AG 1 Koch
Neurobiologie umweltbedingter Stoffwechselerkrankungen
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Unser Hauptinteresse ist die Erforschung der zentralnerv?sen Regulation des Essverhaltens und der Energiehom?ostase. In den meisten modernen Industriegesellschaften bietet sich dem überwiegenden Anteil der Bev?lkerung eine adipogene Umwelt, also Lebensbedingungen, die krankhafte Fettleibigkeit (Adipositas) f?rdern und schlie?lich lebensbedrohliche Folgeerkrankungen wie Diabetes, Krebs, Herzinfarkt und Schlaganfall bei den Betroffenen begünstigen. Zudem erh?ht Adipositas die Wahrscheinlichkeit für schwere Covid-19 Krankheitsverl?ufe und gilt als ein Risikofaktor für neurologische Erkrankungen.
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In diesem Zusammenhang fokussiert sich die AG 1 mit der Adipositas auf eine ern?hrungsbedingte, systemische metabolische Erkrankung. Die übergeordnete Fragestellung in diesem Zusammenhang lautet, wie Essgewohnheiten, Di?ten und natürliche Nahrungsbestandteile die Funktion unseres Gehirns und somit unser Verhalten und unsere Gesundheit beeinflussen.
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Zudem untersuchen wir die physiologische und pathologische Relevanz von Gewebsmakrophagen für die strukturelle und funktionelle Plastizit?t definierter Gehirnregionen. Wir m?chten verstehen, wie sich Ern?hrung und andere Umweltfaktoren auf die Arbeitsweise der Mikroglia in definierten ZNS-Regionen auswirken.
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Fokus I:
Lipiderge Neurotransmitter in neuralen und neuroendokrinen Schaltkreisen ( DFG-GEPRIS)
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Fokus II:
Metabolismus- und umweltabh?ngige Dynamik intrazellul?rer Organellen in neuralen und neuroendokrinen Schaltkreisen
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Fokus III:
Mikroglia-abh?ngiges Remodeling im Hypothalamus
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Fokus IV:
Charakterisierung von Makrophagen in zirkumventrikul?ren Organen
Kooperationen
Prof. Dr. Jae Geun Kim, Incheon Universit?s, Südkorea
PD Dr. Martin Krüger, Universit?t Leipzig
Dr. Luis Varela, Basque Science System, Bilbao, Spanien
Prof. Dr. Tamas Horvath, Yale 伟德国际_伟德国际1946$娱乐app游戏ical School, New Haven, CT, USA
Forschungsf?rderung
Forschungsgro?ger?te: Konfokales Mikroskop, ITM-01
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SFB 1052: Mechanismen der Adipositas, Teilprojekt A07
Artikel
Publikationen
2023
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2022
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2019
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2018
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2017
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2016
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2015
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2014
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2013
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2012
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2011
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2010
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2009
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2008
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2007
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2006
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2003
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2002
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2001
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2023 |
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Steingruber Laura, Krabichler Florian, Franzmeier Sophie, Wu Wei, Schlegel Jürgen, Koch Marco.
ALDH1A1 and ALDH1A3 paralogues of aldehyde dehydrogenase 1 control myogenic differentiation of skeletal muscle satellite cells by retinoic acid-dependent and -independent mechanisms.
Cell and Tissue Research 2023;394:515-528.
https://doi.org/10.1007/s00441-023-03838-7
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2022 |
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Na Junewoo, Park Byong Seo, Jang Doohyeong, Kim Donggue, Tu Thai Hien, Ryu Youngjae, Ha Chang Man, Koch Marco, Yang Sungchil, Kim Jae Geun, Yang Sunggu.
Distinct firing activities of the hypothalamic arcuate nucleus neurons to appetite hormones.
International Journal of Molecular Sciences 2022;23(5):2609.
https://doi.org/10.3390/ijms23052609
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2019 |
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Erdem Merve, M?ckel Diana, Jumpertz Sandra, John Cathleen, Fragoulis Athanassios, Rudolph Ines, Wulfmeier Johanna, Springer Jochen, Horn Henrike, Koch Marco, Lurje Georg, Lammers Twan, Olde Damink Steven, Kroft Gregory, Gremse Felix, Cramer Thorsten.
Macrophages protect against loss of adipose tissue during cancer cachexia.
Journal of Cachexia, Sarcopenia and Muscle 2019;10(5):1128-1142.
https://doi.org/10.1002/jcsm.12450
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2018 |
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Horn Henrike, B?hme Beatrice, Dietrich Laura, Koch Marco.
Endocannabinoids in body weight control.
Pharmaceuticals 2018;11(2):55.
https://doi.org/10.3390/ph11020055
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García-Cáceres Cristina, Balland Eglantine, Prevot Vincent, Luquet Serge, Woods Stephen C., Koch Marco, Horvath Tamas L., Yi Chun-Xia, Chowen Julia A., Verkhratsky Alexei, Araque Alfonso, Bechmann Ingo, Tsch?p Matthias H..
Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism.
Nature Neuroscience 2018;22(1):7-14.
https://doi.org/10.1038/s41593-018-0286-y
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Tebbenkamp Andrew T. N., Varela Luis, Choi Jinmyung, Paredes Miguel I., Giani Alice M., Song Jae Eun, Sestan-Pesa Matija, Franjic Daniel, Sousa André M. M., Liu Zhong-Wu, Li Mingfeng, Bichsel Candace, Koch Marco, Szigeti-Buck Klara, Liu Fuchen, Li Zhuo, Kawasawa Yuka I., Paspalas Constantinos D., Mineur Yann S., Prontera Paolo, Merla Giuseppe, Picciotto Marina R., Arnsten Amy F. T., Horvath Tamas L., Sestan Nenad.
The 7q11.23 protein DNAJC30 interacts with ATP synthase and links mitochondria to brain development.
Cell 2018;175(4):1088-1104.e23.
https://doi.org/10.1016/j.cell.2018.09.014
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2017 |
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Koch Marco.
Cannabinoid receptor signaling in central regulation of feeding behavior: a mini-review.
Frontiers in Neuroscience 2017;11:293.
https://doi.org/10.3389/fnins.2017.00293
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Morozov Yury M., Koch Marco, Rakic Pasko, Horvath Tamas L..
Cannabinoid type 1 receptor-containing axons innervate NPY/AgRP neurons in the mouse arcuate nucleus.
Molecular Metabolism 2017;6(4):374-381.
https://doi.org/10.1016/j.molmet.2017.01.004
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Koch Marco.
Kopf.
In: Waschke Jens, editor. Kurzlehrbuch Anatomie. München: Elsevier; 2017. p. 265-321.
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Quarta Carmelo, Clemmensen Christoffer, Zhu Zhimeng, Yang Bin, Joseph Sini S., Lutter Dominik, Yi Chun-Xia, Graf Elisabeth, García-Cáceres Cristina, Legutko Beata, Fischer Katrin, Brommage Robert, Zizzari Philippe, Franklin Bernardo S., Krueger Martin, Koch Marco, Vettorazzi Sabine, Li Pengyun, Hofmann Susanna M., Bakhti Mostafa, Bastidas-Ponce Aimée, Lickert Heiko, Strom Tim M., Gailus-Durner Valerie, Bechmann Ingo, Perez-Tilve Diego, Tuckermann Jan, Hrabě de Angelis Martin, Sandoval Darleen, Cota Daniela, Latz Eicke, Seeley Randy J., Müller Timo D., DiMarchi Richard D., Finan Brian, Tsch?p Matthias H..
Molecular integration of incretin and glucocorticoid action reverses immunometabolic dysfunction and obesity.
Cell Metabolism 2017;26(4):620-632.e6.
https://doi.org/10.1016/j.cmet.2017.08.023
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2016 |
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Jin Sungho, Kim Jae Geun, Park Jeong Woo, Koch Marco, Horvath Tamas L., Lee Byung Ju.
Hypothalamic TLR2 triggers sickness behavior via a microglia-neuronal axis.
Scientific Reports 2016;6(1):29424.
https://doi.org/10.1038/srep29424
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2015 |
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Kim Jae?Geun, Sun Ben-Hua, Dietrich Marcelo?O., Koch Marco, Yao Gang-Qing, Diano Sabrina, Insogna Karl, Horvath Tamas?L..
AgRP neurons regulate bone mass.
Cell Reports 2015;13(1):8-14.
https://doi.org/10.1016/j.celrep.2015.08.070
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Koch Marco, Varela Luis, Kim Jae Geun, Kim Jung Dae, Hernández-Nu?o Francisco, Simonds Stephanie E., Castorena Carlos M., Vianna Claudia R., Elmquist Joel K., Morozov Yury M., Rakic Pasko, Bechmann Ingo, Cowley Michael A., Szigeti-Buck Klara, Dietrich Marcelo O., Gao Xiao-Bing, Diano Sabrina, Horvath Tamas L..
Hypothalamic POMC neurons promote cannabinoid-induced feeding.
Nature 2015;519(7541):45-50.
https://doi.org/10.1038/nature14260
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Koch Marco, Ferreirós Nerea, Geisslinger Gerd, Dehghani Faramarz, Korf Horst-Werner.
Rhythmic control of endocannabinoids in the rat pineal gland.
Chronobiology International 2015;32(6):869-874.
https://doi.org/10.3109/07420528.2015.1041596
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2014 |
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Kim Jae Geun, Suyama Shigetomo, Koch Marco, Jin Sungho, Argente-Arizon Pilar, Argente Jesús, Liu Zhong-Wu, Zimmer Marcelo R, Jeong Jin Kwon, Szigeti-Buck Klara, Gao Yuanqing, Garcia-Caceres Cristina, Yi Chun-Xia, Salmaso Natalina, Vaccarino Flora M, Chowen Julie, Diano Sabrina, Dietrich Marcelo O, Tsch?p Matthias H, Horvath Tamas L.
Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding.
Nature Neuroscience 2014;17(7):908-910.
https://doi.org/10.1038/nn.3725
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Koch Marco, Horvath T. L..
Molecular and cellular regulation of hypothalamic melanocortin neurons controlling food intake and energy metabolism.
Molecular Psychiatry 2014;19(7):752-761.
https://doi.org/10.1038/mp.2014.30
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2013 |
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Morozov Yury M., Dominguez Martin H., Varela Luis, Shanabrough Marya, Koch Marco, Horvath Tamas L., Rakic Pasko.
Antibodies to cannabinoid type 1 receptor co-react with stomatin-like protein 2 in mouse brain mitochondria.
European Journal of Neuroscience 2013;38(3):2341-2348.
https://doi.org/10.1111/ejn.12237
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Benz Alexander H., Renné Christoph, Maronde Erik, Koch Marco, Grabiec Urszula, Kallendrusch Sonja, Rengstl Benjamin, Newrzela Sebastian, Hartmann Sylvia, Hansmann Martin-Leo, Dehghani Faramarz.
Expression and functional relevance of cannabinoid receptor 1 in Hodgkin lymphoma.
PLoS ONE 2013;8(12):e81675.
https://doi.org/10.1371/journal.pone.0081675
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Kallendrusch Sonja, Kremzow Stine, Nowicki Marcin, Grabiec Urszula, Winkelmann Ria, Benz Alexander, Kraft Robert, Bechmann Ingo, Dehghani Faramarz, Koch Marco.
The G protein-coupled receptor 55 ligandl-α-lysophosphatidylinositol exerts microglia-dependent neuroprotection after excitotoxic lesion.
Glia 2013;61(11):1822-1831.
https://doi.org/10.1002/glia.22560
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2012 |
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Kallendrusch Sonja, Hobusch Constance, Ehrlich Angela, Nowicki Marcin, Ziebell Simone, Bechmann Ingo, Geisslinger Gerd, Koch Marco, Dehghani Faramarz.
Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage.
PLoS ONE 2012;7(12):e51208.
https://doi.org/10.1371/journal.pone.0051208
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Hezel Marcus, Ebrahimi Fahim, Koch Marco, Dehghani Faramarz.
Propidium iodide staining: a new application in fluorescence microscopy for analysis of cytoarchitecture in adult and developing rodent brain.
Micron 2012;43(10):1031-1038.
https://doi.org/10.1016/j.micron.2012.04.006
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Koch Marco, Horvath Tamas L..
Reward aspects of gastrointestinal hormones mediated by brain G protein–coupled receptors.
Biological Psychiatry 2012;72(5):340-342.
https://doi.org/10.1016/j.biopsych.2012.06.031
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Kallendrusch Sonja, Hobusch Constance, Ehrlich Angela, Ziebell Simone, Ueda Natsuo, Geisslinger Gerd, Koch Marco, Dehghani Faramarz.
Site-specific and time-dependent activation of the endocannabinoid system after transection of long-range projections.
PLoS ONE 2012;7(3):e33537.
https://doi.org/10.1371/journal.pone.0033537
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Grabiec Urszula, Koch Marco, Kallendrusch Sonja, Kraft Robert, Hill Kerstin, Merkwitz Claudia, Ghadban Chalid, Lutz Beat, Straiker Alex, Dehghani Faramarz.
The endocannabinoid N-arachidonoyldopamine (NADA) exerts neuroprotective effects after excitotoxic neuronal damage via cannabinoid receptor 1 (CB1).
Neuropharmacology 2012;62(4):1797-1807.
https://doi.org/10.1016/j.neuropharm.2011.11.023
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Ebrahimi Fahim, Koch Marco, Pieroh Philipp, Ghadban Chalid, Hobusch Constance, Bechmann Ingo, Dehghani Faramarz.
Time dependent neuroprotection of mycophenolate mofetil: effects on temporal dynamics in glial proliferation, apoptosis, and scar formation.
Journal of Neuroinflammation 2012;9(1):9:89.
https://doi.org/10.1186/1742-2094-9-89
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2011 |
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Koch Marco, Kreutz Susanne, B?ttger Charlotte, Grabiec Urszula, Ghadban Chalid, Korf Horst-Werner, Dehghani Faramarz.
The cannabinoid WIN 55,212-2-mediated protection of dentate gyrus granule cells is driven by CB1 receptors and modulated by TRPA1 and Cav2.2 channels.
Hippocampus 2011;21(5):554-564.
https://doi.org/10.1002/hipo.20772
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2010 |
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Yasuo Shinobu, Koch Marco, Schmidt Helmut, Ziebell Simone, Bojunga Joerg, Geisslinger Gerd, Korf Horst-Werner.
An endocannabinoid system is localized to the hypophysial pars tuberalis of Syrian hamsters and responds to photoperiodic changes.
Cell and Tissue Research 2010;340(1):127-136.
https://doi.org/10.1007/s00441-010-0930-7
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Ebrahimi Fahim, Hezel Marcus, Koch Marco, Ghadban Chalid, Korf Horst-Werner, Dehghani Faramarz.
Analyses of neuronal damage in excitotoxically lesioned organotypic hippocampal slice cultures.
Annals of Anatomy - Anatomischer Anzeiger 2010;192(4):199-204.
https://doi.org/10.1016/j.aanat.2010.06.002
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Koch Marco, Kreutz Susanne, B?ttger Charlotte, Benz Alexander, Maronde Erik, Ghadban Chalid, Korf Horst-Werner, Dehghani Faramarz.
Palmitoylethanolamide protects dentate gyrus granule cells via peroxisome proliferator-activated receptor-alpha.
Neurotoxicity Research 2010;19(2):330-340.
https://doi.org/10.1007/s12640-010-9166-2
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Bishay Philipp, Schmidt Helmut, Marian Claudiu, H?ussler Annett, Wijnvoord Nina, Ziebell Simone, Metzner Julia, Koch Marco, Myrczek Thekla, Bechmann Ingo, Kuner Rohini, Costigan Michael, Dehghani Faramarz, Geisslinger Gerd, Tegeder Irmgard.
R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids.
PLoS ONE 2010;5(5):e10628.
https://doi.org/10.1371/journal.pone.0010628
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2009 |
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Kreutz Susanne, Koch Marco, B?ttger Charlotte, Ghadban Chalid, Korf Horst-Werner, Dehghani Faramarz.
2-Arachidonoylglycerol elicits neuroprotective effects on excitotoxically lesioned dentate gyrus granule cells via abnormal-cannabidiol-sensitive receptors on microglial cells.
Glia 2009;57(3):286-294.
https://doi.org/10.1002/glia.20756
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2008 |
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Koch Marco, Habazettl Iris, Dehghani Faramarz, Korf Horst-Werner.
The rat pineal gland comprises an endocannabinoid system.
Journal of Pineal Research 2008;45(4):351-360.
https://doi.org/10.1111/j.1600-079x.2008.00597.x
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2007 |
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Kreutz Susanne, Koch Marco, Ghadban Chalid, Korf Horst-Werner, Dehghani Faramarz.
Cannabinoids and neuronal damage: differential effects of THC, AEA and 2-AG on activated microglial cells and degenerating neurons in excitotoxically lesioned rat organotypic hippocampal slice cultures.
Experimental Neurology 2007;203(1):246-257.
https://doi.org/10.1016/j.expneurol.2006.08.010
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2006 |
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Koch Marco, Dehghani Faramarz, Habazettl Iris, Schomerus Christof, Korf Horst-Werner.
Cannabinoids attenuate norepinephrine-induced melatonin biosynthesis in the rat pineal gland by reducing arylalkylamine N-acetyltransferase activity without involvement of cannabinoid receptors.
Journal of Neurochemistry 2006;98(1):267-278.
https://doi.org/10.1111/j.1471-4159.2006.03873.x
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2003 |
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Koch Marco, Mauhin Viviane, Stehle J?rg H., Schomerus Christof, Korf Horst-Werner.
Dephosphorylation of pCREB by protein serine/threonine phosphatases is involved in inactivation of Aanat gene transcription in rat pineal gland.
Journal of Neurochemistry 2003;85(1):170-179.
https://doi.org/10.1046/j.1471-4159.2003.01651.x
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2002 |
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Koch Marco, Korf H.-W..
Distribution of regulatory subunits of protein kinase A and A kinase anchor proteins (AKAP 95, 150) in rat pinealocytes.
Cell and Tissue Research 2002;310(3):331-338.
https://doi.org/10.1007/s00441-002-0633-9
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2001 |
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Vollmayer Petra, Koch Marco, Braun Norbert, Heine Petra, Servos J?rg, Israr Eltahmash, Kegel Birgit, Zimmermann Herbert.
Multiple ecto-nucleotidases in PC12 cells: identification and cellular distribution after heterologous expression.
Journal of Neurochemistry 2001;78(5):1019-1028.
https://doi.org/10.1046/j.1471-4159.2001.00480.x
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