AG 5 Buhrmann

Einfluss von Nahrungserg?nzungsmitteln auf Entzündung, Alterungsprozesse und Tumoren

Die AG 5 untersucht den Einfluss natürlicher Polyphenole auf die Interaktion der Thymozyten, T-Zellen und Adipozyten im Rahmen der mit dem Lebensalter fortschreitenden Involution des Thymus. Desweitern untersuchen wir die Wirkungsweise natürlicher Polyphenole, wie z. B. Resveratrol und Curcumin, im Rahmen von an entzündlichen Prozessen beteiligten Signaltransduktionskaskaden und an altersbedingten Umbauprozessen. Hierdurch soll der prophylaktische Einfluss natürlicher Nahrungsbestandteile wie Resveratrol auf umweltbedingte Erkrankungen wie z. B. Tumorerkrankungen des Kolons, mechanistisch verstanden werden.

Fokus I:

Die Rolle von Umweltfaktoren und des zentralnerv?sen Nervensystems auf das Tumormilieu beim kolorektalen Karzinom

Fokus II:

Resveratol vermittelte Effekte auf die Alterung des Thymus

Publikationen

2025 | 2024 | 2023 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007

2025

Buhrmann Constanze, Aggarwal B. B., Shakibaei M.. Resveratrol and chronic diseases: lessons learned from bedside. In: Aggarwal Bharat B., editor. Nutraceuticals for the prevention and treatment of chronic diseases: lessons learned from bedside. Singapore: World Scientific; in press. https://doi.org/10.1142/11520
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2024

Brockmueller Aranka, Buhrmann Constanze, Shayan Parviz, Shakibaei Mehdi. Calebin A modulates inflammatory and autophagy signals for the prevention and treatment of osteoarthritis. Frontiers in Immunology 2024;15:1363947. https://doi.org/10.3389/fimmu.2024.1363947
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Meyer Christine, Brockmueller Aranka, Buhrmann Constanze, Shakibaei Mehdi. Prevention and co-management of breast cancer-related osteoporosis using resveratrol. Nutrients 2024;16(5):708. https://doi.org/10.3390/nu16050708
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Brockmueller Aranka, Buhrmann Constanze, Moravejolahkami Amir Reza, Shakibaei Mehdi. Resveratrol and p53: how are they involved in CRC plasticity and apoptosis?. Journal of Advanced Research 2024; https://doi.org/10.1016/j.jare.2024.01.005
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2023

Brockmueller Aranka, Buhrmann Constanze, Shayan Parviz, Shakibaei Mehdi. Resveratrol induces apoptosis by modulating the reciprocal crosstalk between p53 and Sirt-1 in the CRC tumor microenvironment. Frontiers in Immunology 2023;14:1225530. https://doi.org/10.3389/fimmu.2023.1225530
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2021

Buhrmann Constanze, Brockmueller Aranka, Mueller Anna-Lena, Shayan Parviz, Shakibaei Mehdi. Curcumin attenuates environment-derived osteoarthritis by Sox9/NF-kB signaling axis. International Journal of Molecular Sciences 2021;22(14):7645. https://doi.org/10.3390/ijms22147645
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Buhrmann Constanze, Brockmueller Aranka, Harsha Choudhary, Kunnumakkara Ajaikumar B., Kubatka Peter, Aggarwal Bharat B., Shakibaei Mehdi. Evidence that tumor microenvironment initiates epithelial-to-mesenchymal transition and calebin a can suppress it in colorectal cancer cells. Frontiers in Pharmacology 2021;12:699842. https://doi.org/10.3389/fphar.2021.699842
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Bordoloi Devivasha, Padmavathi Ganesan, Banik Kishore, Devi Khwairakpam Amrita, Harsha Choudhary, Girisa Sosmitha, Buhrmann Constanze, Shakibaei Mehdi, Kunnumakkara Ajaikumar B.. Human tumor necrosis factor alpha-induced protein eight-like 1 exhibited potent anti-tumor effect through modulation of proliferation, survival, migration and invasion of lung cancer cells. Molecular and Cellular Biochemistry 2021;476(9):3303-3318. https://doi.org/10.1007/s11010-021-04060-1
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Buhrmann Constanze, Kunnumakkara Ajaikumar B., Kumar Aviral, Samec Marek, Kubatka Peter, Aggarwal Bharat B., Shakibaei Mehdi. Multitargeting effects of calebin A on malignancy of CRC cells in multicellular tumor microenvironment. Frontiers in Oncology 2021;11:650603. https://doi.org/10.3389/fonc.2021.650603
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2020

Buhrmann Constanze, Kunnumakkara Ajaikumar, Popper Bastian, Majeed Muhammed, Aggarwal Bharat, Shakibaei Mehdi. Calebin A potentiates the effect of 5-FU and TNF-β (lymphotoxin α) against human colorectal cancer cells: potential role of NF-κB. International Journal of Molecular Sciences 2020;21(7):2393. https://doi.org/10.3390/ijms21072393
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Koklesova Lenka, Liskova Alena, Samec Marek, Buhrmann Constanze, Samuel Samson Mathews, Varghese Elizabeth, Ashrafizadeh Milad, Najafi Masoud, Shakibaei Mehdi, Büsselberg Dietrich, Giordano Frank A., Golubnitschaja Olga, Kubatka Peter. Carotenoids in cancer apoptosis - the road from bench to bedside and back. Cancers 2020;12(9):2425. https://doi.org/10.3390/cancers12092425
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Buhrmann Constanze, Popper Bastian, Aggarwal Bharat B., Shakibaei Mehdi. Evidence that TNF-β suppresses osteoblast differentiation of mesenchymal stem cells and resveratrol reverses it through modulation of NF-κB, Sirt1 and Runx2. Cell and Tissue Research 2020;381(1):83-98. https://doi.org/10.1007/s00441-020-03188-8
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Samec Marek, Liskova Alena, Koklesova Lenka, Samuel Samson Mathews, Zhai Kevin, Buhrmann Constanze, Varghese Elizabeth, Abotaleb Mariam, Qaradakhi Tawar, Zulli Anthony, Kello Martin, Mojzis Jan, Zubor Pavol, Kwon Taeg Kyu, Shakibaei Mehdi, Büsselberg Dietrich, Sarria Gustavo R., Golubnitschaja Olga, Kubatka Peter. Flavonoids against the Warburg phenotype - concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism. EPMA Journal 2020;11(3):377-398. https://doi.org/10.1007/s13167-020-00217-y
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Buhrmann Constanze, Honarvar Ali, Setayeshmehr Mohsen, Karbasi Saeed, Shakibaei Mehdi, Valiani Ali. Herbal remedies as potential in cartilage tissue engineering: an overview of new therapeutic approaches and strategies. Molecules 2020;25(13):3075. https://doi.org/10.3390/molecules25133075
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Bordoloi Devivasha, Banik Kishore, Vikkurthi Rajesh, Thakur Krishan Kumar, Padmavathi Ganesan, Sailo Bethsebie Lalduhsaki, Girisa Sosmitha, Chinnathambi Arunachalam, Alahmadi Tahani Awad, Alharbi Sulaiman Ali, Buhrmann Constanze, Shakibaei Mehdi, Kunnumakkara Ajaikumar B.. Inflection of Akt/mTOR/STAT-3 cascade in TNF-α induced protein 8 mediated human lung carcinogenesis. Life Sciences 2020;262:118475. https://doi.org/10.1016/j.lfs.2020.118475
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Shaqura Mohammed, Li Li, Mohamed Doaa M., Li Xiongjuan, Treskatsch Sascha, Buhrmann Constanze, Shakibaei Mehdi, Beyer Antje, Mousa Shaaban A., Sch?fer Michael. Neuronal aldosterone elicits a distinct genomic response in pain signaling molecules contributing to inflammatory pain. Journal of Neuroinflammation 2020;17(1):183. https://doi.org/10.1186/s12974-020-01864-8
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Farkhondeh Tahereh, Mehrpour Omid, Buhrmann Constanze, Pourbagher-Shahri Ali Mohammad, Shakibaei Mehdi, Samarghandian Saeed. Organophosphorus compounds and MAPK signaling pathways. International Journal of Molecular Sciences 2020;21(12):4258. https://doi.org/10.3390/ijms21124258
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Buhrmann Constanze, Shayan Parviz, Brockmueller Aranka, Shakibaei Mehdi. Resveratrol suppresses cross-talk between colorectal cancer cells and stromal cells in multicellular tumor microenvironment: a bridge between in vitro and in vivo tumor microenvironment study. Molecules 2020;25(18):4292. https://doi.org/10.3390/molecules25184292
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Buhrmann Constanze, Yazdi Mina, Bashiri Dezfouli Ali, Samani Sahraneshin Fazel, Ebrahimi Seyed Morteza, Hamidollah Ghaffari Seyed, Yaghmaie Marjan, Barin Abbas, Shakibaei Mehdi, Shayan Parviz. Significant decrease in the viability and tumor stem cell marker expression in tumor cell lines treated with curcumin. Journal of Herbal 伟德国际_伟德国际1946$娱乐app游戏icine 2020;22:100339. https://doi.org/10.1016/j.hermed.2020.100339
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Buhrmann Constanze, Shayan Parviz, Banik Kishore, Kunnumakkara Ajaikumar B., Kubatka Peter, Koklesova Lenka, Shakibaei Mehdi. Targeting NF-κB signaling by Calebin A, a compound of turmeric, in multicellular tumor microenvironment: potential role of apoptosis induction in CRC cells. Biomedicines 2020;8(8):236. https://doi.org/10.3390/biomedicines8080236
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2019

Buhrmann Constanze, Popper Bastian, Kunnumakkara Ajaikumar B., Aggarwal Bharat B., Shakibaei Mehdi. Evidence that Calebin A, a component of curcuma longa suppresses NF-κB mediated proliferation, invasion and metastasis of human colorectal cancer induced by TNF-β (lymphotoxin). Nutrients 2019;11(12):2904. https://doi.org/10.3390/nu11122904
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Buhrmann Constanze, Yazdi Mina, Popper Bastian, Shayan Parviz, Goel Ajay, Aggarwal Bharat B., Shakibaei Mehdi. Evidence that TNF-β induces proliferation in colorectal cancer cells and resveratrol can down-modulate it. Experimental Biology and 伟德国际_伟德国际1946$娱乐app游戏icine 2019;244(1):1-12. https://doi.org/10.1177/1535370218824538
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Buhrmann Constanze, Yazdi Mina, Popper Bastian, Kunnumakkara Ajaikumar, Aggarwal Bharat, Shakibaei Mehdi. Induction of the epithelial-to-mesenchymal transition of human colorectal cancer by human TNF-β (lymphotoxin) and its reversal by resveratrol. Nutrients 2019;11(3):704. https://doi.org/10.3390/nu11030704
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2018

Buhrmann Constanze, Yazdi Mina, Popper Bastian, Shayan Parviz, Goel Ajay, Aggarwal Bharat, Shakibaei Mehdi. Resveratrol chemosensitizes TNF-β-induced survival of 5-FU-treated colorectal cancer cells. Nutrients 2018;10(7):888. https://doi.org/10.3390/nu10070888
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2017

Buhrmann Constanze, Popper Bastian, Aggarwal Bharat B., Shakibaei Mehdi. Resveratrol downregulates inflammatory pathway activated by lymphotoxin α (TNF-β) in articular chondrocytes: comparison with TNF-α. PLoS ONE 2017;12(11):e0186993. https://doi.org/10.1371/journal.pone.0186993
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Buhrmann Constanze, Shayan Parviz, Goel Ajay, Shakibaei Mehdi. Resveratrol regulates colorectal cancer cell invasion by modulation of focal adhesion molecules. Nutrients 2017;9(10):1073. https://doi.org/10.3390/nu9101073
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2016

Buhrmann Constanze, Shayan Parviz, Popper Bastian, Goel Ajay, Shakibaei Mehdi. Sirt1 is required for resveratrol-mediated chemopreventive effects in colorectal cancer cells. Nutrients 2016;8(3):145. https://doi.org/10.3390/nu8030145
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Fellows Christopher R., Gauthaman Kalamegam, Pushparaj Peter N., Abbas Mohammed, Matta Csaba, Lewis Rebecca, Buhrmann Constanze, Shakibaei Mehdi, Mobasheri Ali. Stem cells in bone and articular cartilage tissue regeneration. In: Van Pham Phuc, editor. Bone and Cartilage Regeneration. Cham: Springer International; 2016. p. 177-204. https://doi.org/10.1007/978-3-319-40144-7_9
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2015

Toden Shusuke, Okugawa Yoshinaga, Jascur Thomas, Wodarz Dominik, Komarova Natalia L., Buhrmann Constanze, Shakibaei Mehdi, Boland C. Richard, Goel Ajay. Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer. Carcinogenesis 2015;36(3):355-367. https://doi.org/10.1093/carcin/bgv006
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Shakibaei Mehdi, Kraehe Patricia, Popper Bastian, Shayan Parviz, Goel Ajay, Buhrmann Constanze. Curcumin potentiates antitumor activity of 5-fluorouracil in a 3D alginate tumor microenvironment of colorectal cancer. BMC Cancer 2015;15(1):250. https://doi.org/10.1186/s12885-015-1291-0
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Toden S., Okugawa Y., Buhrmann Constanze, Nattamai D., Anguiano E., Baldwin N., Shakibaei M., Boland C. R., Goel A.. Novel evidence for curcumin and boswellic acid-induced chemoprevention through regulation of miR-34a and miR-27a in colorectal cancer. Cancer Prevention Research 2015;8(5):431-443. https://doi.org/10.1158/1940-6207.capr-14-0354
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Buhrmann Constanze, Shayan Parviz, Kraehe Patricia, Popper Bastian, Goel Ajay, Shakibaei Mehdi. Resveratrol induces chemosensitization to 5-fluorouracil through up-regulation of intercellular junctions, epithelial-to-mesenchymal transition and apoptosis in colorectal cancer. Biochemical Pharmacology 2015;98(1):51-68. https://doi.org/10.1016/j.bcp.2015.08.105
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2014

Shakibaei Mehdi, Buhrmann Constanze, Kraehe Patricia, Shayan Parviz, Lueders Cora, Goel Ajay. Curcumin chemosensitizes 5-fluorouracil resistant MMR-deficient human colon cancer cells in high density cultures. PLoS ONE 2014;9(1):e85397. https://doi.org/10.1371/journal.pone.0085397
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Buhrmann Constanze, Kraehe Patricia, Lueders Cora, Shayan Parviz, Goel Ajay, Shakibaei Mehdi. Curcumin suppresses crosstalk between colon cancer stem cells and stromal fibroblasts in the tumor microenvironment: potential role of EMT. PLoS ONE 2014;9(9):e107514. https://doi.org/10.1371/journal.pone.0107514
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Buhrmann Constanze, Busch Franziska, Shayan Parviz, Shakibaei Mehdi. Sirtuin-1 (SIRT1) is required for promoting chondrogenic differentiation of mesenchymal stem cells. Journal of Biological Chemistry 2014;289(32):22048-22062. https://doi.org/10.1074/jbc.m114.568790
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2013

Lorenz Wolfgang, Buhrmann Constanze, Mobasheri Ali, Lueders Cora, Shakibaei Mehdi. Bacterial lipopolysaccharides form procollagen-endotoxin complexes that trigger cartilage inflammation and degeneration: implications for the development of rheumatoid arthritis. Arthritis Research & Therapy 2013;15(5):R111. https://doi.org/10.1186/ar4291
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Buhrmann Constanze, Shayan Parviz, Aggarwal Bharat B., Shakibaei Mehdi. Evidence that TNF-β (lymphotoxin α) can activate the inflammatory environment in human chondrocytes. Arthritis Research & Therapy 2013;15(6):R202. https://doi.org/10.1186/ar4393
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2012

Shakibaei Mehdi, Shayan Parviz, Busch Franziska, Aldinger Constance, Buhrmann Constanze, Lueders Cora, Mobasheri Ali. Resveratrol mediated modulation of Sirt-1/Runx2 promotes osteogenic differentiation of mesenchymal stem cells: potential role of Runx2 deacetylation. PLoS ONE 2012;7(4):e35712. https://doi.org/10.1371/journal.pone.0035712
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Mobasheri Ali, Kelly Sara, Clutterbuck Abigail L., Buhrmann Constanze, Shakibaei Mehdi. Three-dimensional, high-density and tissue engineered culture models of articular cartilage. In: Davies Jamie, editor. Replacing Animal Models: A Practical Guide to Creating and Using Culture‐Based Biomimetic Alternatives. Chichester: John Wiley; 2012. p. 167-192. https://doi.org/10.1002/9781119940685.ch16
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2011

Shakibaei M., Buhrmann Constanze, Mobasheri A.. Anti-inflammatory and anti-catabolic effects of TENDOACTIVE? on human tenocytes in vitro. Histology and Histopathology 2011;26(9):1173-1185. https://doi.org/10.14670/HH-26.1173
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Buhrmann Constanze, Mobasheri Ali, Busch Franziska, Aldinger Constance, Stahlmann Ralf, Montaseri Azadeh, Shakibaei Mehdi. Curcumin modulates nuclear factor κB (NF-κB)-mediated inflammation in human tenocytesin vitro: role of the phosphatidylinositol 3-kinase/akt pathway. Journal of Biological Chemistry 2011;286(32):28556-28566. https://doi.org/10.1074/jbc.m111.256180
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Shakibaei Mehdi, Mobasheri Ali, Buhrmann Constanze. Curcumin synergizes with resveratrol to stimulate the MAPK signaling pathway in human articular chondrocytes in vitro. Genes & Nutrition 2011;6(2):171-179. https://doi.org/10.1007/s12263-010-0179-5
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Mobasheri Ali, Richardson Stephen M., Hoyland Judith A., Buhrmann Constanze, Shakibaei Mehdi. From multipotent cells to fully differentiated connective tissue cells for regenerative medicine: emerging applications of mesenchymal stem cells. In: Eberli Daniel, editor. Regenerative 伟德国际_伟德国际1946$娱乐app游戏icine and Tissue Engineering - Cells and Biomaterials. London: InTech; 2011. p. 83-106. https://doi.org/10.5772/23747
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Montaseri Azadeh, Busch Franziska, Mobasheri Ali, Buhrmann Constanze, Aldinger Constance, Rad Jafar Soleimani, Shakibaei Mehdi. IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway. PLoS ONE 2011;6(12):e28663. https://doi.org/10.1371/journal.pone.0028663
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Shakibaei Mehdi, Buhrmann Constanze, Mobasheri Ali. Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-κB ligand RANKL activation of NF-κB signaling and inhibit osteoclastogenesis in bone-derived cells. Journal of Biological Chemistry 2011;286(13):11492-11505. https://doi.org/10.1074/jbc.m110.198713
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Schneider Philipp R. A., Buhrmann Constanze, Mobasheri Ali, Matis Ulrike, Shakibaei Mehdi. Three-dimensional high-density co-culture with primary tenocytes induces tenogenic differentiation in mesenchymal stem cells. Journal of Orthopaedic Research 2011;29(9):1351-1360. https://doi.org/10.1002/jor.21400
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2010

Buhrmann Constanze, Mobasheri Ali, Matis Ulrike, Shakibaei Mehdi. Curcumin mediated suppression of nuclear factor-κB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment. Arthritis Research & Therapy 2010;12(4):R127. https://doi.org/10.1186/ar3065
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Richardson Stephen M., Hoyland Judith A., Mobasheri Reza, Csaki Constanze, Shakibaei Mehdi, Mobasheri Ali. Mesenchymal stem cells in regenerative medicine: opportunities and challenges for articular cartilage and intervertebral disc tissue engineering. Journal of Cellular Physiology 2010;222(1):23-32. https://doi.org/10.1002/jcp.21915
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2009

Seifarth Claudia, Buhrmann Constanze, Shakibaei M.. Anabolic actions of IGF-I and TGF-β1 on human articular chondrocytes in vitro: potential applications in tissue engineering. Histology and Histopathology 2009;24(10):1245-1262. https://doi.org/10.14670/HH-24.1245
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Csaki Constanze, Matis U., Mobasheri A., Shakibaei M.. Co-culture of canine mesenchymal stem cells with primary bone-derived osteoblasts promotes osteogenic differentiation. Histochemistry and Cell Biology 2009;131(2):251-266. https://doi.org/10.1007/s00418-008-0524-6
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Mobasheri A., Buhrmann Constanze, Clutterbuck A. L., Rahmanzadeh M., Shakibaei M.. Mesenchymal stem cells in connective tissue engineering and regenerative medicine for cartilage repair and osteoarthritis therapy. Histology and Histopathology 2009;24(3):347-366. https://doi.org/10.14670/HH-24.347
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Csaki Constanze, Mobasheri Ali, Shakibaei Mehdi. Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1β-induced NF-κB-mediated inflammation and apoptosis. Arthritis Research & Therapy 2009;11(6):R165. https://doi.org/10.1186/ar2850
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2008

Shakibaei Mehdi, Csaki Constanze, Mobasheri Ali. Diverse roles of integrin receptors in articular cartilage. Berlin: Springer; 2008. https://doi.org/10.1007/978-3-540-78771-6
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Shakibaei M., Csaki Constanze, Rahmanzadeh M., Putz R.. Interaktion zwischen humanen Chondrozyten und extrazellul?rer Matrix in vitro: ein Beitrag zur autologen Chondrozytentransplantation. Der Orthop?de 2008;37(5):440-447. https://doi.org/10.1007/s00132-008-1260-2
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Csaki Constanze, Schneider P. R. A., Shakibaei M.. Mesenchymal stem cells as a potential pool for cartilage tissue engineering. Annals of Anatomy - Anatomischer Anzeiger 2008;190(5):395-412. https://doi.org/10.1016/j.aanat.2008.07.007
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Csaki Constanze, Keshishzadeh Nerses, Fischer Karoline, Shakibaei Mehdi. Regulation of inflammation signalling by resveratrol in human chondrocytes in vitro. Biochemical Pharmacology 2008;75(3):677-687. https://doi.org/10.1016/j.bcp.2007.09.014
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Shakibaei Mehdi, Csaki Constanze, Nebrich Simone, Mobasheri Ali. Resveratrol suppresses interleukin-1β-induced inflammatory signaling and apoptosis in human articular chondrocytes: potential for use as a novel nutraceutical for the treatment of osteoarthritis. Biochemical Pharmacology 2008;76(11):1426-1439. https://doi.org/10.1016/j.bcp.2008.05.029
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2007

Csaki Constanze, Matis U., Mobasheri A., Ye H., Shakibaei M.. Chondrogenesis, osteogenesis and adipogenesis of canine mesenchymal stem cells: a biochemical, morphological and ultrastructural study. Histochemistry and Cell Biology 2007;128(6):507-520. https://doi.org/10.1007/s00418-007-0337-z
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