伟德国际_伟德国际1946$娱乐app游戏

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Prof. Dr. Jan Lipfert

Lehrstuhlinhaber
Experimentalphysik I
Telefon: +49 821 598 3300
E-Mail:
Raum: 340 (R)
Sprechzeiten: Anmeldung im Sekretariat
Adresse: Universit?tsstra?e 1 (Physik Nord), 86159 Augsburg

Lebenslauf

  • seit 2024? ? Professor (W3), Institut?für?Physik
    ? ? ? ? ? ? ? ? ? ?Universit?t?Augsburg
  • seit 2022? ? Professor ("hoogleraar"), Department of Physics
    ? ? ? ? ? ? ? ? ? ?Universit?t?Utrecht, Niederlande
  • 2018-2022??Prodekan, Fakult?t für Physik
    ? ? ? ? ? ? ? ? ? ?LMU München
  • 2013-2022??Professor (W2, tenured seit 2018), Fakult?t für Physik
    ?? ? ? ? ? ? ? ? ? ?
    LMU München
  • 2008-2013??Post doc and Veni fellow, Department of Bionanoscience
    ? ? ? ? ? ? ? ? ? ? TU Delft, Niederlande
  • 2002-2008??Ph.D. in Physik
    ? ? ? ? ? ? ? ? ? ? Stanford 伟德国际_伟德国际1946$娱乐app游戏, USA
  • 2001-2002??M.Sc. in Physik
    ?? ? ? ? ? ? ? ? ? 伟德国际_伟德国际1946$娱乐app游戏 of Illinois at Urbana-Champaign, IL, USA
  • 2000-2001??M.Phil. in Physik?und Mathematik
    ?? ? ? ? ? ? ? ? ?
    ?Universit?t?Uppsala, Schweden
  • 1998-2000??Vordiplom in Volkswirtschaftslehre
    ? ? ? ? ? ? ? ? ? ?
    Universit?t?Heidelberg
  • 1998-2000??Vordiplom in Physik
    ?? ? ? ? ? ? ? ? ??
    Universit?t?Heidelberg

Auszeichnungen und Preise

  • 2022???? Lehrpreis der Fakult?t für Biologie ("BioPlus"), LMU München
  • 2021???? Lehrpreis der Fakult?t für Chemie und Pharmazie?("Preis für gute Lehre"), LMU München
  • 2020???? ERC Consolidator Grant (Beginn:?2022)
  • 2020???? Lehrpreis der Fakult?t für Biologie ("BioPlus"), LMU München
  • 2019???? CeNS publication award in der Kategorie "scientific breakthrough"
  • 2019???? Lehrpreis der Fakult?t für Physik für die beste Bachelorvorlesung?("Goldener Sommerfeld"), LMU München
  • 2018???? Lehrpreis der Fakult?t für Chemie und Pharmazie?("Preis für gute Lehre"), LMU München
  • 2018???? F1000 section head "Methods in Biological Physics"
  • 2016???? Forschung@LMU Preis für studentische Forschung
  • 2016???? CeNS publication award in der Kategorie "scientific breakthrough"
  • 2010-2013 ? ??Veni fellowship der Netherlands Organisation for Scientific Research (NWO)
  • 2007???? Margaret C. Etter Student Lecturer Award der American Crystallographic Association
  • 2006???? Student travel award für das 2006 SAS meeting in Kyoto, Japan
  • 2001-2002 ? ??Fulbright Stipendium
  • 2001-2004 ? ??Stipendium der Studienstiftung des Deutschen Volkes

Forschungsschwerpunkte

We are fascinated by how?biological macromolecules (DNA, RNA, and proteins) adopt their three-dimensional shapes, make specific interactions, can deform under external forces and torques, and undergo conformational transitions to carry out the biological functions they have evolved to do. We use a range of biophysical tools, in particular single-molecule magnetic tweezers and solution X-ray scattering,?to provide insights into the structure and mechanisms of these biological machines.

Publikationen

2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004

2025

Samuel Stubhan, Anna V. Baptist, Caroline K?r?sy, Alessandra Narducci, Gustavo Gabriel Moya Mu?oz, Nicolas Wendler, Aidin Lak, Michael Sztucki, Thorben Cordes und Jan Lipfert
Determination of absolute intramolecular distances in proteins using anomalous X-ray scattering interferometry

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2024

Stefanie D. Pritzl, Alptu? Ulug?l, Caroline K?r?sy, Laura Filion und Jan Lipfert
Accurate drift-invariant single-molecule force calibration using the Hadamard variance

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Aidin Lak, Yihao Wang, Pauline J. Kolbeck, Christoph Pauer, Mohammad Suman Chowdhury, Marco Cassani, Frank Ludwig, Thilo Viereck, Florian Selbach, Philip Tinnefeld, Meinhard Schilling, Tim Liedl, Joe Tavacoli und Jan Lipfert
Cooperative dynamics of DNA-grafted magnetic nanoparticles optimize magnetic biosensing and coupling to DNA origami

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Samuel Stubhan, Anna V. Baptist, Caroline K?r?sy, Alessandra Narducci, Gustavo Gabriel Moya Mu?oz, Nicolas Wendler, Aidin Lak, Michael Sztucki, Thorben Cordes und Jan Lipfert
Determination of absolute intramolecular distances in proteins by anomalous X-ray scattering interferometry

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Yi-Yun Lin, Peter Müller, Evdoxia Karagianni, Nicola Hepp, Felix Mueller-Planitz, Willem Vanderlinden und Jan Lipfert
Epigenetic histone modifications H3K36me3 and H4K5/8/12/16ac induce open polynucleosome conformations via different mechanisms

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Marjolein de Jager, Pauline J. Kolbeck, Willem Vanderlinden, Jan Lipfert und Laura Filion
Exploring protein-mediated compaction of DNA by coarse-grained simulations and unsupervised learning

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Pauline J. Kolbeck, Marjolein de Jager, Margherita Gallano, Tine Brouns, Ben Bekaert, Wout Frederickx, Sebastian F. Konrad, Siska Van Belle, Frauke Christ, Steven De Feyter, Zeger Debyser, Laura Filion, Jan Lipfert und Willem Vanderlinden
HIV integrase compacts viral DNA into biphasic condensates

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Li-Ting Chen, Myrthe Jager, Dàmi Rebergen, Geertruid J. Brink, Tom van den Ende, Willem Vanderlinden, Pauline Kolbeck, Marc Pagès-Gallego, Ymke van der Pol, Nicolle Besselink, Norbert Moldovan, Nizar Hami, Wigard Kloosterman, Hanneke van Laarhoven, Florent Mouliere, Ronald Zweemer, Jan Lipfert, Sarah Derks, Alessio Marcozzi und Jeroen de Ridder
Nanopore-based consensus sequencing enables accurate multimodal tumor cell-free DNA profiling

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Magnus S. Bauer, Sophia Gruber, Adina Hausch, Marcelo C. R. Melo, Priscila S. F. C. Gomes, Thomas Nicolaus, Lukas F. Milles, Hermann E. Gaub, Rafael C. Bernardi und Jan Lipfert
Single-molecule force stability of the SARS-CoV-2–ACE2 interface in variants-of-concern

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Pauline J. Kolbeck, Milo? Ti?ma, Brian T. Analikwu, Willem Vanderlinden, Cees Dekker und Jan Lipfert
Supercoiling-dependent DNA binding: quantitative modeling and applications to bulk and single-molecule experiments

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Hana Dohnalová, Mona Seifert, Eva Matou?ková, Misha Klein, Flávia S. Papini, Jan Lipfert, David Dulin und Filip Lanka?
Temperature-dependent twist of double-stranded RNA probed by magnetic tweezer experiments and molecular dynamics simulations

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2023

Pauline J. Kolbeck, Mihir Dass, Irina V. Martynenko, Relinde J. A. van Dijk-Moes, Kelly J. H. Brouwer, Alfons van Blaaderen, Willem Vanderlinden, Tim Liedl und Jan Lipfert
DNA origami fiducial for accurate 3D atomic force microscopy imaging

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Yi-Yun Lin, Tine Brouns, Pauline J. Kolbeck, Willem Vanderlinden und Jan Lipfert
High-yield ligation-free assembly of DNA constructs with nucleosome positioning sequence repeats for single-molecule manipulation assays

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Christian Gebhardt, Pascal Bawidamann, Konstantin Schütze, Gabriel G. Moya Mu?oz, Anna-Katharina Spring, Douglas A. Griffith, Jan Lipfert und Thorben Cordes
Labelizer: systematic selection of protein residues for covalent fluorophore labeling

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Pauline J. Kolbeck, Dihia Benaoudia, Léa Chazot-Franguiadakis, Gwendoline Delecourt, Jér?me Mathé, Sha Li, Romeo Bonnet, Pascal Martin, Jan Lipfert, Anna Salvetti, Mordjane Boukhet, Véronique Bennevault, Jean-Christophe Lacroix, Philippe Guégan und Fabien Montel
Thermally switchable nanogate based on polymer phase transition

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2022

Sophia Gruber, Achim L?f, Adina Hausch, Fabian Kutzki, Res J?hr, Tobias Obser, Gesa K?nig, Reinhard Schneppenheim, Camilo Aponte-Santamaría, Frauke Gr?ter, Maria A. Brehm, Martin Benoit und Jan Lipfert
A conformational transition of the D'D3 domain primes von Willebrand factor for multimerization

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Magnus S. Bauer, Sophia Gruber, Adina Hausch, Priscila S. F. C. Gomes, Lukas F. Milles, Thomas Nicolaus, Leonard C. Schendel, Pilar López Navajas, Erik Procko, Daniel Lietha, Marcelo C. R. Melo, Rafael C. Bernardi, Hermann E. Gaub und Jan Lipfert
A tethered ligand assay to probe SARS-CoV-2:ACE2 interactions

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Willem Vanderlinden, Enrico Skoruppa, Pauline J. Kolbeck, Enrico Carlon und Jan Lipfert
DNA fluctuations reveal the size and dynamics of topological domains

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Sebastian F. Konrad, Willem Vanderlinden und Jan Lipfert
Quantifying epigenetic modulation of nucleosome breathing by high-throughput AFM imaging

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Sergio Cruz-León, Willem Vanderlinden, Peter Müller, Tobias Forster, Georgina Staudt, Yi-Yun Lin, Jan Lipfert und Nadine Schwierz
Twisting DNA by salt

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2021

Willem Vanderlinden und Jan Lipfert
A gentle twist on DNA

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Sebastian Konrad, Willem Vanderlinden und Jan Lipfert
A high-throughput pipeline to determine DNA and nucleosome conformations by AFM imaging

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Sebastian F. Konrad, Willem Vanderlinden, Wout Frederickx, Tine Brouns, Bj?rn H. Menze, Steven De Feyter und Jan Lipfert
High-throughput AFM analysis reveals unwrapping pathways of H3 and CENP-A nucleosomes

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Pauline J. Kolbeck, Willem Vanderlinden, Gerd Gemmecker, Christian Gebhardt, Martin Lehmann, Aidin Lak, Thomas Nicolaus, Thorben Cordes und Jan Lipfert
Molecular structure, DNA binding mode, photophysical properties and recommendations for use of SYBR Gold

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A correction has been published: Nucleic Acids Research, Volume 49, Issue 21, 2 December 2021, Pages 12601–12602, https://doi.org/10.1093/nar/gkab1164

Ann-Kathrin Reichenwallner, Esma Vurmaz, Kristina Battis, Laura Handl, Helin ?stün, Tivadar Mach, Gabriele H?rnig, Jan Lipfert und Lukas Richter
Optical investigation of individual red blood cells for determining cell count and cellular hemoglobin concentration in a microfluidic channel

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2020

Willem Vanderlinden, Pauline J. Kolbeck, Franziska Kriegel, Philipp U. Walker und Jan Lipfert
A benchmark data set for the mechanical properties of double-stranded DNA and RNA under torsional constraint

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Shan Zhao, Mihail Ivilinov Todorov, Ruiyao Cai, Rami Al-Maskari, Hanno Steinke, Elisabeth Kemter, Hongcheng Mai, Zhouyi Rong, Martin Warmer, Karen Stanic, Oliver Schoppe, Johannes Christian Paetzold, Benno Gesierich, Milagros N. Wong, Tobias B. Huber, Marco Duering, Oliver Thomas Bruns, Bjoern Menze, Jan Lipfert, Victor G. Puelles, Eckhard Wolf, Ingo Bechmann und Ali Ertürk
Cellular and molecular probing of intact human organs

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Hana Dohnalová, Tomá? Dr?ata, Ji?í ?poner, Martin Zacharias, Jan Lipfert und Filip Lanka?
Compensatory mechanisms in temperature dependence of DNA double helical structure: bending and elongation

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Sophia Gruber, Achim L?f, Steffen M. Sedlak, Martin Benoit, Hermann E. Gaub und Jan Lipfert
Designed anchoring geometries determine lifetimes of biotin–streptavidin bonds under constant load and enable ultra-stable coupling

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Katharina Ott, Linda Martini, Jan Lipfert und Ulrich Gerland
Dynamics of the buckling transition in double-stranded DNA and RNA

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Aidin Lak, Tamara Kahmann, Simon Jakob Schaper, Jaroslava Obel, Frank Ludwig, Peter Müller-Buschbaum und Jan Lipfert
The dissociation rate of acetylacetonate ligands governs the size of ferrimagnetic zinc ferrite nanocubes

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Willem Vanderlinden, Pauline J. Kolbeck, Tine Brouns, Zeger Debyser und Jan Lipfert
The free energy landscape of retroviral integration and molecular mechanisms of DNA compaction [Abstract]

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Sophia Gruber, Achim L?f, Tobias Obser, Maria A. Brehm, Martin Benoit und Jan Lipfert
The low-force response of Von Willebrand factor revealed by magnetic tweezers [Abstract]

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Thomas Zettl, Xuesong Shi, Steve Bonilla, Steffen M. Sedlak, Jan Lipfert und Daniel Herschlag
The structural ensemble of a Holliday junction determined by X-ray scattering interference

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2019

Abhijeet Pataskar, Willem Vanderlinden, Johannes Emmerig, Aditi Singh, Jan Lipfert und Vijay K. Tiwari
Deciphering the gene regulatory landscape encoded in DNA biophysical features

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Achim L?f, Philipp U. Walker, Steffen M. Sedlak, Sophia Gruber, Tobias Obser, Maria A. Brehm, Martin Benoit und Jan Lipfert
Multiplexed protein force spectroscopy reveals equilibrium protein folding dynamics and the low-force response of von Willebrand factor

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Willem Vanderlinden, Pauline J. Kolbeck, Wout Frederickx, Sebastian F. Konrad, Thomas Nicolaus, Carola Lampe, Alexander S. Urban, Cécile Moucheron und Jan Lipfert
Ru(TAP)32+ uses multivalent binding to accelerate and constrain photo-adduct formation on DNA

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Willem Vanderlinden, Tine Brouns, Philipp U. Walker, Pauline J. Kolbeck, Lukas F. Milles, Wolfgang Ott, Philipp C. Nickels, Zeger Debyser und Jan Lipfert
The free energy landscape of retroviral integration

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2018

Philipp U. Walker, Willem Vanderlinden und Jan Lipfert
Dynamics and energy landscape of DNA plectoneme nucleation

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Tine Brouns, Herlinde De Keersmaecker, Sebastian F. Konrad, Noriyuki Kodera, Toshio Ando, Jan Lipfert, Steven De Feyter und Willem Vanderlinden
Free energy landscape and dynamics of supercoiled DNA by high-speed atomic force microscopy

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Thomas Zettl, Rebecca S. Mathew, Xuesong Shi, Sebastian Doniach, Daniel Herschlag, Pehr A. B. Harbury und Jan Lipfert
Gold nanocrystal labels provide a sequence–to–3D structure map in SAXS reconstructions

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Franziska Kriegel, Willem Vanderlinden, Thomas Nicolaus, Angelika Kardinal und Jan Lipfert
Measuring single-molecule twist and torque in multiplexed magnetic tweezers

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Jan Lipfert
Parallelized magnetic torque tweezers probe DNA mechanics and viral integration [Abstract]

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Milo? T. Ivanovi?, Linda K. Bruetzel, Roman Shevchuk, Jan Lipfert und Jochen S. Hub
Quantifying the influence of the ion cloud on SAXS profiles of charged proteins

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Maarten M. van Oene, Seungkyu Ha, Tessa Jager, Mina Lee, Francesco Pedaci, Jan Lipfert und Nynke H. Dekker
Quantifying the precision of single-molecule torque and twist measurements using Allan variance

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Thomas Zettl, Rhiju Das, Pehr A. B. Harbury, Daniel Herschlag, Jan Lipfert, Rebecca S. Mathew und Xuesong Shi
Recording and analyzing nucleic acid distance distributions with X‐ray scattering interferometry (XSI)

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Nadine Harrer, Christina E. M. Schindler, Linda K. Bruetzel, Ignasi Forné, Johanna Ludwigsen, Axel Imhof, Martin Zacharias, Jan Lipfert und Felix Mueller-Planitz
Structural architecture of the nucleosome remodeler ISWI determined from cross-linking, mass spectrometry, SAXS, and modeling

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Milo? T. Ivanovi?, Linda K. Bruetzel, Jan Lipfert und Jochen S. Hub
Temperature‐dependent atomic models of detergent micelles refined against small‐angle X‐ray scattering data

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Franziska Kriegel, Christian Matek, Tomá? Dr?ata, Klara Kulenkampff, Sophie Tschirpke, Martin Zacharias, Filip Lanka? und Jan Lipfert
The temperature dependence of the helical twist of DNA

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Linda K. Bruetzel, Philipp U. Walker, Thomas Gerling, Hendrik Dietz und Jan Lipfert
Time-resolved small-angle X-ray scattering reveals millisecond transitions of a DNA origami switch

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2017

Maarten M. van Oene, Laura E. Dickinson, Bronwen Cross, Francesco Pedaci, Jan Lipfert und Nynke H. Dekker
Applying torque to the Escherichia coli flagellar motor using magnetic tweezers

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A Corrigendum to this article was published at: https://doi.org/10.1038/srep46980

Hayk Vardanyan, Simon Sindbert, Stanislav Kalinin, Christian A. Hanke, Tomasz Soltynski, Grzegorz Lach, Danilo Springstubbe, Bettina Apel, Edward Snell, Thomas D. Grant, Jan Lipfert, Sabine Müller, Janusz M. Bujnicki, Holger Gohlke und Claus A. M. Seidel
FRET, SAXS and molecular simulations resolve the solution structures of three coexisting conformers of flexible RNA four-way junction [Abstract]

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F. Kriegel und Jan Lipfert
Magnetic (torque) tweezers to probe mechanical properties of dsDNA [Abstract]

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L. K. Brützel, P. U. Walker, T. Gerling, H. Dietz und Jan Lipfert
Monitoring conformational states and kinetics of DNA origami objects by small-angle X-ray scattering [Abstract]

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P. U. Walker, A. L?f und Jan Lipfert
Probing the conformational dynamics of proteins with high multiplexed magnetic tweezers [Abstract]

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Franziska Kriegel, Niklas Ermann und Jan Lipfert
Probing the mechanical properties, conformational changes, and interactions of nucleic acids with magnetic tweezers

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Franziska Kriegel, Niklas Ermann, Ruaridh Forbes, David Dulin, Nynke H. Dekker und Jan Lipfert
Probing the salt dependence of the torsional stiffness of DNA by multiplexed magnetic torque tweezers

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Steffen M. Sedlak, Linda K. Bruetzel und Jan Lipfert
Quantitative evaluation of statistical errors in small-angle X-ray scattering measurements

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Sabrina Simoncelli, Samuel Johnson, Franziska Kriegel, Jan Lipfert und Jochen Feldmann
Stretching and heating single DNA molecules with optically trapped gold–silica Janus particles

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Stefanos K. Nomidis, Franziska Kriegel, Willem Vanderlinden, Jan Lipfert und Enrico Carlon
Twist-bend coupling and the torsional response of double-stranded DNA

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2016

Linda K. Bruetzel, Stefan Fischer, Annalena Salditt, Steffen M. Sedlak, Bert Nickel und Jan Lipfert
A Mo-anode-based in-house source for small-angle X-ray scattering measurements of biological macromolecules

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Thomas Zettl, Rebecca S. Mathew, S?nke Seifert, Sebastian Doniach, Pehr A. B. Harbury und Jan Lipfert
Absolute intramolecular distance measurements with angstrom-resolution using anomalous small-angle X-ray scattering

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Linda K. Bruetzel, Thomas Gerling, Steffen M. Sedlak, Philipp U. Walker, Wenjun Zheng, Hendrik Dietz und Jan Lipfert
Conformational changes and flexibility of DNA devices observed by small-angle X-ray scattering

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Christina E. M. Schindler, Nadine Harrer, Jan Lipfert, Felix Müller-Planitz und Martin Zacharias
Integrative modeling of the ISWI chromatin remodeling enzyme from cross-linking/mass spectrometry and Saxs data

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Jochen?P. Müller, Achim L?f, Salomé Mielke, Tobias Obser, Linda?K. Bruetzel, Willem Vanderlinden, Jan Lipfert, Reinhard Schneppenheim und Martin Benoit
pH-dependent interactions in dimers govern the mechanics and structure of von Willebrand factor

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2015

Maarten M. van Oene, Laura E. Dickinson, Francesco Pedaci, Mariana K?ber, David Dulin, Jan Lipfert und Nynke H. Dekker
Biological magnetometry: torque on superparamagnetic beads in magnetic fields

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Erratum: Phys. Rev. Lett. 120, 259901 (2018) DOI: https://doi.org/10.1103/PhysRevLett.114.218301

Magdalena Gebala, George M. Giamba?u, Jan Lipfert, Namita Bisaria, Steve Bonilla, Guangchao Li, Darrin M. York und Daniel Herschlag
Cation–anion interactions within the nucleic acid ion atmosphere revealed by ion counting

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Jan Lipfert und N. H. Dekker
De RNA helix lijkt niet altijd op die van DNA

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Korbinian Liebl, Tomas Drsata, Filip Lankas, Jan Lipfert und Martin Zacharias
Explaining the striking difference in twist-stretch coupling between DNA and RNA: a comparative molecular dynamics analysis

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David Dulin, Tao Ju Cui, Jelmer Cnossen, Margreet?W. Docter, Jan Lipfert und Nynke?H. Dekker
High spatiotemporal-resolution magnetic tweezers: calibration and applications for DNA dynamics

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Rifka Vlijm, Mina Lee, Jan Lipfert, Alexandra Lusser, Cees Dekker und Nynke?H. Dekker
Nucleosome assembly dynamics involve spontaneous fluctuations in the handedness of tetrasomes

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Jan Lipfert, Maarten M. van Oene, Mina Lee, Francesco Pedaci und Nynke H. Dekker
Torque spectroscopy for the study of rotary motion in biological systems

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2014

Z. Yu, D. Dulin, J. P. Cnossen, M. Kober, M. M. van Oene, O. Ordu, B. A. Berghuis, T. Hensgens, Jan Lipfert und N. H. Dekker
A force calibration standard for magnetic tweezers

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Zhongbo Yu, David Dulin, Jelmer Cnossen, Mariana K?ber, Maarten M. van Oene, Orkide Ordu, Bojk A. Berghuis, Toivo Hensgens, Jan Lipfert und Nynke H. Dekker
A force calibration standard for magnetic tweezers

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Fang-Chieh Chou, Jan Lipfert und Rhiju Das
Blind predictions of DNA and RNA tweezers experiments with force and torque

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Jan Lipfert, Gary M. Skinner, Johannes M. Keegstra, Toivo Hensgens, Tessa Jager, David Dulin, Mariana K?ber, Zhongbo Yu, Serge P. Donkers, Fang-Chieh Chou, Rhiju Das und Nynke H. Dekker
Double-stranded RNA under force and torque: similarities to and striking differences from double-stranded DNA

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Jan Lipfert, Mina Lee, Orkide Ordu, Jacob W. J. Kerssemakers und Nynke H. Dekker
Magnetic tweezers for the measurement of twist and torque

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Maarten van Oene, Laura E. Dickinson, Francesco Pedaci, Jan Lipfert, David Dulin, Jelmer P. Cnossen, Margreet W. Docter und Nynke H. Dekker
Magnetization properties of superparamagnetic beads [Abstract]

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Rifka Vlijm, Mina Lee, Jan Lipfert, Alexandra Lusser, Cees Dekker und Nynke H. Dekker
Nucleosome dynamics involve spontaneous fluctuations in the handedness of tetrasomes [Abstract]

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Jan Lipfert, Maarten van Oene, Tessa Jager, Mina Lee, Francesco Pedaci und Nynke H. Dekker
Quantifying the resolution of single-molecule torque measurements by Allan variance [Abstract]

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Willem Vanderlinden, Jan Lipfert, Jonas Demeulemeester, Zeger Debyser und Steven De Feyter
Structure, mechanics, and binding mode heterogeneity of LEDGF/p75–DNA nucleoprotein complexes revealed by scanning force microscopy

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Ryan C. Oliver, Jan Lipfert, Daniel A. Fox, Ryan H. Lo, Justin J. Kim, Sebastian Doniach und Linda Columbus
Tuning micelle dimensions and properties with binary surfactant mixtures

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Jan Lipfert, Sebastian Doniach, Rhiju Das und Daniel Herschlag
Understanding nucleic acid–ion interactions

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2013

Ryan C. Oliver, Jan Lipfert, Daniel A. Fox, Ryan H. Lo, Sebastian Doniach und Linda Columbus
Dependence of micelle size and shape on detergent alkyl chain length and head group

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Ryan C. Oliver, Jan Lipfert und Linda Columbus
Modulating the physical properties of micelles for membrane protein investigations [Abstract]

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Jan Lipfert, Gary M. Skinner, Johannes Keegstra, Toivo Hensgens, Tessa Jager, David Dulin, Serge Donkers und Nynke H. Dekker
Probing the response of double-stranded RNA to force and torque at the single-molecule level [Abstract]

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M. Lee, Jan Lipfert, H. Sanchez, C. Wyman und N. H. Dekker
Structural and torsional properties of the RAD51-dsDNA nucleoprotein filament

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David Dulin, Jan Lipfert, M. Charl Moolman und Nynke H. Dekker
Studying genomic processes at the single-molecule level: introducing the tools and applications

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2012

Xander J. A. Janssen, Jan Lipfert, Tessa Jager, Renier Daudey, Jaap Beekman und Nynke H. Dekker
Electromagnetic torque tweezers: a versatile approach for measurement of single-molecule twist and torque

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Xander J. A. Janssen, Jan Lipfert, C. F. Daudey, Jelle van der Does, Dimitri Roos, Jaap Beekman und Nynke H. Dekker
Introducing the electromagnetic torque tweezers [Abstract]

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Adelene Y. L. Sim, Jan Lipfert, Daniel Herschlag und Sebastian Doniach
Salt dependence of the radius of gyration and flexibility of single-stranded DNA in solution probed by small-angle x-ray scattering

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Adele Y. L. Sim, Jan Lipfert, Daniel Herschlag und Sebastian Doniach
Salt dependence of the radius of gyration and flexibility of single-stranded DNA in solution probed by small-angle x-ray scattering

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S. Doniach und Jan Lipfert
Small and wide angle X-ray scattering from biological macromolecules and their complexes in solution

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Jan Lipfert, Gary M. Skinner, Serge Donkers, Zhuangxiong Huang, David Dulin, Johannes M. Keegstra, Toivo Hensgens und Nynke H. Dekker
The mechanical properties of double-stranded RNA in response to force and torque [Abstract]

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2011

Jan Lipfert, Jacob J. W. Kerssemakers, Maylon Rojer und Nynke H. Dekker
A method to track rotational motion for use in single-molecule biophysics

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Gary M. Skinner, Serge P. Donkers, Jan Lipfert, Zhuangxiong Huang und Nynke H. Dekker
Characterization of supercoiled double-stranded RNA, and comparison to double-stranded DNA [Abstract]

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Jan Lipfert, Matthew Wiggin, Jacob W. J. Kerssemakers, Francesco Pedaci und Nynke H. Dekker
Freely orbiting magnetic tweezers to directly monitor changes in the twist of nucleic acids

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Correction published at DOI: 10.1038/ncomms8192

Matthew J. Wiggin, Jan Lipfert, Roeland van Wijk, Jakob Kerssemakers und Nynke Dekker
Freely orbiting magnetic tweezers: a new twist on single molecule force spectroscopy [Abstract]

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Jan Lipfert, Gary M. Skinner, Matthew J. Wiggin, Jacob W. K. Kerssemakers, Tessa Jager und Nynke H. Dekker
Magnetic torque tweezers and their application in probing the torsional properties of DNA, RNA, and DNA filaments [Abstract]

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Jan Lipfert, F. Pedaci, M. Wiggin, Z. Huang, J. W. J. Kerssemakers, G. M. Skinner, S. Barland, T. Jager, M. van Oene und N. H. Dekker
O-686 Single-molecule torque spectroscopy for biophysical investigations [Abstract]

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Published in: 8th EBSA European Biophysics Congress, August 23rd–27th 2011, Budapest, Hungary, Abstracts

Aartjan J. W. te Velthuis, Jacob W. J. Kerssemakers, Jan Lipfert und Nynke H. Dekker
Quantitative guidelines for force calibration through spectral analysis of magnetic tweezers data [Abstract]

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Jan Lipfert, Daniel Herschlag, Sebastian Doniach und Nynke H. Dekker
RNA structure, function, and (thermo-) dynamics: a SAXS and single-molecule perspective [Abstract]

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2010

S. Menze, C. Menze, Jan Lipfert, B. Menze und G. Harsch
Der Vorfahr aus der Bronzezeit

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Jan Lipfert, Adelene Y. L. Sim, Daniel Herschlag und Sebastian Doniach
Dissecting electrostatic screening, specific ion binding, and ligand binding in an energetic model for glycine riboswitch folding

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Jan Lipfert, Jacob W. J. Kerssemakers, Tessa Jager und Nynke H. Dekker
Magnetic torque tweezers: measuring torsional stiffness in DNA and RecA-DNA filaments

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Aartjan J. W. te Velthuis, Jacob W. J. Kerssemakers, Jan Lipfert und Nynke H. Dekker
Quantitative guidelines for force calibration through spectral analysis of?magnetic tweezers data

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Gary M. Skinner, Serge P. Donkers, Jan Lipfert und Nynke H. Dekker
Supercoiling double-stranded RNA [Abstract]

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Mona Ali, Jan Lipfert, Soenke Seifert, Daniel Herschlag und Sebastian Doniach
The ligand-free state of the TPP riboswitch: a partially folded RNA structure

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Jan Lipfert, Peter Jan Laverman, Iris Koster, Komaraiah Palle, Mary-Ann Bjornsti und Nynke H. Dekker
Topoisomerase IB activity investigated by single molecule magnetic tweezers: mechanisms of cytotoxicity [Abstract]

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Jan Lipfert, S. Klijnhout und N. H. Dekker
Torsional sensing of small-molecule binding using magnetic tweezers

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2009

Vincent B. Chu, Jan Lipfert, Yu Bai, Vijay S. Pande, Sebastian Doniach und Daniel Herschlag
Do conformational biases of simple helical junctions influence RNA folding stability and specificity?

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I. D. Vilfan, Jan Lipfert, D. A. Koster, S. G. Lemay und N. H. Dekker
Magnetic tweezers for single-molecule experiments

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Linda Columbus, Jan Lipfert, Kalyani Jambunathan, Daniel A. Fox, Adelene Y. L. Sim, Sebastian Doniach und Scott A. Lesley
Mixing and matching detergents for membrane protein NMR structure determination

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Linda Columbus, Jan Lipfert, Kalyani Jambunathan, Daniel A. Fox, Adelene Y. L. Sim, Sebastian Doniach und Scott A. Lesley
Mixing and matching detergents for membrane protein NMR structure determination [Abstract]

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Jan Lipfert, Xiaomin Hao und Nynke H. Dekker
Quantitative modeling and optimization of magnetic tweezers

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Jan Lipfert, Daniel Herschlag und Sebastian Doniach
Riboswitch conformations revealed by small-angle X-ray scattering

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Adelene Y. L. Sim, Jan Lipfert, Daniel Herschlag und Sebastian Doniach
Scaling behavior of single stranded DNA measured by small angle x-ray scattering [Abstract]

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Jan Lipfert, Daniel A. Koster, Igor D. Vilfan, Susanne Hage und Nynke H. Dekker
Single-molecule magnetic tweezers studies of type IB topoisomerases

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Jan Lipfert, Sven Klijnhout und Nynke H. Dekker
Small-molecule binding to DNA under tension and twist studied by magnetic tweezers [Abstract]

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Sebastian Doniach und Jan Lipfert
Use of small angle X-ray scattering (SAXS) to characterize conformational states of functional RNAs

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2008

Vincent B. Chu, Yu Bai, Jan Lipfert, Daniel Herschlag und Sebastian Doniach
A repulsive field: advances in the electrostatics of the ion atmosphere

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Yu Bai, Vincent B. Chu, Jan Lipfert, Vijay S. Pande, Daniel Herschlag und Sebastian Doniach
Critical assessment of nucleic acid electrostatics via experimental and computational investigation of an unfolded state ensemble

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Benjamin J. Spink, Sivaraj Sivaramakrishnan, Jan Lipfert, Sebastian Doniach und James A. Spudich
Long single α-helical tail domains bridge the gap between structure and function of myosin VI

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Jan Lipfert, Jonathan Ouellet, David G. Norman, Sebastian Doniach und David M. J. Lilley
The complete VS ribozyme in solution studied by small-angle x-ray scattering

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2007

Jan Lipfert
A tandem aptamer riboswitch from vibrio cholerae requires specific divalent ions for glycine binding [Poster abstract]

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Jan Lipfert, Linda Columbus, Vincent B. Chu und Sebastian Doniach
Analysis of small-angle X-ray scattering data of protein–detergent complexes by singular value decomposition

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Vincent B. Chu, Yu Bai, Jan Lipfert, Daniel Herschlag und Sebastian Doniach
Evaluation of ion binding to DNA duplexes using a size-modified Poisson-Boltzmann theory

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Jan Lipfert, Vincent B. Chu, Yu Bai, Daniel Herschlag und Sebastian Doniach
Low-resolution models for nucleic acids from small-angle X-ray scattering with applications to electrostatic modeling

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Jan Lipfert, Vincent B. Chu, Yu Bai, Jonathan Ouellet, David M. J. Lilley, Daniel Herschlag und Sebastian Doniach
Modeling RNA low resolution structure and thermodynamics from small-angle X-ray scattering [Abstract]

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Yu Bai, Max Greenfeld, Kevin J. Travers, Vincent B. Chu, Jan Lipfert, Sebastian Doniach und Daniel Herschlag
Quantitative and comprehensive decomposition of the ion atmosphere around nucleic acids

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Jan Lipfert, Linda Columbus, Vincent B. Chu, Scott A. Lesley und Sebastian Doniach
Size and shape of detergent micelles determined by small-angle X-ray scattering

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Jan Lipfert
Small-angle X-ray scattering of RNA, proteins, and membrane protein-detergent complexes

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Dissertation, Stanford 伟德国际_伟德国际1946$娱乐app游戏, 2007

Jan Lipfert und Sebastian Doniach
Small-angle x-ray scattering from RNA, proteins, and protein complexes

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Jan Lipfert, Rhiju Das, Vincent B. Chu, Madhuri Kudaravalli, Nathan Boyd, Daniel Herschlag und Sebastian Doniach
Structural transitions and thermodynamics of a glycine-dependent riboswitch from Vibrio cholerae

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Timothy J. Wilson, Jonathan Oullet, Jan Lipfert, Aileen McLeod und David M. J. Lilley
The structure and catalytic mechanism of the VS ribozyme [Abstract]

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2006

Linda Columbus, Jan Lipfert, Heath Klock, Ian Millett, Sebastian Doniach und Scott A. Lesley
Expression, purification, and characterization of Thermotoga maritima membrane proteins for structure determination

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Gautam Dantas, Alexander L. Watters, Bradley M. Lunde, Ziad M. Eletr, Nancy G. Isern, Toby Roseman, Jan Lipfert, Sebastian Doniach, Martin Tompa, Brian Kuhlman, Barry L. Stoddard, Gabriele Varani und David Baker
Mis-translation of a computationally designed protein yields an exceptionally stable homodimer: implications for protein engineering and evolution

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Jan Lipfert, Ian S. Millett, S?nke Seifert und Sebastian Doniach
Sample holder for small-angle x-ray scattering static and flow cell measurements

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2005

Jan Lipfert, Joel Franklin, Fang Wu und Sebastian Doniach
Protein misfolding and amyloid formation for the peptide GNNQQNY from yeast prion protein Sup35: simulation by reaction path annealing

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Bojan Zagrovic, Jan Lipfert, Eric J. Sorin, Ian S. Millett, Wilfred F. van Gunsteren, Sebastian Doniach und Vijay S. Pande
Unusual compactness of a polyproline type II structure

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Jan Lipfert und S. Donaich
Unzipping the polar zipper: molecular dynamics simulation of force induced beta-amyloid disassembly and implications for future experiments [Abstract]

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2004

Jan Lipfert, Jorge Llano und Leif A. Eriksson
Radiation-induced damage in serine phosphate - insights into a mechanism for direct DNA strand breakage

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