PD Dr. Constanze Buhrmann
Akademische Oberr?tin,
Lehr- und Fortbildungsbeauftragte
Anatomie und Zellbiologie
Telefon: | +49 (0) 821 598 - 3139 |
E-Mail: | constanze.buhrmann@med.uni-augsburgmed.uni-augsburg.de () |
Raum: | 1005 (Sigma-Technopark Geb?ude 10) |
Adresse: | Werner-von-Siemens-Stra?e 6 (Sigma Technopark), 86159 Augsburg |
Publikationen
2025
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2024
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2023
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2021
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2020
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2019
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2018
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2017
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2016
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2015
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2014
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2013
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2012
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2011
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2010
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2009
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2008
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2007
2025 |
Buhrmann Constanze, Aggarwal B. B., Shakibaei M..
Resveratrol and chronic diseases: lessons learned from bedside.
In: Aggarwal Bharat B., editor. Nutraceuticals for the prevention and treatment of chronic diseases: lessons learned from bedside. Singapore: World Scientific; in press.
https://doi.org/10.1142/11520
BibTeX | RIS | DOI |
2024 |
Brockmueller Aranka, Buhrmann Constanze, Shayan Parviz, Shakibaei Mehdi.
Calebin A modulates inflammatory and autophagy signals for the prevention and treatment of osteoarthritis.
Frontiers in Immunology 2024;15:1363947.
https://doi.org/10.3389/fimmu.2024.1363947
PDF | BibTeX | RIS | DOI |
Meyer Christine, Brockmueller Aranka, Buhrmann Constanze, Shakibaei Mehdi.
Prevention and co-management of breast cancer-related osteoporosis using resveratrol.
Nutrients 2024;16(5):708.
https://doi.org/10.3390/nu16050708
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Brockmueller Aranka, Buhrmann Constanze, Moravejolahkami Amir Reza, Shakibaei Mehdi.
Resveratrol and p53: how are they involved in CRC plasticity and apoptosis?.
Journal of Advanced Research 2024;66:181-195.
https://doi.org/10.1016/j.jare.2024.01.005
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2023 |
Brockmueller Aranka, Buhrmann Constanze, Shayan Parviz, Shakibaei Mehdi.
Resveratrol induces apoptosis by modulating the reciprocal crosstalk between p53 and Sirt-1 in the CRC tumor microenvironment.
Frontiers in Immunology 2023;14:1225530.
https://doi.org/10.3389/fimmu.2023.1225530
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2021 |
Buhrmann Constanze, Brockmueller Aranka, Mueller Anna-Lena, Shayan Parviz, Shakibaei Mehdi.
Curcumin attenuates environment-derived osteoarthritis by Sox9/NF-kB signaling axis.
International Journal of Molecular Sciences 2021;22(14):7645.
https://doi.org/10.3390/ijms22147645
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Buhrmann Constanze, Brockmueller Aranka, Mueller Anna-Lena, Shayan Parviz, Shakibaei Mehdi.
Curcumin attenuates environment-derived osteoarthritis by Sox9/NF-kB signaling axis.
International Journal of Molecular Sciences 2021;22(14):7645.
https://doi.org/10.3390/ijms22147645
PDF | BibTeX | RIS | DOI |
Buhrmann Constanze, Brockmueller Aranka, Harsha Choudhary, Kunnumakkara Ajaikumar B., Kubatka Peter, Aggarwal Bharat B., Shakibaei Mehdi.
Evidence that tumor microenvironment initiates epithelial-to-mesenchymal transition and calebin a can suppress it in colorectal cancer cells.
Frontiers in Pharmacology 2021;12:699842.
https://doi.org/10.3389/fphar.2021.699842
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Bordoloi Devivasha, Padmavathi Ganesan, Banik Kishore, Devi Khwairakpam Amrita, Harsha Choudhary, Girisa Sosmitha, Buhrmann Constanze, Shakibaei Mehdi, Kunnumakkara Ajaikumar B..
Human tumor necrosis factor alpha-induced protein eight-like 1 exhibited potent anti-tumor effect through modulation of proliferation, survival, migration and invasion of lung cancer cells.
Molecular and Cellular Biochemistry 2021;476(9):3303-3318.
https://doi.org/10.1007/s11010-021-04060-1
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Buhrmann Constanze, Kunnumakkara Ajaikumar B., Kumar Aviral, Samec Marek, Kubatka Peter, Aggarwal Bharat B., Shakibaei Mehdi.
Multitargeting effects of calebin A on malignancy of CRC cells in multicellular tumor microenvironment.
Frontiers in Oncology 2021;11:650603.
https://doi.org/10.3389/fonc.2021.650603
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2020 |
Buhrmann Constanze, Kunnumakkara Ajaikumar, Popper Bastian, Majeed Muhammed, Aggarwal Bharat, Shakibaei Mehdi.
Calebin A potentiates the effect of 5-FU and TNF-β (lymphotoxin α) against human colorectal cancer cells: potential role of NF-κB.
International Journal of Molecular Sciences 2020;21(7):2393.
https://doi.org/10.3390/ijms21072393
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Koklesova Lenka, Liskova Alena, Samec Marek, Buhrmann Constanze, Samuel Samson Mathews, Varghese Elizabeth, Ashrafizadeh Milad, Najafi Masoud, Shakibaei Mehdi, Büsselberg Dietrich, Giordano Frank A., Golubnitschaja Olga, Kubatka Peter.
Carotenoids in cancer apoptosis - the road from bench to bedside and back.
Cancers 2020;12(9):2425.
https://doi.org/10.3390/cancers12092425
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Buhrmann Constanze, Popper Bastian, Aggarwal Bharat B., Shakibaei Mehdi.
Evidence that TNF-β suppresses osteoblast differentiation of mesenchymal stem cells and resveratrol reverses it through modulation of NF-κB, Sirt1 and Runx2.
Cell and Tissue Research 2020;381(1):83-98.
https://doi.org/10.1007/s00441-020-03188-8
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Samec Marek, Liskova Alena, Koklesova Lenka, Samuel Samson Mathews, Zhai Kevin, Buhrmann Constanze, Varghese Elizabeth, Abotaleb Mariam, Qaradakhi Tawar, Zulli Anthony, Kello Martin, Mojzis Jan, Zubor Pavol, Kwon Taeg Kyu, Shakibaei Mehdi, Büsselberg Dietrich, Sarria Gustavo R., Golubnitschaja Olga, Kubatka Peter.
Flavonoids against the Warburg phenotype - concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism.
EPMA Journal 2020;11(3):377-398.
https://doi.org/10.1007/s13167-020-00217-y
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Buhrmann Constanze, Honarvar Ali, Setayeshmehr Mohsen, Karbasi Saeed, Shakibaei Mehdi, Valiani Ali.
Herbal remedies as potential in cartilage tissue engineering: an overview of new therapeutic approaches and strategies.
Molecules 2020;25(13):3075.
https://doi.org/10.3390/molecules25133075
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Bordoloi Devivasha, Banik Kishore, Vikkurthi Rajesh, Thakur Krishan Kumar, Padmavathi Ganesan, Sailo Bethsebie Lalduhsaki, Girisa Sosmitha, Chinnathambi Arunachalam, Alahmadi Tahani Awad, Alharbi Sulaiman Ali, Buhrmann Constanze, Shakibaei Mehdi, Kunnumakkara Ajaikumar B..
Inflection of Akt/mTOR/STAT-3 cascade in TNF-α induced protein 8 mediated human lung carcinogenesis.
Life Sciences 2020;262:118475.
https://doi.org/10.1016/j.lfs.2020.118475
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Shaqura Mohammed, Li Li, Mohamed Doaa M., Li Xiongjuan, Treskatsch Sascha, Buhrmann Constanze, Shakibaei Mehdi, Beyer Antje, Mousa Shaaban A., Sch?fer Michael.
Neuronal aldosterone elicits a distinct genomic response in pain signaling molecules contributing to inflammatory pain.
Journal of Neuroinflammation 2020;17(1):183.
https://doi.org/10.1186/s12974-020-01864-8
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Farkhondeh Tahereh, Mehrpour Omid, Buhrmann Constanze, Pourbagher-Shahri Ali Mohammad, Shakibaei Mehdi, Samarghandian Saeed.
Organophosphorus compounds and MAPK signaling pathways.
International Journal of Molecular Sciences 2020;21(12):4258.
https://doi.org/10.3390/ijms21124258
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Buhrmann Constanze, Shayan Parviz, Brockmueller Aranka, Shakibaei Mehdi.
Resveratrol suppresses cross-talk between colorectal cancer cells and stromal cells in multicellular tumor microenvironment: a bridge between in vitro and in vivo tumor microenvironment study.
Molecules 2020;25(18):4292.
https://doi.org/10.3390/molecules25184292
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Buhrmann Constanze, Yazdi Mina, Bashiri Dezfouli Ali, Samani Sahraneshin Fazel, Ebrahimi Seyed Morteza, Hamidollah Ghaffari Seyed, Yaghmaie Marjan, Barin Abbas, Shakibaei Mehdi, Shayan Parviz.
Significant decrease in the viability and tumor stem cell marker expression in tumor cell lines treated with curcumin.
Journal of Herbal 伟德国际_伟德国际1946$娱乐app游戏icine 2020;22:100339.
https://doi.org/10.1016/j.hermed.2020.100339
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Buhrmann Constanze, Shayan Parviz, Banik Kishore, Kunnumakkara Ajaikumar B., Kubatka Peter, Koklesova Lenka, Shakibaei Mehdi.
Targeting NF-κB signaling by Calebin A, a compound of turmeric, in multicellular tumor microenvironment: potential role of apoptosis induction in CRC cells.
Biomedicines 2020;8(8):236.
https://doi.org/10.3390/biomedicines8080236
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2019 |
Buhrmann Constanze, Popper Bastian, Kunnumakkara Ajaikumar B., Aggarwal Bharat B., Shakibaei Mehdi.
Evidence that Calebin A, a component of curcuma longa suppresses NF-κB mediated proliferation, invasion and metastasis of human colorectal cancer induced by TNF-β (lymphotoxin).
Nutrients 2019;11(12):2904.
https://doi.org/10.3390/nu11122904
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Buhrmann Constanze, Yazdi Mina, Popper Bastian, Shayan Parviz, Goel Ajay, Aggarwal Bharat B., Shakibaei Mehdi.
Evidence that TNF-β induces proliferation in colorectal cancer cells and resveratrol can down-modulate it.
Experimental Biology and 伟德国际_伟德国际1946$娱乐app游戏icine 2019;244(1):1-12.
https://doi.org/10.1177/1535370218824538
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Buhrmann Constanze, Yazdi Mina, Popper Bastian, Kunnumakkara Ajaikumar, Aggarwal Bharat, Shakibaei Mehdi.
Induction of the epithelial-to-mesenchymal transition of human colorectal cancer by human TNF-β (lymphotoxin) and its reversal by resveratrol.
Nutrients 2019;11(3):704.
https://doi.org/10.3390/nu11030704
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2018 |
Buhrmann Constanze, Yazdi Mina, Popper Bastian, Shayan Parviz, Goel Ajay, Aggarwal Bharat, Shakibaei Mehdi.
Resveratrol chemosensitizes TNF-β-induced survival of 5-FU-treated colorectal cancer cells.
Nutrients 2018;10(7):888.
https://doi.org/10.3390/nu10070888
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2017 |
Buhrmann Constanze, Popper Bastian, Aggarwal Bharat B., Shakibaei Mehdi.
Resveratrol downregulates inflammatory pathway activated by lymphotoxin α (TNF-β) in articular chondrocytes: comparison with TNF-α.
PLoS ONE 2017;12(11):e0186993.
https://doi.org/10.1371/journal.pone.0186993
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Buhrmann Constanze, Shayan Parviz, Goel Ajay, Shakibaei Mehdi.
Resveratrol regulates colorectal cancer cell invasion by modulation of focal adhesion molecules.
Nutrients 2017;9(10):1073.
https://doi.org/10.3390/nu9101073
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2016 |
Buhrmann Constanze, Shayan Parviz, Popper Bastian, Goel Ajay, Shakibaei Mehdi.
Sirt1 is required for resveratrol-mediated chemopreventive effects in colorectal cancer cells.
Nutrients 2016;8(3):145.
https://doi.org/10.3390/nu8030145
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Fellows Christopher R., Gauthaman Kalamegam, Pushparaj Peter N., Abbas Mohammed, Matta Csaba, Lewis Rebecca, Buhrmann Constanze, Shakibaei Mehdi, Mobasheri Ali.
Stem cells in bone and articular cartilage tissue regeneration.
In: Van Pham Phuc, editor. Bone and Cartilage Regeneration. Cham: Springer International; 2016. p. 177-204.
https://doi.org/10.1007/978-3-319-40144-7_9
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2015 |
Toden Shusuke, Okugawa Yoshinaga, Jascur Thomas, Wodarz Dominik, Komarova Natalia L., Buhrmann Constanze, Shakibaei Mehdi, Boland C. Richard, Goel Ajay.
Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer.
Carcinogenesis 2015;36(3):355-367.
https://doi.org/10.1093/carcin/bgv006
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Shakibaei Mehdi, Kraehe Patricia, Popper Bastian, Shayan Parviz, Goel Ajay, Buhrmann Constanze.
Curcumin potentiates antitumor activity of 5-fluorouracil in a 3D alginate tumor microenvironment of colorectal cancer.
BMC Cancer 2015;15(1):250.
https://doi.org/10.1186/s12885-015-1291-0
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Toden S., Okugawa Y., Buhrmann Constanze, Nattamai D., Anguiano E., Baldwin N., Shakibaei M., Boland C. R., Goel A..
Novel evidence for curcumin and boswellic acid-induced chemoprevention through regulation of miR-34a and miR-27a in colorectal cancer.
Cancer Prevention Research 2015;8(5):431-443.
https://doi.org/10.1158/1940-6207.capr-14-0354
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Buhrmann Constanze, Shayan Parviz, Kraehe Patricia, Popper Bastian, Goel Ajay, Shakibaei Mehdi.
Resveratrol induces chemosensitization to 5-fluorouracil through up-regulation of intercellular junctions, epithelial-to-mesenchymal transition and apoptosis in colorectal cancer.
Biochemical Pharmacology 2015;98(1):51-68.
https://doi.org/10.1016/j.bcp.2015.08.105
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2014 |
Shakibaei Mehdi, Buhrmann Constanze, Kraehe Patricia, Shayan Parviz, Lueders Cora, Goel Ajay.
Curcumin chemosensitizes 5-fluorouracil resistant MMR-deficient human colon cancer cells in high density cultures.
PLoS ONE 2014;9(1):e85397.
https://doi.org/10.1371/journal.pone.0085397
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Buhrmann Constanze, Kraehe Patricia, Lueders Cora, Shayan Parviz, Goel Ajay, Shakibaei Mehdi.
Curcumin suppresses crosstalk between colon cancer stem cells and stromal fibroblasts in the tumor microenvironment: potential role of EMT.
PLoS ONE 2014;9(9):e107514.
https://doi.org/10.1371/journal.pone.0107514
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Buhrmann Constanze, Busch Franziska, Shayan Parviz, Shakibaei Mehdi.
Sirtuin-1 (SIRT1) is required for promoting chondrogenic differentiation of mesenchymal stem cells.
Journal of Biological Chemistry 2014;289(32):22048-22062.
https://doi.org/10.1074/jbc.m114.568790
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2013 |
Lorenz Wolfgang, Buhrmann Constanze, Mobasheri Ali, Lueders Cora, Shakibaei Mehdi.
Bacterial lipopolysaccharides form procollagen-endotoxin complexes that trigger cartilage inflammation and degeneration: implications for the development of rheumatoid arthritis.
Arthritis Research & Therapy 2013;15(5):R111.
https://doi.org/10.1186/ar4291
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Buhrmann Constanze, Shayan Parviz, Aggarwal Bharat B., Shakibaei Mehdi.
Evidence that TNF-β (lymphotoxin α) can activate the inflammatory environment in human chondrocytes.
Arthritis Research & Therapy 2013;15(6):R202.
https://doi.org/10.1186/ar4393
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