伟德国际_伟德国际1946$娱乐app游戏

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Physiologie

  1. Universit?t
  2. Fakult?ten
  3. 伟德国际_伟德国际1946$娱乐app游戏izinische Fakult?t
  4. Lehrstühle und Professuren
  5. Physiologie
  6. Team Prof. Dr. Rudolf Schubert
  7. PD Dr. Kristin Pogoda

PD. Dr. Kristin Pogoda

Arbeitsgruppenleiterin ?Zell-Zell-Kommunikation“
Physiologie
Telefon: +49 821 598 - 71121
E-Mail:
Raum: Garching1.03.55 (伟德国际_伟德国际1946$娱乐app游戏izinische Fakult?t - Lehrgeb?ude LGB)
Adresse: Am 伟德国际_伟德国际1946$娱乐app游戏izincampus 2, 86156 Augsburg

Forschungsschwerpunkte

Role of connexins during vascular remodeling processes
Mutations within the PKA phosphorylation site of Cx43 additionally increase the migration enhancing effect of Cx43. Modified from: Kameritsch P, Kiemer F, Beck H, Mannell H, Pohl U and Pogoda K. PKA negatively modulates the migration enhancing effect of ? Universit?t Augsburg
Regulation of myoendothelial gap junctions in the vascular system
Composition and regulation of myoendothelial gap junctions. Pogoda K and Kameritsch P. Molecular regulation of myoendothelial gap junctions. Curr Opin Pharmacol. 2019 Apr 15;45:16-22. ? Universit?t Augsburg
Functional impact of small connexin isoforms
Channel-independent and channel-dependent functions of connexins are regulated via posttranslational modifications (PTM) and/or protein-protein interactions at the cytoplasmic carboxyl tail. ? Universit?t Augsburg

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Functional impact and regulation of connexins and gap junctions in the vascular system

Role of connexins during vascular remodeling processes

Role of connexins during vascular remodeling processes

Functional impact of small connexin isoforms

Functional impact of small connexin isoforms

Regulation of myoendothelial gap junctions in the vascular system

Regulation of myoendothelial gap junctions in the vascular system

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Publikationen

2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2010 | 2006 | 2004 | 2003 | 2002 | 2001

2023
Kipka Hannah, Schaflinger Rebecca, Tomasi Roland, Pogoda Kristin, Mannell Hanna. The effects of the levosimendan metabolites OR-1855 and OR-1896 on endothelial pro-inflammatory responses. Biomedicines 2023;11(3):918. https://doi.org/10.3390/biomedicines11030918
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2022
Tomasi Stephanie, Li Lei, Hinske Ludwig Christian, Tomasi Roland, Amini Martina, Strau? Gabriele, Müller Martin Bernhard, Hirschberger Simon, Peterss Sven, Effinger David, Pogoda Kristin, Kreth Simone, Hübner Max. A functional network driven by microRNA-125a regulates monocyte trafficking in acute inflammation. International Journal of Molecular Sciences 2022;23(18):10684. https://doi.org/10.3390/ijms231810684
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Müller Martin Bernhard, Hübner Max, Li Lei, Tomasi Stephanie, Lie?ke Valena, Effinger David, Hirschberger Simon, Pogoda Kristin, Sperandio Markus, Kreth Simone. Cell-crossing functional network driven by microRNA-125a regulates endothelial permeability and monocyte trafficking in acute inflammation. Frontiers in Immunology 2022;13:826047. https://doi.org/10.3389/fimmu.2022.826047
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Mannell Hanna, Kameritsch Petra, Beck Heike, Pfeifer Alexander, Pohl Ulrich, Pogoda Kristin. Cx43 promotes endothelial cell migration and angiogenesis via the tyrosine phosphatase SHP-2. International Journal of Molecular Sciences 2022;23(1):294. https://doi.org/10.3390/ijms23010294
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2021
Kameritsch Petra, Singer Miriam, Nuernbergk Christoph, Rios Natalia, Reyes Aníbal M., Schmidt Kjestine, Kirsch Julian, Schneider Holger, Müller Susanna, Pogoda Kristin, Cui Ruicen, Kirchner Thomas, de Wit Cor, Lange-Sperandio B?rbel, Pohl Ulrich, Conrad Marcus, Radi Rafael, Beck Heike. The mitochondrial thioredoxin reductase system (TrxR2) in vascular endothelium controls peroxynitrite levels and tissue integrity. Proceedings of the National Academy of Sciences 2021;118(7):e1921828118. https://doi.org/10.1073/pnas.1921828118
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2020
Rivière Thibaud, Bader Almke, Pogoda Kristin, Walzog Barbara, Maier-Begandt Daniela. Structure and emerging functions of LRCH proteins in leukocyte biology. Frontiers in Cell and Developmental Biology 2020;8:584134. https://doi.org/10.3389/fcell.2020.584134
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Hübner Max, Effinger David, Wu Tingting, Strau? Gabriele, Pogoda Kristin, Kreth Friedrich-Wilhelm, Kreth Simone. The IL-1 antagonist anakinra attenuates glioblastoma aggressiveness by dampening tumor-associated inflammation. Cancers 2020;12(2):433. https://doi.org/10.3390/cancers12020433
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Kameritsch Petra, Pogoda Kristin. The role of connexin 43 and pannexin 1 during acute inflammation. Frontiers in Physiology 2020;11:594097. https://doi.org/10.3389/fphys.2020.594097
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2019
Aasen Trond, Leithe Edward, Graham Sheila V., Kameritsch Petra, Mayán María D., Mesnil Marc, Pogoda Kristin, Tabernero Arantxa. Connexins in cancer: bridging the gap to the clinic. Oncogene 2019;38(23):4429-4451. https://doi.org/10.1038/s41388-019-0741-6
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Pogoda Kristin, Kameritsch P., Mannell Hanna, Pohl U.. Connexins in the control of vasomotor function. Acta Physiologica 2019;225(1):e13108. https://doi.org/10.1111/apha.13108
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Heun Yvonn, Pircher Joachim, Czermak Thomas, Bluem Philipp, Hupel Georg, Bohmer Monica, Kraemer Bjoern F., Pogoda Kristin, Pfeifer Alexander, Woernle Markus, Ribeiro Andrea, Hübner Max, Kreth Simone, Claus Ralf A., Weis Sebastian, Ungelenk Luisa, Kr?tz Florian, Pohl Ulrich, Mannell Hanna. Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in sepsis. EBio伟德国际_伟德国际1946$娱乐app游戏icine 2019;42:120-132. https://doi.org/10.1016/j.ebiom.2019.03.034
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Pogoda Kristin, Kameritsch Petra. Molecular regulation of myoendothelial gap junctions. Current Opinion in Pharmacology 2019;45:16-22. https://doi.org/10.1016/j.coph.2019.03.006
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Kameritsch Petra, Kiemer Felizitas, Mannell Hanna, Beck Heike, Pohl Ulrich, Pogoda Kristin. PKA negatively modulates the migration enhancing effect of Connexin 43. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2019;1866(5):828-838. https://doi.org/10.1016/j.bbamcr.2019.02.001
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Heun Yvonn, Grundler Groterhorst Katharina, Pogoda Kristin, Kraemer Bjoern F., Pfeifer Alexander, Pohl Ulrich, Mannell Hanna. The phosphatase SHP-2 activates HIF-1α in wounds in vivo by inhibition of 26S proteasome activity. International Journal of Molecular Sciences 2019;20(18):4404. https://doi.org/10.3390/ijms20184404
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2018
Mesnil Marc, Aasen Trond, Boucher Jonathan, Chépied Amandine, Cronier Laurent, Defamie Norah, Kameritsch Petra, Laird Dale W., Lampe Paul D., Lathia Justin D., Leithe Edward, Mehta Parmender P., Monvoisin Arnaud, Pogoda Kristin, Sin Wun-Chey, Tabernero Arantxa, Yamasaki Hiroshi, Yeh Elizabeth S., Dagli Maria Lucia Zaidan, Naus Christian C.. An update on minding the gap in cancer. Biochimica et Biophysica Acta (BBA) - Biomembranes 2018;1860(1):237-243. https://doi.org/10.1016/j.bbamem.2017.06.015
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2017
Heun Yvonn, Pogoda Kristin, Anton Martina, Pircher Joachim, Pfeifer Alexander, Woernle Markus, Ribeiro Andrea, Kameritsch Petra, Mykhaylyk Olga, Plank Christian, Kroetz Florian, Pohl Ulrich, Mannell Hanna. HIF-1α dependent wound healing angiogenesis in?vivo can be controlled by site-specific lentiviral magnetic targeting of SHP-2. Molecular Therapy 2017;25(7):1616-1627. https://doi.org/10.1016/j.ymthe.2017.04.007
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Pogoda Kristin, Mannell Hanna, Blodow Stephanie, Schneider Holger, Schubert Kai Michael, Qiu Jiehua, Schmidt Andreas, Imhof Axel, Beck Heike, Tanase Laurentia Irina, Pfeifer Alexander, Pohl Ulrich, Kameritsch Petra. NO augments endothelial reactivity by reducing myoendothelial calcium signal spreading: a novel role for Cx37 (Connexin 37) and the protein tyrosine phosphatase SHP-2. Arteriosclerosis, Thrombosis, and Vascular Biology 2017;37(12):2280-2290. https://doi.org/10.1161/atvbaha.117.309913
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2016
Kirsch Julian, Schneider Holger, Pagel Judith-Irina, Rehberg Markus, Singer Miriam, Hellfritsch Juliane, Chillo Omary, Schubert Kai Michael, Qiu Jiehua, Pogoda Kristin, Kameritsch Petra, Uhl Bernd, Pircher Joachim, Deindl Elisabeth, Müller Susanna, Kirchner Thomas, Pohl Ulrich, Conrad Marcus, Beck Heike. Endothelial dysfunction, and a prothrombotic, proinflammatory phenotype is caused by loss of mitochondrial thioredoxin reductase in endothelium. Arteriosclerosis, Thrombosis, and Vascular Biology 2016;36(9):1891-1899. https://doi.org/10.1161/atvbaha.116.307843
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Pogoda Kristin, Kameritsch Petra, Retamal Mauricio A., Vega José L.. Regulation of gap junction channels and hemichannels by phosphorylation and redox changes: a revision. BMC Cell Biology 2016;17(S1):11. https://doi.org/10.1186/s12860-016-0099-3
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2015
Kameritsch Petra, Kiemer Felizitas, Beck Heike, Pohl Ulrich, Pogoda Kristin. Cx43 increases serum induced filopodia formation via activation of p21-activated protein kinase 1. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2015;1853(11):2907-2917. https://doi.org/10.1016/j.bbamcr.2015.08.004
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Hellfritsch Juliane, Kirsch Julian, Schneider Manuela, Fluege Tamara, Wortmann Markus, Frijhoff Jeroen, Dagnell Markus, Fey Theres, Esposito Irene, K?lle Pirkko, Pogoda Kristin, Angeli José Pedro Friedmann, Ingold Irina, Kuhlencordt Peter, ?stman Arne, Pohl Ulrich, Conrad Marcus, Beck Heike. Knockout of mitochondrial thioredoxin reductase stabilizes prolyl hydroxylase 2 and inhibits tumor growth and tumor-derived angiogenesis. Antioxidants & Redox Signaling 2015;22(11):938-950. https://doi.org/10.1089/ars.2014.5889
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2014
Pogoda Kristin, Füller Monika, Pohl Ulrich, Kameritsch Petra. NO, via its target Cx37, modulates calcium signal propagation selectively at myoendothelial gap junctions. Cell Communication and Signaling 2014;12(1):33. https://doi.org/10.1186/1478-811x-12-33
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2013
Kameritsch P., Khandoga N., Pohl U., Pogoda Kristin. Gap junctional communication promotes apoptosis in a connexin-type-dependent manner. Cell Death & Disease 2013;4:e584. https://doi.org/10.1038/cddis.2013.105
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2012
Kameritsch Petra, Pogoda Kristin, Pohl Ulrich. Channel-independent influence of connexin 43 on cell migration. Biochimica et Biophysica Acta (BBA) - Biomembranes 2012;1818(8):1993-2001. https://doi.org/10.1016/j.bbamem.2011.11.016
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Kameritsch Petra, Pogoda Kristin, Ritter Angela, Münzing Silvia, Pohl Ulrich. Gap junctional communication controls the overall endothelial calcium response to vasoactive agonists. Cardiovascular Research 2012;93(3):508-515. https://doi.org/10.1093/cvr/cvr345
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2010
Behrens Juliane, Kameritsch Petra, Wallner Stefan, Pohl Ulrich, Pogoda Kristin. The carboxyl tail of Cx43 augments p38 mediated cell migration in a gap junction-independent manner. European Journal of Cell Biology 2010;89(11):828-838. https://doi.org/10.1016/j.ejcb.2010.06.003
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2006
Pammer Johannes, Reinisch Christine, Birner Peter, Pogoda Kristin, Sturzl Michael, Tschachler Erwin. Interferon-α prevents apoptosis of endothelial cells after short-term exposure but induces replicative senescence after continuous stimulation. Laboratory Investigation 2006;86(10):997-1007. https://doi.org/10.1038/labinvest.3700461
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2004
Naschberger Elisabeth, Werner Thomas, Vicente Ana B., Guenzi Eric, T?polt Kristin, Leubert René, Lubeseder-Martellato Clara, Nelson Peter J., Stürzl Michael. Nuclear factor-kappaB motif and interferon-alpha-stimulated response element co-operate in the activation of guanylate-binding protein-1 expression by inflammatory cytokines in endothelial cells. Biochemical Journal 2004;379(2):409-420. https://doi.org/10.1042/bj20031873
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2003
Guenzi Eric, T?polt Kristin, Lubeseder‐Martellato Clara, J?rg Anita, Naschberger Elisabeth, Benelli Roberto, Albini Adriana, Stürzl Michael. The guanylate binding protein-1 GTPase controls the invasive and angiogenic capability of endothelial cells through inhibition of MMP-1 expression. The EMBO Journal 2003;22(15):3772-3782. https://doi.org/10.1093/emboj/cdg382
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2002
Lubeseder-Martellato Clara, Guenzi Eric, J?rg Anita, T?polt Kristin, Naschberger Elisabeth, Kremmer Elisabeth, Zietz Christian, Tschachler Erwin, Hutzler Peter, Schwemmle Martin, Matzen Kathrin, Grimm Thomas, Ensoli Barbara, Stürzl Michael. Guanylate-binding protein-1 expression is selectively induced by inflammatory cytokines and is an activation marker of endothelial cells during inflammatory diseases. The American Journal of Pathology 2002;161(5):1749-1759. https://doi.org/10.1016/s0002-9440(10)64452-5
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2001
Guenzi E., T?polt Kristin, Cornali Emmanuelle, Lubeseder‐Martellato Clara, J?rg Anita, Matzen Kathrin, Zietz Christian, Kremmer Elisabeth, Nappi Filomena, Schwemmle Martin, Hohenadl Christine, Barillari Giovanni, Tschachler Erwin, Monini Paolo, Ensoli Barbara, Stürzl Michael. The helical domain of GBP-1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines. The EMBO Journal 2001;20(20):5568-5577. https://doi.org/10.1093/emboj/20.20.5568
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Lebenslauf

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Vita

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1990-1995?????????????????????????? study of food science/biotechnology, Humboldt-伟德国际_伟德国际1946$娱乐app游戏 Berlin?

1995-1997?????????????????????????? post-graduate studies in economic sciences, Technical 伟德国际_伟德国际1946$娱乐app游戏 Dresden

1996-1997?????????????????????????? erasmus scholarship, 伟德国际_伟德国际1946$娱乐app游戏 of Rome, Italy

1998-1999?????????????????????????? technical assistant, Gene Center Munich, LMU Munich

2000-2004?????????????????????????? PhD thesis, Helmholtz Research Center Munich, Dr. rer. nat.

2004-2020?????????????????????????? group leader, scientific assistant, Institute of Cardiovascular Physiology and Pathophysiology, LMU, Munich

2016??????????????????????????????????? Habilitation in Physiology, LMU Munich

03/2020 – present?????????????? scientific assistant, Institute for Theoretical 伟德国际_伟德国际1946$娱乐app游戏icine, Physiology, 伟德国际_伟德国际1946$娱乐app游戏 of Augsburg

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