajan Paramasivam, Matthias Schlesner, Jan Lubinski, Kari Hemminki, Asta F?rsti and Obul Bandapalli. 2021. Whole exome sequencing identifies APCDD1 and HDAC5 genes as potentially cancer predisposing in familial colorectal cancer. DOI: 10.3390/ijms22041837 |
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Zuguang Gu, Matthias Schlesner and Daniel Hübschmann. 2021. cola: an R/Bioconductor package for consensus partitioning through a general framework. DOI: 10.1093/nar/gkaa1146 |
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2020 |
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Daniel Hübschmann, Lea Jopp‐Saile, Carolin Andresen, Stephen Kr?mer, Zuguang Gu, Christoph E. Heilig, Simon Kreutzfeldt, Veronica Teleanu, Stefan Fr?hling, Roland Eils and Matthias Schlesner. 2020. Analysis of mutational signatures with yet another package for signature analysis. DOI: 10.1002/gcc.22918 |
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Sergei Yakneen, S. M. Waszak, Michael Gertz, Jan O. Korbel and Matthias Schlesner. 2020. Butler enables rapid cloud-based analysis of thousands of human genomes. DOI: 10.1038/s41587-019-0360-3 |
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Guoqiao Zheng, Calogerina Catalano, Obul Reddy Bandapalli, Nagarajan Paramasivam, Subhayan Chattopadhyay, Matthias Schlesner, Rolf Sijmons, Akseli Hemminki, Dagmara Dymerska, Jan Lubinski, Kari Hemminki and Asta F?rsti. 2020. Cancer predisposition genes in cancer-free families. DOI: 10.3390/cancers12102770 |
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Rabea Wagener, Susanne Bens, Umut H. Toprak, Julian Seufert, Cristina López, Ingrid Scholz, Heidi Herbrueggen, Ilske Oschlies, Stephan Stilgenbauer, Matthias Schlesner, Wolfram Klapper, Birgit Burkhardt and Reiner Siebert. 2020. Cryptic insertion of MYC exons 2 and 3 into the immunoglobulin heavy chain locus detected by whole genome sequencing in a case of "MYC-negative" Burkitt lymphoma. DOI: 10.3324/haematol.2018.208140 |
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Tobias Roider, Julian Seufert, Alexey Uvarovskii, Felix Frauhammer, Marie Bordas, Nima Abedpour, Marta Stolarczyk, Jan-Philipp Mallm, Sophie A. Herbst, Peter-Martin Bruch, Hyatt Balke-Want, Michael Hundemer, Karsten Rippe, Benjamin Goeppert, Martina Seiffert, Benedikt Brors, Gunhild Mechtersheimer, Thorsten Zenz, Martin Peifer, Bj?rn Chapuy, Matthias Schlesner, Carsten Müller-Tidow, Stefan Fr?hling, Wolfgang Huber, Simon Anders and Sascha Dietrich. 2020. Dissecting intratumour heterogeneity of nodal B-cell lymphomas at the transcriptional, genetic and drug-response levels. DOI: 10.1038/s41556-020-0532-x |
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Scott Thiebes, Matthias Schlesner, Benedikt Brors and Ali Sunyaev. 2020. Distributed Ledger Technology in genomics: a call for Europe. DOI: 10.1038/s41431-019-0512-4 |
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Justin P. Whalley, Ivo Buchhalter, Esther Rheinbay, Keiran M. Raine, Miranda D. Stobbe, Kortine Kleinheinz, Johannes Werner, Sergi Beltran, Marta Gut, Daniel Hübschmann, Barbara Hutter, Dimitri Livitz, Marc D. Perry, Mara Rosenberg, Gordon Saksena, Jean-Rémi Trotta, Roland Eils, Daniela S. Gerhard, Peter J. Campbell, Matthias Schlesner and Ivo G. Gut. 2020. Framework for quality assessment of whole genome cancer sequences. DOI: 10.1038/s41467-020-18688-y |
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Dina Cramer, Johanna Mazur, Octavio Espinosa, Matthias Schlesner, Daniel Hübschmann, Roland Eils and Eike Staub. 2020. Genetic interactions and tissue specificity modulate the association of mutations with drug response. DOI: 10.1158/1535-7163.mct-19-0045 |
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Soo-Zin Kim-Wanner, Yassen Assenov, Mridul B. Nair, Dieter Weichenhan, Axel Benner, Natalia Becker, Katharina Landwehr, Ruprecht Kuner, Holger Sültmann, Manel Esteller, Ina Koch, Michael Lindner, Michael Meister, Michael Thomas, Matthias Bieg, Ursula Klingmüller, Matthias Schlesner, Arne Warth, Benedikt Brors, Erhard Seifried, Halvard B?nig, Christoph Plass, Angela Risch and Thomas Muley. 2020. Genome-wide DNA methylation profiling in early stage I lung adenocarcinoma reveals predictive aberrant methylation in the promoter region of the long noncoding RNA PLUT: an exploratory study. DOI: 10.1016/j.jtho.2020.03.023 |
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Lina Sieverling, Chen Hong, Sandra D. Koser, Philip Ginsbach, Kortine Kleinheinz, Barbara Hutter, Delia M. Braun, Isidro Cortés-Ciriano, Ruibin Xi, Rolf Kabbe, Peter J. Park, Roland Eils, Matthias Schlesner, Benedikt Brors, Karsten Rippe, David T. W. Jones and Lars Feuerbach. 2020. Genomic footprints of activated telomere maintenance mechanisms in cancer. DOI: 10.1038/s41467-019-13824-9 |
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Pavlo Lutsik, Annika Baude, Daniela Mancarella, Simin ?z, Alexander Kühn, Reka Toth, Joschka Hey, Umut H. Toprak, Jinyeong Lim, Viet Ha Nguyen, Chao Jiang, Anand Mayakonda, Mark Hartmann, Felix Rosemann, Kersten Breuer, Dominik Vonficht, Florian Grünschl?ger, Suman Lee, Maren Kirstin Schuhmacher, Denis Kusevic, Anna Jauch, Dieter Weichenhan, Jozef Zustin, Matthias Schlesner, Simon Haas, Joo Hyun Park, Yoon Jung Park, Udo Oppermann, Albert Jeltsch, Florian Haller, J?rg Fellenberg, Anders M. Lindroth and Christoph Plass. 2020. Globally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone. DOI: 10.1038/s41467-020-18955-y |
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Albrecht Stenzinger, Volker Endris, Jan Budczies, Sabine Merkelbach-Bruse, Daniel Kazdal, Wolfgang Dietmaier, Nicole Pfarr, Udo Siebolts, Michael Hummel, Sylvia Herold, Johanna Andreas, Martin Zoche, Lars T?gel, Eugen Rempel, J?rg Maas, Diana Merino, Mark Stewart, Karim Zaoui, Matthias Schlesner, Hanno Glimm, Stefan Fr?hling, Jeff Allen, David Horst, Gustavo Baretton, Claudia Wickenhauser, Markus Tiemann, Matthias Evert, Holger Moch, Thomas Kirchner, Reinhard Büttner, Peter Schirmacher, Andreas Jung, Florian Haller, Wilko Weichert and Manfred Dietel. 2020. Harmonization and standardization of panel-based tumor mutational burden measurement: real-world results and recommendations of?the?quality in pathology study. DOI: 10.1016/j.jtho.2020.01.023 |
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Daniela Choukair, Birgit Eberle, Philipp Vick, Pia Hermanns, Birgit Weiss, Nagarajan Paramasivam, Matthias Schlesner, Katharina Lornsen, Ralph Roeth, Carina Klutmann, Jennifer Kreis, Georg?F. Hoffmann, Joachim Pohlenz, Gudrun?A. Rappold and Markus Bettendorf. 2020. Identification of transient receptor potential channel 4-associated protein as a novel candidate gene causing congenital primary hypothyroidism. DOI: 10.1159/000507114 |
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Marek Cmero, Ke Yuan, Cheng Soon Ong, Jan Schr?der, Niall M. Corcoran, Tony Papenfuss, Christopher M. Hovens, Florian Markowetz, Geoff Macintyre and Matthias Schlesner. 2020. Inferring structural variant cancer cell fraction. DOI: 10.1038/s41467-020-14351-8 |
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Steffen Dietz, Petros Christopoulos, Zhao Yuan, Arlou Kristina Angeles, Lisa Gu, Anna-Lena Volckmar, Simon J. Ogrodnik, Florian Janke, Chiara Dalle Fratte, Tomasz Zemojtel, Marc A. Schneider, Daniel Kazdal, Volker Endris, Michael Meister, Thomas Muley, Erika Cecchin, Martin Reck, Matthias Schlesner, Michael Thomas, Albrecht Stenzinger and Holger Sültmann. 2020. Longitudinal therapy monitoring of ALK-positive lung cancer by combined copy number and targeted mutation profiling of cell-free DNA. DOI: 10.1016/j.ebiom.2020.103103 |
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Tobias Kessler, Anne Berberich, Belen Casalini, Katharina Drüschler, Hannah Ostermann, Andrea Dormann, Sandy Walter, Ling Hai, Matthias Schlesner, Christel Herold-Mende, Christine Jungk, Andreas Unterberg, Martin Bendszus, Katharina Sahm, Andreas von Deimling, Frank Winkler, Michael Platten, Wolfgang Wick, Felix Sahm and Antje Wick. 2020. Molecular profiling-based decision for targeted therapies in IDH wild-type glioblastoma. DOI: 10.1093/noajnl/vdz060 |
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Sarah Luiken, Angelika Fraas, Matthias Bieg, Raisatun Sugiyanto, Benjamin Goeppert, Stephan Singer, Carolin Ploeger, Gregor Warsow, Jens U. Marquardt, Carsten Sticht, Carolina De La Torre, Stefan Pusch, Arianeb Mehrabi, Norbert Gretz, Matthias Schlesner, Roland Eils, Peter Schirmacher, Thomas Longerich and Stephanie Roessler. 2020. NOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis. DOI: 10.1038/s41388-020-1198-3 |
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Ashwin Narayanan, Enrique Blanco-Carmona, Engin Demirdizen, Xueyuan Sun, Christel Herold-Mende, Matthias Schlesner and Sevin Turcan. 2020. Nuclei isolation from fresh frozen brain tumors for single-nucleus RNA-seq and ATAC-seq. DOI: 10.3791/61542 |
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Peter J. Campbell, Gad Getz, Jan O. Korbel, Joshua M. Stuart, Jennifer L. Jennings, Lincoln D. Stein and Matthias Schlesner. 2020. Pan-cancer analysis of whole genomes. DOI: 10.1038/s41586-020-1969-6 |
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Yulia Rubanova, Ruian Shi, Caitlin F. Harrigan, Roujia Li, Jeff Wintersinger, Nil Sahin, Amit Deshwar, Quaid Morris and Matthias Schlesner. 2020. Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig. DOI: 10.1038/s41467-020-14352-7 |
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Paurnima Patil, Agata Cieslak, Stephan H. Bernhart, Umut H. Toprak, Rabea Wagener, Cristina López, Laura Wiehle, Susanne Bens, Janine Altmüller, Marek Franitza, Ingrid Scholz, Sandrine Jayne, Matthew J. Ahearne, Annika Scheffold, Billy M. C. Jebaraj, Christof Schneider, Dolors Costa, Till Braun, Alexandra Schrader, Elias Campo, Martin J. S. Dyer, Peter Nürnberg, Jan Dürig, Patricia Johansson, Sebastian B?ttcher, Matthias Schlesner, Marco Herling, Stephan Stilgenbauer, Elizabeth Macintyre and Reiner Siebert. 2020. Reconstruction of rearranged T‐cell receptor loci by whole genome and transcriptome sequencing gives insights into the initial steps of T‐cell prolymphocytic leukemia. DOI: 10.1002/gcc.22821 |
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Matthew H. Bailey, William U. Meyerson, Lewis Jonathan Dursi, Liang-Bo Wang, Guanlan Dong, Wen-Wei Liang, Amila Weerasinghe, Shantao Li, Yize Li, Sean Kelso, Gordon Saksena, Kyle Ellrott, Michael C. Wendl, David A. Wheeler, Gad Getz, Jared T. Simpson, Mark B. Gerstein, Li Ding and Matthias Schlesner. 2020. Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. DOI: 10.1038/s41467-020-18151-y |
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Constance H. Li, Stephenie D. Prokopec, Ren X. Sun, Fouad Yousif, Nathaniel Schmitz, Paul C. Boutros and Matthias Schlesner. 2020. Sex differences in oncogenic mutational processes. DOI: 10.1038/s41467-020-17359-2 |
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Andres Quintero, Daniel Hübschmann, Nils Kurzawa, Sebastian Steinhauser, Philipp Rentzsch, Stephen Kr?mer, Carolin Andresen, Jeongbin Park, Roland Eils, Matthias Schlesner and Carl Herrmann. 2020. ShinyButchR: interactive NMF-based decomposition workflow of genome-scale datasets. DOI: 10.1093/biomethods/bpaa022 |
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Moritz Gerstung, Clemency Jolly, Ignaty Leshchiner, Stefan C. Dentro, Santiago Gonzalez, Daniel Rosebrock, Thomas J. Mitchell, Yulia Rubanova, Pavana Anur, Kaixian Yu, Maxime Tarabichi, Amit Deshwar, Jeff Wintersinger, Kortine Kleinheinz, Ignacio Vázquez-García, Kerstin Haase, Lara Jerman, Subhajit Sengupta, Geoff Macintyre, Salem Malikic, Nilgun Donmez, Dimitri G. Livitz, Marek Cmero, Jonas Demeulemeester, Steven Schumacher, Yu Fan, Xiaotong Yao, Juhee Lee, Matthias Schlesner, Paul C. Boutros, David D. Bowtell, Hongtu Zhu, Gad Getz, Marcin Imielinski, Rameen Beroukhim, S. Cenk Sahinalp, Yuan Ji, Martin Peifer, Florian Markowetz, Ville Mustonen, Ke Yuan, Wenyi Wang, Quaid D. Morris, Paul T. Spellman, David C. Wedge and Peter Van Loo. 2020. The evolutionary history of 2,658 cancers. DOI: 10.1038/s41586-019-1907-7 |
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Marc Zapatka, Ivan Borozan, Daniel S. Brewer, Murat Iskar, Adam Grundhoff, Malik Alawi, Nikita Desai, Holger Sültmann, Holger Moch, Colin S. Cooper, Roland Eils, Vincent Ferretti, Peter Lichter and Matthias Schlesner. 2020. The landscape of viral associations in human cancers. DOI: 10.1038/s41588-019-0558-9 |
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Philipp Sievers, Jason Chiang, Daniel Schrimpf, Damian Stichel, Nagarajan Paramasivam, Martin Sill, Tenzin Gayden, Belen Casalini, David E. Reuss, James Dalton, Kristian W. Pajtler, Daniel H?nggi, Christel Herold-Mende, Elisabeth Rushing, Andrey Korshunov, Christian Mawrin, Michael Weller, Matthias Schlesner, Wolfgang Wick, Nada Jabado, David T. W. Jones, Stefan M. Pfister, Andreas von Deimling, David W. Ellison and Felix Sahm. 2020. YAP1-fusions in pediatric NF2-wildtype meningioma. DOI: 10.1007/s00401-019-02095-9 |
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2019 |
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Stefan Gr?schel, Daniel Hübschmann, Francesco Raimondi, Peter Horak, Gregor Warsow, Martina Fr?hlich, Barbara Klink, Laura Gieldon, Barbara Hutter, Kortine Kleinheinz, David Bonekamp, Oliver Marschal, Priya Chudasama, Jagoda Mika, Marie Groth, Sebastian Uhrig, Stephen Kr?mer, Christoph Heining, Christoph E. Heilig, Daniela Richter, Eva Reisinger, Katrin Pfütze, Roland Eils, Stephan Wolf, Christof von Kalle, Christian Brandts, Claudia Scholl, Wilko Weichert, Stephan Richter, Sebastian Bauer, Roland Penzel, Evelin Schr?ck, Albrecht Stenzinger, Richard F. Schlenk, Benedikt Brors, Robert B. Russell, Hanno Glimm, Matthias Schlesner and Stefan Fr?hling. 2019. Defective homologous recombination DNA repair as therapeutic target in advanced chordoma. DOI: 10.1038/s41467-019-09633-9 |
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Daniel Hübschmann and Matthias Schlesner. 2019. Evaluation of whole genome sequencing data. DOI: 10.1007/978-1-4939-9151-8_15 |
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Verena K?rber, Jing Yang, Pankaj Barah, Yonghe Wu, Damian Stichel, Zuguang Gu, Michael Nai Chung Fletcher, David Jones, Bettina Hentschel, Katrin Lamszus, J?rg Christian Tonn, Gabriele Schackert, Michael Sabel, J?rg Felsberg, Angela Zacher, Kerstin Kaulich, Daniel Hübschmann, Christel Herold-Mende, Andreas von Deimling, Michael Weller, Bernhard Radlwimmer, Matthias Schlesner, Guido Reifenberger, Thomas H?fer and Peter Lichter. 2019. Evolutionary trajectories of IDHWT glioblastomas reveal a common path of early tumorigenesis instigated years ahead of initial diagnosis. DOI: 10.1016/j.ccell.2019.02.007 |
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Cristina López, Kortine Kleinheinz, Sietse M. Aukema, Marius Rohde, Stephan H. Bernhart, Daniel Hübschmann, Rabea Wagener, Umut H. Toprak, Francesco Raimondi, Markus Kreuz, Sebastian M. Waszak, Zhiqin Huang, Lina Sieverling, Nagarajan Paramasivam, Julian Seufert, Stephanie Sungalee, Robert B. Russell, Julia Bausinger, Helene Kretzmer, Ole Ammerpohl, Anke K. Bergmann, Hans Binder, Arndt Borkhardt, Benedikt Brors, Alexander Claviez, Gero Doose, Lars Feuerbach, Andrea Haake, Martin-Leo Hansmann, Jessica Hoell, Michael Hummel, Jan O. Korbel, Chris Lawerenz, Dido Lenze, Bernhard Radlwimmer, Julia Richter, Philip Rosenstiel, Andreas Rosenwald, Markus B. Schilhabel, Harald Stein, Stephan Stilgenbauer, Peter F. Stadler, Monika Szczepanowski, Marc A. Weniger, Marc Zapatka, Roland Eils, Peter Lichter, Markus Loeffler, Peter M?ller, Lorenz Trümper, Wolfram Klapper, Steve Hoffmann, Ralf Küppers, Birgit Burkhardt, Matthias Schlesner and Reiner Siebert. 2019. Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma. DOI: 10.1038/s41467-019-08578-3 |
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Nagarajan Paramasivam, Daniel Hübschmann, Umut H Toprak, Naveed Ishaque, Marian Neidert, Daniel Schrimpf, Damian Stichel, David Reuss, Philipp Sievers, Annekathrin Reinhardt, Annika K. Wefers, David T. W. Jones, Zuguang Gu, Johannes Werner, Sebastian Uhrig, Hans-Georg Wirsching, Matthias Schick, Melanie Bewerunge-Hudler, Katja Beck, Stephanie Brehmer, Steffi Urbschat, Marcel Seiz-Rosenhagen, Daniel H?nggi, Christel Herold-Mende, Ralf Ketter, Roland Eils, Zvi Ram, Stefan M. Pfister, Wolfgang Wick, Michael Weller, Rachel Grossmann, Andreas von Deimling, Matthias Schlesner and Felix Sahm. 2019. Mutational patterns and regulatory networks in epigenetic subgroups of meningioma. DOI: 10.1007/s00401-019-02008-w |
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Stephan M. Tirier, Jeongbin Park, Friedrich Preu?er, Lisa Amrhein, Zuguang Gu, Simon Steiger, Jan-Philipp Mallm, Teresa Krieger, Marcel Waschow, Bj?rn Eismann, Marta Gut, Ivo G. Gut, Karsten Rippe, Matthias Schlesner, Fabian Theis, Christiane Fuchs, Claudia R. Ball, Hanno Glimm, Roland Eils and Christian Conrad. 2019. Pheno-seq: linking visual features and gene expression in 3D cell culture systems. DOI: 10.1038/s41598-019-48771-4 |
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Peter Horak, Joachim Weischenfeldt, Gunhild von Amsberg, Burkhard Beyer, Andreas Schütte, Sebastian Uhrig, Laura Gieldon, Barbara Klink, Lars Feuerbach, Daniel Hübschmann, Simon Kreutzfeldt, Christoph Heining, Sebastian Maier, Barbara Hutter, Roland Penzel, Matthias Schlesner, Roland Eils, Guido Sauter, Albrecht Stenzinger, Benedikt Brors, Evelin Schr?ck, Hanno Glimm, Stefan Fr?hling and Thorsten Schlomm. 2019. Response to olaparib in a PALB2 germline mutated prostate cancer and genetic events associated with resistance. DOI: 10.1101/mcs.a003657 |
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Muhammad Aslam, Anwar Ullah, Nagarajan Paramasivam, Nirosiya Kandasamy, Saima Naureen, Mazhar Badshah, Kafaitullah Khan, Muhammad Wajid, Rashda Abbasi, Roland Eils, Marc A. Brockmann, Matthias Schlesner, Nafees Ahmad and Jakob von Engelhardt. 2019. Segregation and potential functional impact of a rare stop-gain PABPC4L variant in familial atypical Parkinsonism. DOI: 10.1038/s41598-019-50102-6 |
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Steffen Dietz, Petros Christopoulos, Lisa Gu, Anna-Lena Volckmar, Volker Endris, Zhao Yuan, Simon J. Ogrodnik, Tomasz Zemojtel, Claus-Peter Heussel, Marc A. Schneider, Michael Meister, Thomas Muley, Martin Reck, Matthias Schlesner, Michael Thomas, Albrecht Stenzinger and Holger Sültmann. 2019. Serial liquid biopsies for detection of treatment failure and profiling of resistance mechanisms in KLC1–ALK-rearranged lung cancer. DOI: 10.1101/mcs.a004630 |
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Karthik Shivaji Paithankar, Mathias Enderle, David C. Wirthensohn, Arthur Miller, Matthias Schlesner, Friedhelm Pfeiffer, Alexander Rittner, Martin Grininger and Dieter Oesterhelt. 2019. Structure of the archaeal chemotaxis protein CheY in a domain-swapped dimeric conformation. DOI: 10.1107/s2053230x19010896 |
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Rabea Wagener, Julian Seufert, Francesco Raimondi, Susanne Bens, Kortine Kleinheinz, Inga Nagel, Janine Altmüller, Holger Thiele, Daniel Hübschmann, Christian W. Kohler, Peter Nürnberg, Rex Au-Yeung, Birgit Burkhardt, Heike Horn, Lorenzo Leoncini, Elaine S. Jaffe, German Ott, Grzegorz Rymkiewicz, Matthias Schlesner, Robert B. Russell, Wolfram Klapper and Reiner Siebert. 2019. The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma. DOI: 10.1182/blood-2018-07-864025 |
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2018 |
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Tobias Marschall, Manja Marz, Thomas Abeel, Louis Dijkstra, Bas E. Dutilh, Ali Ghaffaari, Paul Kersey, Wigard P. Kloosterman, Veli M?kinen, Adam M. Novak, Benedict Paten, David Porubsky, Eric Rivals, Can Alkan, Jasmijn A. Baaijens, Paul I. W. De Bakker, Valentina Boeva, Raoul J. P. Bonnal, Francesca Chiaromonte, Rayan Chikhi, Francesca D. Ciccarelli, Robin Cijvat, Erwin Datema, Cornelia M. Van Duijn, Evan E. Eichler, Corinna Ernst, Eleazar Eskin, Erik Garrison, Mohammed El-Kebir, Gunnar W. Klau, Jan O. Korbel, Eric-Wubbo Lameijer, Benjamin Langmead, Marcel Martin, Paul 伟德国际_伟德国际1946$娱乐app游戏vedev, John C. Mu, Pieter Neerincx, Klaasjan Ouwens, Pierre Peterlongo, Nadia Pisanti, Sven Rahmann, Ben Raphael, Knut Reinert, Dick de Ridder, Jeroen de Ridder, Matthias Schlesner, Ole Schulz-Trieglaff, Ashley D. Sanders, Siavash Sheikhizadeh, Carl Shneider, Sandra Smit, Daniel Valenzuela, Jiayin Wang, Lodewyk Wessels, Ying Zhang, Victor Guryev, Fabio Vandin, Kai Ye and Alexander Sch?nhuth. 2018. Computational pan-genomics: status, promises and challenges. DOI: 10.1093/bib/bbw089 |
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Bianca Dimitrov, Nastassja Himmelreich, Agnes L. Hipgrave Ederveen, Christian Lüchtenborg, Jürgen G. Okun, Maximilian Breuer, Anna-Marlen Hutter, Matthias Carl, Luca Guglielmi, Andrea Hellwig, Kai Christian Thiemann, Markus Jost, Verena Peters, Christian Staufner, Georg F. Hoffmann, Annette Hackenberg, Nagarajan Paramasivam, Stefan Wiemann, Roland Eils, Matthias Schlesner, Sabine Strahl, Britta Brügger, Manfred Wuhrer, G. Christoph Korenke and Christian Thiel. 2018. Cutis laxa, exocrine pancreatic insufficiency and altered cellular metabolomics as additional symptoms in a new patient with ATP6AP1-CDG. DOI: 10.1016/j.ymgme.2018.01.008 |
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Zuguang Gu, Roland Eils, Matthias Schlesner and Naveed Ishaque. 2018. EnrichedHeatmap: an R/Bioconductor package for comprehensive visualization of genomic signal associations. DOI: 10.1186/s12864-018-4625-x |
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Abhishek Kumar, Obul Reddy Bandapalli, Nagarajan Paramasivam, Sara Giangiobbe, Chiara Diquigiovanni, Elena Bonora, Roland Eils, Matthias Schlesner, Kari Hemminki and Asta F?rsti. 2018. Familial cancer variant prioritization pipeline version 2 (FCVPPv2) applied to a papillary thyroid cancer family. DOI: 10.1038/s41598-018-29952-z |
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Gregor Warsow, Daniel Hübschmann, Kortine Kleinheinz, Cathleen Nientiedt, Martina Heller, Laura Van Coile, Yanis Tolstov, Lukas Trennheuser, Kathrin Wieczorek, Carine Pecqueux, Claudia Gasch, Timur Kuru, Joanne Nyarangi-Dix, Gencay Hatiboglu, Dogu Teber, Sven Perner, Albrecht Stenzinger, Wilfried Roth, Boris Hadaschik, Sascha Pahernik, Dirk J?ger, Carsten Grüllich, Anette Duensing, Roland Eils, Matthias Schlesner, Holger Sültmann, Markus Hohenfellner and Stefan Duensing. 2018. Genomic features of renal cell carcinoma with venous tumor thrombus. DOI: 10.1038/s41598-018-25544-z |
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Rabea Wagener, Cristina López, Kortine Kleinheinz, Julia Bausinger, Sietse M. Aukema, Inga Nagel, Umut H. Toprak, Julian Seufert, Janine Altmüller, Holger Thiele, Christof Schneider, Julia Kolarova, Jeongbin Park, Daniel Hübschmann, Eva M. Murga Penas, Hans G. Drexler, Andishe Attarbaschi, Randi Hovland, Eigil Kjeldsen, Michael Kneba, Udo Kontny, Laurence de Leval, Peter Nürnberg, Ilske Oschlies, David Oscier, Brigitte Schlegelberger, Stephan Stilgenbauer, Wilhelm W?ssmann, Matthias Schlesner, Birgit Burkhardt, Wolfram Klapper, Elaine S. Jaffe, Ralf Küppers and Reiner Siebert. 2018. IG-MYC+ neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomas. DOI: 10.1182/blood-2018-03-842088 |
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Nagarajan Paramasivam, Martin Granzow, Christina Evers, Katrin Hinderhofer, Stefan Wiemann, Claus R. Bartram, Roland Eils and Matthias Schlesner. 2018. Identification and prioritization of causal variants of human genetic disorders from exome or whole genome sequencing data. DOI: 10.21926/obm.genet.1802017 |
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Franziska Simm, Anne Griesbeck, Daniela Choukair, Birgit Wei?, Nagarajan Paramasivam, Jürgen Klammt, Matthias Schlesner, Stefan Wiemann, Cristina Martinez, Georg F Hoffmann, Roland W Pf?ffle, Markus Bettendorf and Gudrun A Rappold. 2018. Identification of SLC20A1 and SLC15A4 among other genes as potential risk factors for combined pituitary hormone deficiency. DOI: 10.1038/gim.2017.165 |
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Priya Chudasama, Sadaf S. Mughal, Mathijs A. Sanders, Daniel Hübschmann, Inn Chung, Katharina I. Deeg, Siao-Han Wong, Sophie Rabe, Mario Hlevnjak, Marc Zapatka, Aurélie Ernst, Kortine Kleinheinz, Matthias Schlesner, Lina Sieverling, Barbara Klink, Evelin Schr?ck, Remco M. Hoogenboezem, Bernd Kasper, Christoph E. Heilig, Gerlinde Egerer, Stephan Wolf, Christof von Kalle, Roland Eils, Albrecht Stenzinger, Wilko Weichert, Hanno Glimm, Stefan Gr?schel, Hans-Georg Kopp, Georg Omlor, Burkhard Lehner, Sebastian Bauer, Simon Schimmack, Alexis Ulrich, Gunhild Mechtersheimer, Karsten Rippe, Benedikt Brors, Barbara Hutter, Marcus Renner, Peter Hohenberger, Claudia Scholl and Stefan Fr?hling. 2018. Integrative genomic and transcriptomic analysis of leiomyosarcoma. DOI: 10.1038/s41467-017-02602-0 |
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Clarissa Gerhauser, Francesco Favero, Thomas Risch, Ronald Simon, Lars Feuerbach, Yassen Assenov, Doreen Heckmann, Nikos Sidiropoulos, Sebastian M. Waszak, Daniel Hübschmann, Alfonso Urbanucci, Etsehiwot G. Girma, Vladimir Kuryshev, Leszek J. Klimczak, Natalie Saini, Adrian M. Stütz, Dieter Weichenhan, Lisa-Marie B?ttcher, Reka Toth, Josephine D. Hendriksen, Christina Koop, Pavlo Lutsik, S?ren Matzk, Hans-J?rg Warnatz, Vyacheslav Amstislavskiy, Clarissa Feuerstein, Benjamin Raeder, Olga Bogatyrova, Eva-Maria Schmitz, Claudia Hube-Magg, Martina Kluth, Hartwig Huland, Markus Graefen, Chris Lawerenz, Gervaise H. Henry, Takafumi N. Yamaguchi, Alicia Malewska, Jan Meiners, Daniela Schilling, Eva Reisinger, Roland Eils, Matthias Schlesner, Douglas W. Strand, Robert G. Bristow, Paul C. Boutros, Christof von Kalle, Dmitry Gordenin, Holger Sültmann, Benedikt Brors, Guido Sauter, Christoph Plass, Marie-Laure Yaspo, Jan O. Korbel, Thorsten Schlomm and Joachim Weischenfeldt. 2018. Molecular evolution of early-onset prostate cancer identifies molecular risk markers and clinical trajectories. DOI: 10.1016/j.ccell.2018.10.016 |
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Christoph Heining, Peter Horak, Sebastian Uhrig, Paula L. Codo, Barbara Klink, Barbara Hutter, Martina Fr?hlich, David Bonekamp, Daniela Richter, Katja Steiger, Roland Penzel, Volker Endris, Karl Roland Ehrenberg, Stephanie Frank, Kortine Kleinheinz, Umut H. Toprak, Matthias Schlesner, Ranadip Mandal, Lothar Schulz, Helmut Lambertz, Sebastian Fetscher, Michael Bitzer, Nisar P. Malek, Marius Horger, Nathalia A. Giese, Oliver Strobel, Thilo Hackert, Christoph Springfeld, Lars Feuerbach, Frank Bergmann, Evelin Schr?ck, Christof von Kalle, Wilko Weichert, Claudia Scholl, Claudia R. Ball, Albrecht Stenzinger, Benedikt Brors, Stefan Fr?hling and Hanno Glimm. 2018. NRG1 fusions in KRAS wild-type pancreatic cancer. DOI: 10.1158/2159-8290.cd-18-0036 |
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Maxime Tarabichi, I?igo Martincorena, Moritz Gerstung, Armand M. Leroi, Florian Markowetz, Paul T. Spellman, Quaid D. Morris, Ole Christian Lingj?rde, David C. Wedge, Peter Van Loo and Matthias Schlesner. 2018. Neutral tumor evolution? [Letter]. DOI: 10.1038/s41588-018-0258-x |
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Sang-Tae Kim, Jeongbin Park, Daesik Kim, Kyoungmi Kim, Sangsu Bae, Matthias Schlesner and Jin-Soo Kim. 2018. Response to "Unexpected mutations after CRISPR–Cas9 editing in vivo". DOI: 10.1038/nmeth.4554 |
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Susanne N. Gr?bner, Barbara C. Worst, Joachim Weischenfeldt, Ivo Buchhalter, Kortine Kleinheinz, Vasilisa A. Rudneva, Pascal-David Johann, Gnana Prakash Balasubramanian, Maia Segura-Wang, Sebastian Brabetz, Sebastian Bender, Barbara Hutter, Dominik Sturm, Elke Pfaff, Daniel Hübschmann, Gideon Zipprich, Michael Heinold, Jürgen Eils, Christian Lawerenz, Serap Erkek, Sander Lambo, Sebastian Waszak, Claudia Blattmann, Arndt Borkhardt, Michaela Kuhlen, Angelika Eggert, Simone Fulda, Manfred Gessler, Jenny Wegert, Roland Kappler, Daniel Baumhoer, Stefan Burdach, Renate Kirschner-Schwabe, Udo Kontny, Andreas E. Kulozik, Dietmar Lohmann, Simone Hettmer, Cornelia Eckert, Stefan Bielack, Michaela Nathrath, Charlotte Niemeyer, Günther H. Richter, Johannes Schulte, Reiner Siebert, Frank Westermann, Jan J. Molenaar, Gilles Vassal, Hendrik Witt, Birgit Burkhardt, Christian P. Kratz, Olaf Witt, Cornelis M. van Tilburg, Christof M. Kramm, Gudrun Fleischhack, Uta Dirksen, Stefan Rutkowski, Michael C. Frühwald, Katja von Hoff, Stephan Wolf, Thomas Klingebiel, Ewa Koscielniak, Pablo Landgraf, Jan Koster, Adam C. Resnick, Jinghui Zhang, Yanling Liu, Xin Zhou, Angela J. Waanders, Danny A. Zwijnenburg, Pichai Raman, Benedikt Brors, Ursula D. Weber, Paul A. Northcott, Kristian W. Pajtler, Marcel Kool, Rosario M. Piro, Jan O. Korbel, Matthias Schlesner, Roland Eils, David T. W. Jones, Peter Lichter, Lukas Chavez, Marc Zapatka and Stefan M. Pfister. 2018. The landscape of genomic alterations across childhood cancers. DOI: 10.1038/nature25480 |
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Katharina Schlereth, Dieter Weichenhan, Tobias Bauer, Tina Heumann, Evangelia Giannakouri, Daniel Lipka, Samira Jaeger, Matthias Schlesner, Patrick Aloy, Roland Eils, Christoph Plass and Hellmut G Augustin. 2018. The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium. DOI: 10.7554/elife.34423 |
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Naveed Ishaque, Mohammed L. Abba, Christine Hauser, Nitin Patil, Nagarajan Paramasivam, Daniel Huebschmann, J?rg Hendrik Leupold, Gnana Prakash Balasubramanian, Kortine Kleinheinz, Umut H. Toprak, Barbara Hutter, Axel Benner, Anna Shavinskaya, Chan Zhou, Zuguang Gu, Jules Kerssemakers, Alexander Marx, Marcin Moniuszko, Miroslaw Kozlowski, Joanna Reszec, Jacek Niklinski, Jürgen Eils, Matthias Schlesner, Roland Eils, Benedikt Brors and Heike Allgayer. 2018. Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer. DOI: 10.1038/s41467-018-07041-z |
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Obul Reddy Bandapalli, Nagarajan Paramasivam, Sara Giangiobbe, Abhishek Kumar, Wolfgang Benisch, Andreas Engert, Mathias Witzens‐Harig, Matthias Schlesner, Kari Hemminki and Asta F?rsti. 2018. Whole genome sequencing reveals DICER1 as a candidate predisposing gene in familial Hodgkin lymphoma [Letter]. DOI: 10.1002/ijc.31576 |
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2017 |
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Rafiullah Rafiullah, Alyssa B. Long, Anna A. Ivanova, Hazrat Ali, Simone Berkel, Ghulam Mustafa, Nagarajan Paramasivam, Matthias Schlesner, Stefan Wiemann, Rebecca C. Wade, Eugen Bolthauser, Martin Blum, Richard A. Kahn, Tamara Caspary and Gudrun A. Rappold. 2017. A novel homozygous ARL13B variant in patients with Joubert syndrome impairs its guanine nucleotide-exchange factor activity. DOI: 10.1038/s41431-017-0031-0 |
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Muhammad Aslam, Anwarullah Anwarullah, Nagarajan Paramasivam, Rashda Abbasi, Kafaitullah Khan, Aneesa Sultan, Matthias Schlesner, Jakob von Engelhardt and Nafees Ahmad. 2017. A report of whole-genome sequencing in neurologic Wilson's disease [Letter]. DOI: 10.4103/neuroindia.ni_1274_16 |
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Kortine Kleinheinz, Isabell Bludau, Daniel Hübschmann, Michael Heinold, Philip Kensche, Zuguang Gu, Cristina López, Michael Hummel, Wolfram Klapper, Peter M?ller, Inga Vater, Rabea Wagener, Benedikt Brors, Reiner Siebert, Roland Eils and Matthias Schlesner. 2017. ACEseq – allele specific copy number estimation from whole genome sequencing. DOI: 10.1101/210807 |
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Nicola Dikow, Martin Granzow, Luitgard M. Graul-Neumann, Stephanie Karch, Katrin Hinderhofer, Nagarajan Paramasivam, Laura-Jane Behl, Lilian Kaufmann, Christine Fischer, Christina Evers, Matthias Schlesner, Roland Eils, Guntram Borck, Christiane Zweier, Claus R. Bartram, John C. Carey and Ute Moog. 2017. DDX3X mutations in two girls with a phenotype overlapping Toriello-Carey syndrome. DOI: 10.1002/ajmg.a.38164 |
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Daniel Hüebschmann, Nils Kurzawa, Sebastian Steinhauser, Philipp Rentzsch, Stephen Kr?mer, Carolin Andresen, Jeongbin Park, Roland Eils, Matthias Schlesner and Carl Herrmann. 2017. Deciphering programs of transcriptional regulation by combined deconvolution of multiple omics layers. DOI: 10.1101/199547 |
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A Zamò, J Pischimarov, Matthias Schlesner, P Rosenstiel, R Bomben, H Horn, T Grieb, T Nedeva, C López, A Haake, J Richter, L Trümper, C Lawerenz, W Klapper, P M?ller, M Hummel, D Lenze, M Szczepanowski, L Flossbach, M Schreder, V Gattei, G Ott, R Siebert, A Rosenwald and E Leich. 2017. Differences between BCL2-break positive and negative follicular lymphoma unraveled by whole-exome sequencing. DOI: 10.1038/leu.2017.270 |
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Klara M. Giessler, Kortine Kleinheinz, Daniel Huebschmann, Gnana Prakash Balasubramanian, Taronish D. Dubash, Sebastian M. Dieter, Christine Siegl, Friederike Herbst, Sarah Weber, Christopher M. Hoffmann, Raffaele Fronza, Ivo Buchhalter, Nagarajan Paramasivam, Roland Eils, Manfred Schmidt, Christof von Kalle, Martin Schneider, Alexis Ulrich, Claudia Scholl, Stefan Fr?hling, Wilko Weichert, Benedikt Brors, Matthias Schlesner, Claudia R. Ball and Hanno Glimm. 2017. Genetic subclone architecture of tumor clone-initiating cells in colorectal cancer. DOI: 10.1084/jem.20162017 |
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Christina Evers, Christian Staufner, Martin Granzow, Nagarajan Paramasivam, Katrin Hinderhofer, Lilian Kaufmann, Christine Fischer, Christian Thiel, Thomas Opladen, Urania Kotzaeridou, Stefan Wiemann, Matthias Schlesner, Roland Eils, Stefan K?lker, Claus R. Bartram, Georg F. Hoffmann and Ute Moog. 2017. Impact of clinical exomes in neurodevelopmental and neurometabolic disorders. DOI: 10.1016/j.ymgme.2017.06.014 |
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Felix Sahm, Umut H. Toprak, Daniel Hübschmann, Kortine Kleinheinz, Ivo Buchhalter, Martin Sill, Damian Stichel, Matthias Schick, Melanie Bewerunge-Hudler, Daniel Schrimpf, Gelareh Zadeh, Ken Aldape, Christel Herold-Mende, Katja Beck, Ori Staszewski, Marco Prinz, Carmit Ben Harosh, Roland Eils, Dominik Sturm, David T. W. Jones, Stefan M. Pfister, Werner Paulus, Zvi Ram, Matthias Schlesner, Rachel Grossman and Andreas von Deimling. 2017. Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature. DOI: 10.1007/s00401-017-1715-9 |
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S.M. Dieter, C. Heining, A. Agaimy, D. Huebschmann, D. Bonekamp, B. Hutter, K.R. Ehrenberg, M. Fr?hlich, Matthias Schlesner, C. Scholl, H.-P. Schlemmer, S. Wolf, A. Mavratzas, C.S. Jung, S. Gr?schel, Christof von Kalle, R. Eils, B. Brors, R. Penzel, M. Kriegsmann, D.E. Reuss, P. Schirmacher, A. Stenzinger, P.A. Federspil, W. Weichert, H. Glimm and S. Fr?hling. 2017. Mutant KIT as imatinib-sensitive target in metastatic sinonasal carcinoma. DOI: 10.1093/annonc/mdw446 |
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Steffen Dietz, Holger Sültmann, YueJun Du, Eva Reisinger, Anja Lisa Riediger, Anna-Lena Volckmar, Albrecht Stenzinger, Matthias Schlesner, Dirk J?ger, Markus Hohenfellner, Stefan Duensing, Carsten Grüllich and Sascha Pahernik. 2017. Patient-specific molecular alterations are associated with metastatic clear cell renal cell cancer progressing under tyrosine kinase inhibitor therapy. DOI: 10.18632/oncotarget.18200 |
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Peter Horak, Barbara Klink, Christoph Heining, Stefan Gr?schel, Barbara Hutter, Martina Fr?hlich, Sebastian Uhrig, Daniel Hübschmann, Matthias Schlesner, Roland Eils, Daniela Richter, Katrin Pfütze, Christina Ge?rg, Bettina Mei?burger, Stephan Wolf, Angela Schulz, Roland Penzel, Esther Herpel, Martina Kirchner, Amelie Lier, Volker Endris, Stephan Singer, Peter Schirmacher, Wilko Weichert, Albrecht Stenzinger, Richard F. Schlenk, Evelin Schr?ck, Benedikt Brors, Christof von Kalle, Hanno Glimm and Stefan Fr?hling. 2017. Precision oncology based on omics data: the NCT Heidelberg experience. DOI: 10.1002/ijc.30828 |
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Daniel B. Lipka, Tania Witte, Reka Toth, Jing Yang, Manuel Wiesenfarth, Peter N?llke, Alexandra Fischer, David Brocks, Zuguang Gu, Jeongbin Park, Brigitte Strahm, Marcin Wlodarski, Ayami Yoshimi, Rainer Claus, Michael Lübbert, Hauke Busch, Melanie Boerries, Mark Hartmann, Maximilian Sch?nung, Umut Kilik, Jens Langstein, Justyna A. Wierzbinska, Caroline Pabst, Swati Garg, Albert Catalá, Barbara De Moerloose, Michael Dworzak, Henrik Hasle, Franco Locatelli, Riccardo Masetti, Markus Schmugge, Owen Smith, Jan Stary, Marek Ussowicz, Marry M. van den Heuvel-Eibrink, Yassen Assenov, Matthias Schlesner, Charlotte Niemeyer, Christian Flotho and Christoph Plass. 2017. RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia. DOI: 10.1038/s41467-017-02177-w |
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Abbas Agaimy, Matthias Bieg, Michael Michal, Helene Geddert, Bruno M?rkl, Jan Seitz, Evgeny A. Moskalev, Matthias Schlesner, Markus Metzler, Arndt Hartmann, Stefan Wiemann, Michal Michal, Thomas Mentzel and Florian Haller. 2017. Recurrent somatic PDGFRB mutations in sporadic infantile/solitary adult myofibromas but not in angioleiomyomas and myopericytomas. DOI: 10.1097/pas.0000000000000752 |
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Julia Jabs, Franziska M. Zickgraf, Jeongbin Park, Steve Wagner, Xiaoqi Jiang, Katharina Jechow, Kortine Kleinheinz, Umut H. Toprak, Marc A. Schneider, Michael Meister, Saskia Spaich, Marc Sütterlin, Matthias Schlesner, Andreas Trumpp, Martin Sprick, Roland Eils and Christian Conrad. 2017. Screening drug effects in patient‐derived cancer cells links organoid responses to genome alterations. DOI: 10.15252/msb.20177697 |
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Paul A. Northcott, Ivo Buchhalter, A. Sorana Morrissy, Volker Hovestadt, Joachim Weischenfeldt, Tobias Ehrenberger, Susanne Gr?bner, Maia Segura-Wang, Thomas Zichner, Vasilisa A. Rudneva, Hans-J?rg Warnatz, Nikos Sidiropoulos, Aaron H. Phillips, Steven Schumacher, Kortine Kleinheinz, Sebastian M. Waszak, Serap Erkek, David T. W. Jones, Barbara C. Worst, Marcel Kool, Marc Zapatka, Natalie J?ger, Lukas Chavez, Barbara Hutter, Matthias Bieg, Nagarajan Paramasivam, Michael Heinold, Zuguang Gu, Naveed Ishaque, Christina J?ger-Schmidt, Charles D. Imbusch, Alke Jugold, Daniel Hübschmann, Thomas Risch, Vyacheslav Amstislavskiy, Francisco German Rodriguez Gonzalez, Ursula D. Weber, Stephan Wolf, Giles W. Robinson, Xin Zhou, Gang Wu, David Finkelstein, Yanling Liu, Florence M. G. Cavalli, Betty Luu, Vijay Ramaswamy, Xiaochong Wu, Jan Koster, Marina Ryzhova, Yoon-Jae Cho, Scott L. Pomeroy, Christel Herold-Mende, Martin Schuhmann, Martin Ebinger, Linda M. Liau, Jaume Mora, Roger E. McLendon, Nada Jabado, Toshihiro Kumabe, Eric Chuah, Yussanne Ma, Richard A. Moore, Andrew J. Mungall, Karen L. Mungall, Nina Thiessen, Kane Tse, Tina Wong, Steven J. M. Jones, Olaf Witt, Till Milde, Andreas von Deimling, David Capper, Andrey Korshunov, Marie-Laure Yaspo, Richard Kriwacki, Amar Gajjar, Jinghui Zhang, Rameen Beroukhim, Ernest Fraenkel, Jan O. Korbel, Benedikt Brors, Matthias Schlesner, Roland Eils, Marco A. Marra, Stefan M. Pfister, Michael D. Taylor and Peter Lichter. 2017. The whole-genome landscape of medulloblastoma subtypes. DOI: 10.1038/nature22973 |
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2016 |
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Zuguang Gu, Roland Eils and Matthias Schlesner. 2016. "gtrellis": an R/Bioconductor package for making genome-level Trellis graphics. DOI: 10.1186/s12859-016-1051-4 |
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Kebria Hezaveh, Andreas Kloetgen, Stephan H. Bernhart, Kunal Das Mahapatra, Dido Lenze, Julia Richter, Andrea Haake, Anke K. Bergmann, Benedikt Brors, Birgit Burkhardt, Alexander Claviez, Hans G. Drexler, Roland Eils, Siegfried Haas, Steve Hoffmann, Dennis Karsch, Wolfram Klapper, Kortine Kleinheinz, Jan Korbel, Helene Kretzmer, Markus Kreuz, Ralf Küppers, Chris Lawerenz, Ellen Leich, Markus Loeffler, Luisa Mantovani-Loeffler, Cristina López, Alice C. McHardy, Peter M?ller, Marius Rohde, Philip Rosenstiel, Andreas Rosenwald, Markus Schilhabel, Matthias Schlesner, Ingrid Scholz, Peter F. Stadler, Stephan Stilgenbauer, Stéphanie Sungalee, Monika Szczepanowski, Lorenz Trümper, Marc A. Weniger, Reiner Siebert, Arndt Borkhardt, Michael Hummel and Jessica I. Hoell. 2016. Alterations of microRNA and microRNA-regulated messenger RNA expression in germinal center B-cell lymphomas determined by integrative sequencing analysis. DOI: 10.3324/haematol.2016.143891 |
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Gero Knittel, Paul Liedgens, Darya Korovkina, Jens M. Seeger, Yussor Al-Baldawi, Mona Al-Maarri, Christian Fritz, Katerina Vlantis, Svetlana Bezhanova, Andreas H. Scheel, Olaf-Oliver Wolz, Maurice Reimann, Peter M?ller, Cristina López, Matthias Schlesner, Philipp Lohneis, Alexander N. R. Weber, Lorenz Trümper, Louis M. Staudt, Monika Ortmann, Manolis Pasparakis, Reiner Siebert, Clemens A. Schmitt, Andreas R. Klatt, F. Thomas Wunderlich, Stephan C. Sch?fer, Thorsten Persigehl, Manuel Montesinos-Rongen, Margarete Odenthal, Reinhard Büttner, Lukas P. Frenzel, Hamid Kashkar and H. Christian Reinhardt. 2016. B-cell–specific conditional expression of Myd88p.L252P leads to the development of diffuse large B-cell lymphoma in mice. DOI: 10.1182/blood-2015-11-684183 |
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Elisa M. Noll, Christian Eisen, Albrecht Stenzinger, Elisa Espinet, Alexander Muckenhuber, Corinna Klein, Vanessa Vogel, Bernd Klaus, Wiebke Nadler, Christoph R?sli, Christian Lutz, Michael Kulke, Jan Engelhardt, Franziska M. Zickgraf, Octavio Espinosa, Matthias Schlesner, Xiaoqi Jiang, Annette Kopp-Schneider, Peter Neuhaus, Marcus Bahra, Bruno V. Sinn, Roland Eils, Nathalia A. Giese, Thilo Hackert, Oliver Strobel, Jens Werner, Markus W. Büchler, Wilko Weichert, Andreas Trumpp and Martin R. Sprick. 2016. CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma. DOI: 10.1038/nm.4038 |
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Zuguang Gu, Roland Eils and Matthias Schlesner. 2016. Complex heatmaps reveal patterns and correlations in multidimensional genomic data. DOI: 10.1093/bioinformatics/btw313 |
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Tobias Bauer, Saskia Trump, Naveed Ishaque, Loreen Thürmann, Lei Gu, Mario Bauer, Matthias Bieg, Zuguang Gu, Dieter Weichenhan, Jan‐Philipp Mallm, Stefan R?der, Gunda Herberth, Eiko Takada, Oliver Mücke, Marcus Winter, Kristin M. Junge, Konrad Grützmann, Ulrike Rolle‐Kampczyk, Qi Wang, Christian Lawerenz, Michael Borte, Tobias Polte, Matthias Schlesner, Michaela Schanne, Stefan Wiemann, Christina Ge?rg, Hendrik G. Stunnenberg, Christoph Plass, Karsten Rippe, Junichiro Mizuguchi, Carl Herrmann, Roland Eils and Irina Lehmann. 2016. Environment‐induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children. DOI: 10.15252/msb.20156520 |
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Christina Evers, Lilian Kaufmann, Angelika Seitz, Nagarajan Paramasivam, Martin Granzow, Stephanie Karch, Christine Fischer, Katrin Hinderhofer, Georg Gdynia, Michael Els?sser, Stefan Pinkert, Matthias Schlesner, Claus R. Bartram and Ute Moog. 2016. Exome sequencing reveals a novel CWF19L1 mutation associated with intellectual disability and cerebellar atrophy. DOI: 10.1002/ajmg.a.37632 |
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Zuguang Gu, Roland Eils and Matthias Schlesner. 2016. HilbertCurve: an R/Bioconductor package for high-resolution visualization of genomic data. DOI: 10.1093/bioinformatics/btw161 |
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Rafiullah Rafiullah, Muhammad Aslamkhan, Nagarajan Paramasivam, Christian Thiel, Ghulam Mustafa, Stefan Wiemann, Matthias Schlesner, Rebecca C Wade, Gudrun A Rappold and Simone Berkel. 2016. Homozygous missense mutation in the LMAN2L gene segregates with intellectual disability in a large consanguineous Pakistani family. DOI: 10.1136/jmedgenet-2015-103179 |
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Zeynep Ko?alo?lu, Inka Z?rnig, Niels Halama, Iris Kaiser, Ivo Buchhalter, Niels Grabe, Roland Eils, Matthias Schlesner, Andrea Califano and Dirk J?ger. 2016. Identification of immunotherapeutic targets by genomic profiling of rectal NET metastases. DOI: 10.1080/2162402x.2016.1213931 |
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M. Szczepanowski, N. Masque-Soler, Matthias Schlesner, A. Haake, J. Richter, R. Wagener, B. Burkhardt, M. Kreuz, R. Siebert and W. Klapper. 2016. Immunohistochemical detection of inhibitor of DNA binding 3 mutational variants in mature aggressive B-cell lymphoma. DOI: 10.3324/haematol.2015.138701 |
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Anton Shostak, Bianca Ruppert, Nati Ha, Philipp Bruns, Umut H. Toprak, Roland Eils, Matthias Schlesner, Axel Diernfellner and Michael Brunner. 2016. MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation. DOI: 10.1038/ncomms11807 |
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Dominik Sturm, Brent?A. Orr, Umut?H. Toprak, Volker Hovestadt, David?T.W. Jones, David Capper, Martin Sill, Ivo Buchhalter, Paul?A. Northcott, Irina Leis, Marina Ryzhova, Christian Koelsche, Elke Pfaff, Sariah?J. Allen, Gnanaprakash Balasubramanian, Barbara?C. Worst, Kristian?W. Pajtler, Sebastian Brabetz, Pascal-David Johann, Felix Sahm, Jüri Reimand, Alan Mackay, Diana?M. Carvalho, Marc Remke, Joanna?J. Phillips, Arie Perry, Cynthia Cowdrey, Rachid Drissi, Maryam Fouladi, Felice Giangaspero, Maria ?astowska, Wies?awa Grajkowska, Wolfram Scheurlen, Torsten Pietsch, Christian Hagel, Johannes Gojo, Daniela L?tsch, Walter Berger, Irene Slavc, Christine Haberler, Anne Jouvet, Stefan Holm, Silvia Hofer, Marco Prinz, Catherine Keohane, Iris Fried, Christian Mawrin, David Scheie, Bret?C. Mobley, Matthew?J. Schniederjan, Mariarita Santi, Anna?M. Buccoliero, Sonika Dahiya, Christof?M. Kramm, André?O. von?Bueren, Katja von?Hoff, Stefan Rutkowski, Christel Herold-Mende, Michael C. Frühwald, Till Milde, Martin Hasselblatt, Pieter Wesseling, Jochen R??ler, Ulrich Schüller, Martin Ebinger, Jens Schittenhelm, Stephan Frank, Rainer Grobholz, Istvan Vajtai, Volkmar Hans, Reinhard Schneppenheim, Karel Zitterbart, V.?Peter Collins, Eleonora Aronica, Pascale Varlet, Stephanie Puget, Christelle Dufour, Jacques Grill, Dominique Figarella-Branger, Marietta Wolter, Martin?U. Schuhmann, Tarek Shalaby, Michael Grotzer, Timothy van?Meter, Camelia-Maria Monoranu, J?rg Felsberg, Guido Reifenberger, Matija Snuderl, Lynn?Ann Forrester, Jan Koster, Rogier Versteeg, Richard Volckmann, Peter van?Sluis, Stephan Wolf, Tom Mikkelsen, Amar Gajjar, Kenneth Aldape, Andrew?S. Moore, Michael?D. Taylor, Chris Jones, Nada Jabado, Matthias?A. Karajannis, Roland Eils, Matthias Schlesner, Peter Lichter, Andreas von Deimling, Stefan?M. Pfister, David?W. Ellison, Andrey Korshunov and Marcel Kool. 2016. New brain tumor entities emerge from molecular classification of CNS-PNETs. DOI: 10.1016/j.cell.2016.01.015 |
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Barbara C. Worst, Cornelis M. van Tilburg, Gnana Prakash Balasubramanian, Petra Fiesel, Ruth Witt, Angelika Freitag, Miream Boudalil, Christopher Previti, Stephan Wolf, Sabine Schmidt, Sasithorn Chotewutmontri, Melanie Bewerunge-Hudler, Matthias Schick, Matthias Schlesner, Barbara Hutter, Lenka Taylor, Tobias Borst, Christian Sutter, Claus R. Bartram, Till Milde, Elke Pfaff, Andreas E. Kulozik, Arend von Stackelberg, Roland Meisel, Arndt Borkhardt, Dirk Reinhardt, Jan-Henning Klusmann, Gudrun Fleischhack, Stephan Tippelt, Uta Dirksen, Heribert Jürgens, Christof M. Kramm, Andre O. von Bueren, Frank Westermann, Matthias Fischer, Birgit Burkhardt, Wilhelm W??mann, Michaela Nathrath, Stefan S. Bielack, Michael C. Frühwald, Simone Fulda, Thomas Klingebiel, Ewa Koscielniak, Matthias Schwab, Roman Tremmel, Pablo Hernáiz Driever, Johannes H. Schulte, Benedikt Brors, Andreas von Deimling, Peter Lichter, Angelika Eggert, David Capper, Stefan M. Pfister, David T. W. Jones and Olaf Witt. 2016. Next-generation personalised medicine for high-risk paediatric cancer patients – the INFORM pilot study. DOI: 10.1016/j.ejca.2016.06.009 |
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Florian Haller, Jasmin Knopf, Anne Ackermann, Matthias Bieg, Kortine Kleinheinz, Matthias Schlesner, Evgeny A Moskalev, Rainer Will, Ali Abdel Satir, Ibtihalat E Abdelmagid, Johannes Giedl, Roman Carbon, Oliver Rompel, Arndt Hartmann, Stefan Wiemann, Markus Metzler and Abbas Agaimy. 2016. Paediatric and adult soft tissue sarcomas with NTRK1 gene fusions: a subset of spindle cell sarcomas unified by a prominent myopericytic/haemangiopericytic pattern. DOI: 10.1002/path.4701 |
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Asta F?rsti, Abhishek Kumar, Nagarajan Paramasivam, Matthias Schlesner, Calogerina Catalano, Dagmara Dymerska, Jan Lubinski, Roland Eils and Kari Hemminki. 2016. Pedigree based DNA sequencing pipeline for germline genomes of cancer families. DOI: 10.1186/s13053-016-0058-1 |
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Saskia Trump, Matthias Bieg, Zuguang Gu, Loreen Thürmann, Tobias Bauer, Mario Bauer, Naveed Ishaque, Stefan R?der, Lei Gu, Gunda Herberth, Christian Lawerenz, Michael Borte, Matthias Schlesner, Christoph Plass, Nicolle Diessl, Markus Eszlinger, Oliver Mücke, Horst-Dietrich Elvers, Dirk K. Wissenbach, Martin von Bergen, Carl Herrmann, Dieter Weichenhan, Rosalind J. Wright, Irina Lehmann and Roland Eils. 2016. Prenatal maternal stress and wheeze in children: novel insights into epigenetic regulation. DOI: 10.1038/srep28616 |
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Rouven Hoefflin, Bernd Lahrmann, Gregor Warsow, Daniel Hübschmann, Cathleen Spath, Britta Walter, Xin Chen, Luisa Hofer, Stephan Macher-Goeppinger, Yanis Tolstov, Nina Korzeniewski, Anette Duensing, Carsten Grüllich, Dirk J?ger, Sven Perner, Gita Sch?nberg, Joanne Nyarangi-Dix, Sanjay Isaac, Gencay Hatiboglu, Dogu Teber, Boris Hadaschik, Sascha Pahernik, Wilfried Roth, Roland Eils, Matthias Schlesner, Holger Sültmann, Markus Hohenfellner, Niels Grabe and Stefan Duensing. 2016. Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity. DOI: 10.1038/ncomms11845 |
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Elena Senís, Stefan Mockenhaupt, Daniel Rupp, Tobias Bauer, Nagarajan Paramasivam, Bettina Knapp, Jan Gronych, Stefanie Grosse, Marc P. Windisch, Florian Schmidt, Fabian J. Theis, Roland Eils, Peter Lichter, Matthias Schlesner, Ralf Bartenschlager and Dirk Grimm. 2016. TALEN/CRISPR-mediated engineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus. DOI: 10.1093/nar/gkw805 |
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Matthias Schlesner. 2016. ?bersicht: Chancen und Herausforderungen von Big Data in der Onkologie. DOI: 10.1055/s-0042-109379 |
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2015 |
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Tyler S. Alioto, Ivo Buchhalter, Sophia Derdak, Barbara Hutter, Matthew D. Eldridge, Eivind Hovig, Lawrence E. Heisler, Timothy A. Beck, Jared T. Simpson, Laurie Tonon, Anne-Sophie Sertier, Ann-Marie Patch, Natalie J?ger, Philip Ginsbach, Ruben Drews, Nagarajan Paramasivam, Rolf Kabbe, Sasithorn Chotewutmontri, Nicolle Diessl, Christopher Previti, Sabine Schmidt, Benedikt Brors, Lars Feuerbach, Michael Heinold, Susanne Gr?bner, Andrey Korshunov, Patrick S. Tarpey, Adam P. Butler, Jonathan Hinton, David Jones, Andrew Menzies, Keiran Raine, Rebecca Shepherd, Lucy Stebbings, Jon W. Teague, Paolo Ribeca, Francesc Castro Giner, Sergi Beltran, Emanuele Raineri, Marc Dabad, Simon C. Heath, Marta Gut, Robert E. Denroche, Nicholas J. Harding, Takafumi N. Yamaguchi, Akihiro Fujimoto, Hidewaki Nakagawa, Víctor Quesada, Rafael Valdés-Mas, Sigve Nakken, Daniel Vodák, Lawrence Bower, Andrew G. Lynch, Charlotte L. Anderson, Nicola Waddell, John V. Pearson, Sean M. Grimmond, Myron Peto, Paul Spellman, Minghui He, Cyriac Kandoth, Semin Lee, John Zhang, Louis Létourneau, Singer Ma, Sahil Seth, David Torrents, Liu Xi, David A. Wheeler, Carlos López-Otín, Elías Campo, Peter J. Campbell, Paul C. Boutros, Xose S. Puente, Daniela S. Gerhard, Stefan M. Pfister, John D. McPherson, Thomas J. Hudson, Matthias Schlesner, Peter Lichter, Roland Eils, David T. W. Jones and Ivo G. Gut. 2015. A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing. DOI: 10.1038/ncomms10001 |
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R. Wagener, L. B. Alexandrov, M. Montesinos-Rongen, Matthias Schlesner, A. Haake, H. G. Drexler, J. Richter, G. R. Bignell, U. McDermott and R. Siebert. 2015. Analysis of mutational signatures in exomes from B-cell lymphoma cell lines suggest APOBEC3 family members to be involved in the pathogenesis of primary effusion lymphoma. DOI: 10.1038/leu.2015.22 |
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Helene Kretzmer, Stephan H. Bernhart, Wei Wang, Andrea Haake, Marc A. Weniger, Anke K. Bergmann, Matthew J. Betts, Enrique Carrillo-de-Santa-Pau, Gero Doose, Jana Gutwein, Julia Richter, Volker Hovestadt, Bingding Huang, Daniel Rico, Frank Jühling, Julia Kolarova, Qianhao Lu, Christian Otto, Rabea Wagener, Judith Arnolds, Birgit Burkhardt, Alexander Claviez, Hans G. Drexler, Sonja Eberth, Roland Eils, Paul Flicek, Siegfried Haas, Michael Hummel, Dennis Karsch, Hinrik H. D. Kerstens, Wolfram Klapper, Markus Kreuz, Chris Lawerenz, Dido Lenze, Markus Loeffler, Cristina López, Roderick A. F. MacLeod, Joost H. A. Martens, Marta Kulis, José Ignacio Martín-Subero, Peter M?ller, Inga Nagel, Simone Picelli, Inga Vater, Marius Rohde, Philip Rosenstiel, Maciej Rosolowski, Robert B. Russell, Markus Schilhabel, Matthias Schlesner, Peter F. Stadler, Monika Szczepanowski, Lorenz Trümper, Hendrik G. Stunnenberg, Ralf Küppers, Ole Ammerpohl, Peter Lichter, Reiner Siebert, Steve Hoffmann and Bernhard Radlwimmer. 2015. DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control. DOI: 10.1038/ng.3413 |
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Matthias Schlesner and Roland Eils. 2015. Hypermutation takes the driver's seat. DOI: 10.1186/s13073-015-0159-x |
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M. Granzow, N. Paramasivam, K. Hinderhofer, C. Fischer, S. Chotewutmontri, L. Kaufmann, C. Evers, U. Kotzaeridou, K. Rohrschneider, Matthias Schlesner, M. Sturm, S. Pinkert, R. Eils, C. R. Bartram, P. Bauer and U. Moog. 2015. Loss of function of PGAP1 as a cause of severe encephalopathy identified by whole exome sequencing: lessons of the bioinformatics pipeline. DOI: 10.1016/j.mcp.2015.05.012 |
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Gero Doose, Andrea Haake, Stephan H. Bernhart, Cristina López, Sujitha Duggimpudi, Franziska Wojciech, Anke K. Bergmann, Arndt Borkhardt, Birgit Burkhardt, Alexander Claviez, Lora Dimitrova, Siegfried Haas, Jessica I. Hoell, Michael Hummel, Dennis Karsch, Wolfram Klapper, Karsten Kleo, Helene Kretzmer, Markus Kreuz, Ralf Küppers, Chris Lawerenz, Dido Lenze, Markus Loeffler, Luisa Mantovani-L?ffler, Peter M?ller, German Ott, Julia Richter, Marius Rohde, Philip Rosenstiel, Andreas Rosenwald, Markus Schilhabel, Markus Schneider, Ingrid Scholz, Stephan Stilgenbauer, Hendrik G. Stunnenberg, Monika Szczepanowski, Lorenz Trümper, Marc A. Weniger, Steve Hoffmann, Reiner Siebert, Ingram Iaccarino and Matthias Schlesner. 2015. MINCR is a MYC-induced lncRNA able to modulate MYC's transcriptional network in Burkitt lymphoma cells. DOI: 10.1073/pnas.1505753112 |
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Christina Evers, Nagarajan Paramasivam, Katrin Hinderhofer, Christine Fischer, Martin Granzow, Annette Schmidt-Bacher, Roland Eils, Herbert Steinbeisser, Matthias Schlesner and Ute Moog. 2015. SIPA1L3 identified by linkage analysis and whole-exome sequencing as a novel gene for autosomal recessive congenital cataract. DOI: 10.1038/ejhg.2015.46 |
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Rabea Wagener, Sietse M. Aukema, Matthias Schlesner, Andrea Haake, Birgit Burkhardt, Alexander Claviez, Hans G. Drexler, Michael Hummel, Markus Kreuz, Markus Loeffler, Maciej Rosolowski, Cristina López, Peter M?ller, Julia Richter, Marius Rohde, Matthew J. Betts, Robert B. Russell, Stephan H. Bernhart, Steve Hoffmann, Philip Rosenstiel, Markus Schilhabel, Monika Szczepanowski, Lorenz Trümper, Wolfram Klapper and Reiner Siebert. 2015. The PCBP1 gene encoding poly(rc) binding protein i is recurrently mutated in Burkitt lymphoma. DOI: 10.1002/gcc.22268 |
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I. Vater, M. Montesinos-Rongen, Matthias Schlesner, A. Haake, F. Purschke, R. Sprute, N. Mettenmeyer, I. Nazzal, I. Nagel, J. Gutwein, J. Richter, I. Buchhalter, R. B. Russell, O. D. Wiestler, R. Eils, M. Deckert and R. Siebert. 2015. The mutational pattern of primary lymphoma of the central nervous system determined by whole-exome sequencing. DOI: 10.1038/leu.2014.264 |
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2014 |
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Zuguang Gu, Lei Gu, Roland Eils, Matthias Schlesner and Benedikt Brors. 2014. "Circlize" implements and enhances circular visualization in R. DOI: 10.1093/bioinformatics/btu393 |
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Itziar Salaverria, Idoia Martin-Guerrero, Rabea Wagener, Markus Kreuz, Christian W. Kohler, Julia Richter, Barbara Pienkowska-Grela, Patrick Adam, Birgit Burkhardt, Alexander Claviez, Christine Damm-Welk, Hans G. Drexler, Michael Hummel, Elaine S. Jaffe, Ralf Küppers, Christine Lefebvre, Jasmin Lisfeld, Markus L?ffler, Roderick A. F. Macleod, Inga Nagel, Ilske Oschlies, Maciej Rosolowski, Robert B. Russell, Grzegorz Rymkiewicz, Detlev Schindler, Matthias Schlesner, René Scholtysik, Carsten Schwaenen, Rainer Spang, Monika Szczepanowski, Lorenz Trümper, Inga Vater, Swen Wessendorf, Wolfram Klapper and Reiner Siebert. 2014. A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma. DOI: 10.1182/blood-2013-06-507996 |
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Matthew J. Betts, Qianhao Lu, YingYing Jiang, Armin Drusko, Oliver Wichmann, Mathias Utz, Ilse A. Valtierra-Gutiérrez, Matthias Schlesner, Natalie Jaeger, David T. Jones, Stefan Pfister, Peter Lichter, Roland Eils, Reiner Siebert, Peer Bork, Gordana Apic, Anne-Claude Gavin and Robert B. Russell. 2014. Mechismo: predicting the mechanistic impact of mutations and modifications on molecular interactions. DOI: 10.1093/nar/gku1094 |
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Marius Rohde, Julia Richter, Matthias Schlesner, Matthew J. Betts, Alexander Claviez, Bettina R. Bonn, Martin Zimmermann, Christine Damm-Welk, Robert B. Russell, Arndt Borkhardt, Roland Eils, Jessica I. Hoell, Monika Szczepanowski, Ilske Oschlies, Wolfram Klapper, Birgit Burkhardt and Reiner Siebert. 2014. Recurrent RHOA mutations in pediatric Burkitt lymphoma treated according to the NHL-BFM protocols. DOI: 10.1002/gcc.22202 |
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2013 |
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Natalie J?ger, Matthias Schlesner, David?T. W. Jones, Simon Raffel, Jan-Philipp Mallm, Kristin?M. Junge, Dieter Weichenhan, Tobias Bauer, Naveed Ishaque, Marcel Kool, Paul?A. Northcott, Andrey Korshunov, Ruben?M. Drews, Jan Koster, Rogier Versteeg, Julia Richter, Michael Hummel, Stephen?C. Mack, Michael?D. Taylor, Hendrik Witt, Benedict Swartman, Dietrich Schulte-Bockholt, Marc Sultan, Marie-Laure Yaspo, Hans Lehrach, Barbara Hutter, Benedikt Brors, Stephan Wolf, Christoph Plass, Reiner Siebert, Andreas Trumpp, Karsten Rippe, Irina Lehmann, Peter Lichter, Stefan?M. Pfister and Roland Eils. 2013. Hypermutation of the inactive X chromosome is a frequent event in cancer. DOI: 10.1016/j.cell.2013.09.042 |
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Ralf Wagner, Gülsah Gabriel, Matthias Schlesner, Nina Alex, Astrid Herwig, Ortrud Werner and Hans-Dieter Klenk. 2013. Protease activation mutants elicit protective immunity against highly pathogenic avian influenza viruses of subtype H7 in chickens and mice. DOI: 10.1038/emi2013.7 |
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David T. W. Jones, Barbara Hutter, Natalie J?ger, Andrey Korshunov, Marcel Kool, Hans-J?rg Warnatz, Thomas Zichner, Sally R. Lambert, Marina Ryzhova, Dong Anh Khuong Quang, Adam M. Fontebasso, Adrian M. Stütz, Sonja Hutter, Marc Zuckermann, Dominik Sturm, Jan Gronych, B?rbel Lasitschka, Sabine Schmidt, Huriye ?eker-Cin, Hendrik Witt, Marc Sultan, Meryem Ralser, Paul A. Northcott, Volker Hovestadt, Sebastian Bender, Elke Pfaff, Sebastian Stark, Damien Faury, Jeremy Schwartzentruber, Jacek Majewski, Ursula D. Weber, Marc Zapatka, Benjamin Raeder, Matthias Schlesner, Catherine L. Worth, Cynthia C. Bartholomae, Christof von Kalle, Charles D. Imbusch, Sylwester Radomski, Chris Lawerenz, Peter van Sluis, Jan Koster, Richard Volckmann, Rogier Versteeg, Hans Lehrach, Camelia Monoranu, Beate Winkler, Andreas Unterberg, Christel Herold-Mende, Till Milde, Andreas E. Kulozik, Martin Ebinger, Martin U. Schuhmann, Yoon-Jae Cho, Scott L. Pomeroy, Andreas von Deimling, Olaf Witt, Michael D. Taylor, Stephan Wolf, Matthias A. Karajannis, Charles G. Eberhart, Wolfram Scheurlen, Martin Hasselblatt, Keith L. Ligon, Mark W. Kieran, Jan O. Korbel, Marie-Laure Yaspo, Benedikt Brors, J?rg Felsberg, Guido Reifenberger, V. Peter Collins, Nada Jabado, Roland Eils and Peter Lichter. 2013. Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. DOI: 10.1038/ng.2682 |
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Ludmil B. Alexandrov, Serena Nik-Zainal, David C. Wedge, Samuel A. J. R. Aparicio, Sam Behjati, Andrew V. Biankin, Graham R. Bignell, Niccolò Bolli, Ake Borg, Anne-Lise B?rresen-Dale, Sandrine Boyault, Birgit Burkhardt, Adam P. Butler, Carlos Caldas, Helen R. Davies, Christine Desmedt, Roland Eils, Jórunn Erla Eyfj?rd, John A. Foekens, Mel Greaves, Fumie Hosoda, Barbara Hutter, Tomislav Ilicic, Sandrine Imbeaud, Marcin Imielinski, Natalie J?ger, David T. W. Jones, David Jones, Stian Knappskog, Marcel Kool, Sunil R. Lakhani, Carlos López-Otín, Sancha Martin, Nikhil C. Munshi, Hiromi Nakamura, Paul A. Northcott, Marina Pajic, Elli Papaemmanuil, Angelo Paradiso, John V. Pearson, Xose S. Puente, Keiran Raine, Manasa Ramakrishna, Andrea L. Richardson, Julia Richter, Philip Rosenstiel, Matthias Schlesner, Ton N. Schumacher, Paul N. Span, Jon W. Teague, Yasushi Totoki, Andrew N. J. Tutt, Rafael Valdés-Mas, Marit M. van Buuren, Laura van ’t Veer, Anne Vincent-Salomon, Nicola Waddell, Lucy R. Yates, Jessica Zucman-Rossi, P. Andrew Futreal, Ultan McDermott, Peter Lichter, Matthew Meyerson, Sean M. Grimmond, Reiner Siebert, Elías Campo, Tatsuhiro Shibata, Stefan M. Pfister, Peter J. Campbell and Michael R. Stratton. 2013. Signatures of mutational processes in human cancer. DOI: 10.1038/nature12477 |
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2012 |
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Claudia Otto, Maciej Giefing, Anne Massow, Inga Vater, Stefan Gesk, Matthias Schlesner, Julia Richter, Wolfram Klapper, Martin-Leo Hansmann, Reiner Siebert and Ralf Küppers. 2012. Genetic lesions of the TRAF3 and MAP3K14 genes in classical Hodgkin lymphoma. DOI: 10.1111/j.1365-2141.2012.09113.x |
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Julia Richter, Matthias Schlesner, Steve Hoffmann, Ellen Leich, Birgit Burkhardt, Maciej Rosolowski, Ole Ammerpohl, Rabea Wagener, Stephan Bernhart, Dido Lenze, Monika Szczepanowski, Maren Paulsen, Simone Lipinski, Robert Russell, Sabine Adam-Klages, Gordana Apic, Alexander Claviez, Dirk Hasenclever, Volker Hovestadt, Nadine Hornig, Jan Korbel, Dieter Kube, David Langenberger, Chris Lawerenz, Jasmin Lisfeld, Katharina Meyer, Simone Picelli, Jordan Pischimarov, Bernhard Radlwimmer, Tobias Rausch, Marius Rohde, Markus Schilhabel, René Scholtysik, Rainer Spang, Heiko Trautmann, Thorsten Zenz, Arndt Borkhardt, Hans Drexler, Peter M?ller, Roderick MacLeod, Christiane Pott, Stefan Schreiber, Lorenz Trümper, Markus Loeffler, Peter Stadler, Peter Lichter, Roland Eils, Ralf Küppers, Michael Hummel, Wolfram Klapper, Philip Rosenstiel, Andreas Rosenwald, Benedikt Brors and Reiner Siebert. 2012. Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing. DOI: 10.1038/ng.2469 |
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Matthias Schlesner, Arthur Miller, Hüseyin Besir, Michalis Aivaliotis, Judith Streif, Beatrix Scheffer, Frank Siedler and Dieter Oesterhelt. 2012. The protein interaction network of a taxis signal transduction system in a halophilic archaeon. DOI: 10.1186/1471-2180-12-272 |
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2009 |
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Matthias Schlesner, Arthur Miller, Stefan Streif, Wilfried F. Staudinger, Judith Müller, Beatrix Scheffer, Frank Siedler and Dieter Oesterhelt. 2009. Identification of archaea-specific chemotaxis proteins which interact with the flagellar apparatus. DOI: 10.1186/1471-2180-9-56 |
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2004 |
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Bjorn Titz, Matthias Schlesner and Peter Uetz. 2004. What do we learn from high-throughput protein interaction data?. DOI: 10.1586/14789450.1.1.111 |