伟德国际_伟德国际1946$娱乐app游戏 cations are indispensable for RNA folding and function, two interlinked and vitally important physiological processes. State-of-the-art simulation techniques and consistent modeling allow us to provide a comprehensive view of cation-RNA interactions in systems ranging from basic structural motifs to large, biologically relevant, and catalytically active RNA macromolecules.

Resolving the molecular mechanism by which metal ion influence biomolecules is challenging. To solve this problem, we use smart sampling techniques such as transition path sampling and deep learning to recognize the relevant patterns and to make robust predictions.

伟德国际_伟德国际1946$娱乐app游戏 ions are essential in many vital processes. Our aim is to develop accurate, atomistic models that closely match a broad range of experimental properties including the interactions with biomolecules. This allows us to resolve the role of cations such as Magnesium in biological processes at the molecular level.

Using coarse-grained simulations, we have resolved the folding pathways of an RNA G-quadruplex. Our results provide detailed insights into the molecular steps and contribute to a deeper understanding of these important regulatory RNA structures.